Results 31 to 40 of about 17,525 (157)

Insulin-like growth factor receptor signaling in breast tumor epithelium protects cells from endoplasmic reticulum stress and regulates the tumor microenvironment

Breast Cancer Research, 2018
Background Early analyses of human breast cancer identified high expression of the insulin-like growth factor type 1 receptor (IGF-1R) correlated with hormone receptor positive breast cancer and associated with a favorable prognosis, whereas low ...
Alison E. Obr, Sushil Kumar, Yun-Juan Chang, Joseph J. Bulatowicz, Betsy J. Barnes, Raymond B. Birge, Deborah A. Lazzarino, Emily Gallagher, Derek LeRoith, Teresa L. Wood   +9 more
doaj   +1 more source

R1507, an anti-insulin-like growth factor-1 receptor (IGF-1R) antibody, and EWS/FLI-1 siRNA in Ewing's sarcoma: convergence at the IGF/IGFR/Akt axis. [PDF]

PLoS ONE, 2011
A subset of patients with Ewing's sarcoma responds to anti-insulin-like growth factor-1 receptor (IGF-1R) antibodies. Mechanisms of sensitivity and resistance are unknown. We investigated whether an anti-IGF-1R antibody acts via a pathway that could also
Helen J Huang, Laura S Angelo, Jordi Rodon, Michael Sun, Klaus-Peter Kuenkele, Henrique A Parsons, Jonathan C Trent, Razelle Kurzrock   +7 more
doaj   +1 more source

Disorders of IGFs and IGF-1R signaling pathways

Molecular and Cellular Endocrinology, 2020
The insulin-like growth factor (IGF) system comprises two ligands, IGF-I and IGF-II, that regulate multiple physiological processes, including mammalian development, metabolism and growth, through the type 1 IGF receptor (IGF-1R). The growth hormone (GH)-IGF-I axis is the major regulator of longitudinal growth.
Forbes, B.E., Blyth, A.J., Wit, J.M.
openaire   +3 more sources

Upregulation of IGF-1R expression during neoadjuvant therapy predicts poor outcome in breast cancer patients. [PDF]

PLoS ONE, 2015
The insulin-like growth factor 1 receptor (IGF-1R) may be involved in the development of resistance against conventional cancer treatment. The aim of this study was to assess whether IGF-1R expression of breast tumors changes during neoadjuvant therapy ...
Sandra Heskamp, Otto C Boerman, Janneke D M Molkenboer-Kuenen, Carla A Wauters, Luc J A Strobbe, Caroline M P W Mandigers, Peter Bult, Wim J G Oyen, Winette T A van der Graaf, Hanneke W M van Laarhoven   +9 more
doaj   +1 more source

A kinase-independent biological activity for insulin growth factor-1 receptor (IGF-1R): Implications for Inhibition of the IGF-1R signal [PDF]

Oncotarget, 2013
It has been demonstrated that epidermal growth factor receptor (EGFR) can have kinase independent activity. EGFR kinase-independent function maintains intracellular glucose levels via sodium glucose transporter protein 1 (SGLT1) and supports cell survival. It is plausible that this phenomenon can apply to other receptor tyrosine kinases.
Janku, Filip, Huang, Helen J, Angelo, Laura S, Kurzrock, Razelle   +3 more
openaire   +4 more sources

Effective natural inhibitors targeting IGF-1R by computational study

Aging, 2022
IGF-1R belongs to a tyrosine kinase family and is currently a newly discovered drug target. IGF-1R inhibitors can bind directly to IGF-1R to achieve the effect of inhibiting the function of IGF-1R. At present, IGF-1R inhibitors have good clinical effects on Ewing sarcoma in the clinic. In this article, we screened compounds capable of inhibiting IGF-1R
Wang, Xinyu, Zhou, Pengcheng, Lin, Liangxin, Wu, Bo, Fu, Zhaoyu, Huang, Xing, Zhu, Dong   +6 more
openaire   +2 more sources

Direct Selection of Functional De Novo Macrocycles for Activation of On‐Cellulo Insulin Receptor

Angewandte Chemie, EarlyView.
A live‐cell screening platform, RaPID‐ExCells, integrates mRNA display‐derived macrocyclic peptide libraries with functional selection against native cell‐surface receptors. Application to the insulin receptor enabled de novo discovery of a macrocyclic agonist that activates endogenous signaling despite weak in vitro binding, highlighting the power of ...
Yun‐Hsuan Kuo, Emiko Mihara, Junichi Takagi, Hiroaki Suga   +3 more
wiley   +2 more sources

IGF-1R Inhibition Activates a YES/SFK Bypass Resistance Pathway: Rational Basis for Co-Targeting IGF-1R and Yes/SFK Kinase in Rhabdomyosarcoma

Neoplasia: An International Journal for Oncology Research, 2015
The insulin-like growth factor 1 receptor (IGF-1R) has surfaced as a significant target in multiple solid cancers due to its fundamental roles in pro-survival and anti-apoptotic signaling.
Xiaolin Wan, Choh Yeung, Christine Heske, Arnulfo Mendoza, Lee J. Helman   +4 more
doaj   +1 more source

IGF-1R down regulates the sensitivity of hepatocellular carcinoma to sorafenib through the PI3K / akt and RAS / raf / ERK signaling pathways

BMC Cancer, 2023
Background Insulin-like growth factor-1 receptor (IGF-1R) promotes cell proliferation and migration and inhibitsapoptosis, all of which can contribute to the development of cancers.
Wenpeng Cai, Yongfang Ma, Li Song, Niandie Cao, Jiafeng Gao, Shuping Zhou, Xiaolong Tang   +6 more
doaj   +1 more source

High expression levels of total IGF-1R and sensitivity of NSCLC cells in vitro to an anti-IGF-1R antibody (R1507). [PDF]

PLoS ONE, 2009
The IGF receptor type 1 (IGF-1R) pathway is frequently deregulated in human tumors and has become a target of interest for anti-cancer therapy.We used a panel of 22 non-small cell lung cancer (NSCLC) cell lines to investigate predictive biomarkers of ...
Yixuan Gong, Evelyn Yao, Ronglai Shen, Aviva Goel, Maria Arcila, Julie Teruya-Feldstein, Maureen F Zakowski, Stanley Frankel, Martin Peifer, Roman K Thomas, Marc Ladanyi, William Pao   +11 more
doaj   +1 more source