Results 51 to 60 of about 101,358 (257)

Fabrication, Properties, and Applications of Scaffolds for Bone Tissue Regeneration

Advanced Materials Technologies, EarlyView.
This review explores cutting‐edge biomaterials and fabrication techniques for scaffolds in bone tissue regeneration. It conducts a critical comparison of various strategies, meticulously analyzes the key contradictions in the field, and outlines an integrated development path spanning from biomaterial selection to clinical application, while ...
Shangsi Chen, Min Wang
wiley   +1 more source

Insulin-like growth factor-1 reduces cardiac autosis through decreasing AMPK/FOXO1 signaling and Na+/K+-ATPase-Beclin-1 interaction

Archives of Medical Science
Introduction Insulin-like growth factor-1 (IGF-1) promotes survival and inhibits cardiac autophagy disruption. Methods Male Wistar rats were treated with IGF-1 (50 µg/kg), and 24 h after injection hearts were excised.
Katarina Banjac, MIlan Obradovic, Sonja Zafirovic, Esma R. Isenovic   +3 more
doaj   +1 more source

Inhibition of IGF-1R-Dependent PI3K Activation Sensitizes Colon Cancer Cells Specifically to DR5-Mediated Apoptosis But Not to rhTRAIL

Analytical Cellular Pathology, 2010
Background: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) initiates apoptosis in tumor cells upon binding to its cognate agonistic receptors, death receptors 4 and 5 (DR4 and DR5). The activity of the insulin-like growth factor 1 (IGF-1)
Bodvael Pennarun, Jan H. Kleibeuker, Tjitske Oenema, Janet H. Stegehuis, Elisabeth G.E. de Vries, Steven de Jong   +5 more
doaj   +1 more source

CRTC1/MAML2 directs a PGC-1α-IGF-1 circuit that confers vulnerability to PPARγ inhibition

Cell Reports, 2021
Summary: Mucoepidermoid carcinoma (MEC) is a life-threatening salivary gland cancer that is driven primarily by a transcriptional coactivator fusion composed of cyclic AMP-regulated transcriptional coactivator 1 (CRTC1) and mastermind-like 2 (MAML2). The
Adele M. Musicant, Kshitij Parag-Sharma, Weida Gong, Monideepa Sengupta, Arindam Chatterjee, Erin C. Henry, Yi-Hsuan Tsai, Michele C. Hayward, Siddharth Sheth, Renee Betancourt, Trevor G. Hackman, Ricardo J. Padilla, Joel S. Parker, Jimena Giudice, Colin A. Flaveny, David N. Hayes, Antonio L. Amelio   +16 more
doaj   +1 more source

Antidepressant-like effects of insulin and IGF-1 are mediated by IGF-1 receptors in the brain

Brain Research Bulletin, 2018
Depression is associated with uncontrolled diabetes, which indicates a lack of insulin effect, yet the role of the insulin receptor in mediating depression is not clearly established because insulin receptors are not required for glucose entry into the brain.
Paul L. Mueller, Carolyn E. Pritchett, Tyler N. Wiechman, Alevtina Zharikov, Andras Hajnal   +4 more
openaire   +2 more sources

TSH/IGF-1 Receptor Cross Talk in Graves' Ophthalmopathy Pathogenesis [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2016
Abstract Context: The TSH receptor (TSHR) is considered the main target of stimulatory autoantibodies in the pathogenesis of Graves' ophthalmopathy (GO); however, it has been suggested that stimulatory IGF-1 receptor (IGF-1R) autoantibodies also play a role.
Christine C, Krieger, Robert F, Place, Carmine, Bevilacqua, Bernice, Marcus-Samuels, Brent S, Abel, Monica C, Skarulis, George J, Kahaly, Susanne, Neumann, Marvin C, Gershengorn   +8 more
openaire   +2 more sources

The Osteoblastic Microenvironment Determines the Fate of Breast Cancer Cells Disseminated in the Bone Marrow

Advanced Science, EarlyView.
This study revealed how the osteoblastic microenvironment determines the fate of cancer cells disseminated in bone, with a focus on whether they colonize, reside in quiescence, or reactivate from dormancy. Targeting integrin signaling may offer promising strategies for preventing quiescent cancer cells reactivation and bone colonization.
Hong‐Li Wang, Rui Zhang, Xiao‐Min Yue, Jie Zhou, Yu‐Fan Huang, Rong Meng, Yu‐Li Wang, Xiao‐Qing Li   +7 more
wiley   +1 more source

Insulin signaling is critical for sinoatrial node maintenance and function

Experimental and Molecular Medicine, 2023
Insulin and insulin-like growth factor 1 (IGF-1) signaling regulate cellular growth and glucose metabolism in the myocardium. However, their physiological role in the cells of the cardiac conduction system has never been explored. Therefore, we sought to
Sangmi Ock, Seong Woo Choi, Seung Hee Choi, Hyun Kang, Sung Joon Kim, Wang-Soo Lee, Jaetaek Kim   +6 more
doaj   +1 more source

The effect of acromegaly on thyroid disease

Endocrine Journal, 2023
Long-term stimulation of thyroid follicular epithelium by high growth hormone (GH) and insulin-like growth factor-1 (IGF-1) in patients with acromegaly can lead to thyroid dysfunction, goiter, thyroid nodules, and even thyroid cancer and thyroid ...
Caiyan Mo, Liyong Zhong
doaj   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source