Results 31 to 40 of about 19,264 (196)

Deficiency in type 1 insulin-like growth factor receptor in mice protects against oxygen-induced lung injury

Respiratory Research, 2005
Background Cellular responses to aging and oxidative stress are regulated by type 1 insulin-like growth factor receptor (IGF-1R). Oxidant injury, which is implicated in the pathophysiology of a number of respiratory diseases, acutely upregulates IGF-1R ...
Flejou Jean-François, Bonora Monique, Holzenberger Martin, Epaud Ralph, Ahamed Karmene, Puard Julien, Clement Annick, Henrion-Caude Alexandra   +7 more
doaj   +1 more source

The Role of IGF-1R in Pediatric Malignancies [PDF]

The Oncologist, 2009
Learning Objectives Evaluate the components that make up the insulin-like growth factor family. Differentiate between different strategies to modulate IGF-1R. Determine when to utilize the rationale for therapeutic targeting of IGF-1R in childhood malignancies.
Su Young, Kim, Jeffrey A, Toretsky, Daniel, Scher, Lee J, Helman   +3 more
openaire   +2 more sources

GIGYF1 disruption associates with autism and impaired IGF-1R signaling. [PDF]

J Clin Invest, 2022
Autism spectrum disorder (ASD) represents a group of neurodevelopmental phenotypes with a strong genetic component. An excess of likely gene-disruptive (LGD) mutations in GIGYF1 was implicated in ASD. Here, we report that GIGYF1 is the second-most mutated gene among known ASD high-confidence risk genes.
Chen G, Yu B, Tan S, Tan J, Jia X, Zhang Q, Zhang X, Jiang Q, Hua Y, Han Y, Luo S, Hoekzema K, Bernier RA, Earl RK, Kurtz-Nelson EC, Idleburg MJ, Madan-Khetarpal S, Clark R, Sebastian J, Fernandez-Jaen A, Alvarez S, King SD, Ramos LL, Santos MLS, Martin DM, Brooks D, Symonds JD, Cutcutache I, Pan Q, Hu Z, Yuan L, Eichler EE, Xia K, Guo H.   +33 more
europepmc   +4 more sources

R1507, an anti-insulin-like growth factor-1 receptor (IGF-1R) antibody, and EWS/FLI-1 siRNA in Ewing's sarcoma: convergence at the IGF/IGFR/Akt axis. [PDF]

PLoS ONE, 2011
A subset of patients with Ewing's sarcoma responds to anti-insulin-like growth factor-1 receptor (IGF-1R) antibodies. Mechanisms of sensitivity and resistance are unknown. We investigated whether an anti-IGF-1R antibody acts via a pathway that could also
Helen J Huang, Laura S Angelo, Jordi Rodon, Michael Sun, Klaus-Peter Kuenkele, Henrique A Parsons, Jonathan C Trent, Razelle Kurzrock   +7 more
doaj   +1 more source

Insulin-like growth factor receptor signaling in breast tumor epithelium protects cells from endoplasmic reticulum stress and regulates the tumor microenvironment

Breast Cancer Research, 2018
Background Early analyses of human breast cancer identified high expression of the insulin-like growth factor type 1 receptor (IGF-1R) correlated with hormone receptor positive breast cancer and associated with a favorable prognosis, whereas low ...
Alison E. Obr, Sushil Kumar, Yun-Juan Chang, Joseph J. Bulatowicz, Betsy J. Barnes, Raymond B. Birge, Deborah A. Lazzarino, Emily Gallagher, Derek LeRoith, Teresa L. Wood   +9 more
doaj   +1 more source

Upregulation of IGF-1R expression during neoadjuvant therapy predicts poor outcome in breast cancer patients. [PDF]

PLoS ONE, 2015
The insulin-like growth factor 1 receptor (IGF-1R) may be involved in the development of resistance against conventional cancer treatment. The aim of this study was to assess whether IGF-1R expression of breast tumors changes during neoadjuvant therapy ...
Sandra Heskamp, Otto C Boerman, Janneke D M Molkenboer-Kuenen, Carla A Wauters, Luc J A Strobbe, Caroline M P W Mandigers, Peter Bult, Wim J G Oyen, Winette T A van der Graaf, Hanneke W M van Laarhoven   +9 more
doaj   +1 more source

Effective natural inhibitors targeting IGF-1R by computational study

Aging, 2022
IGF-1R belongs to a tyrosine kinase family and is currently a newly discovered drug target. IGF-1R inhibitors can bind directly to IGF-1R to achieve the effect of inhibiting the function of IGF-1R. At present, IGF-1R inhibitors have good clinical effects on Ewing sarcoma in the clinic. In this article, we screened compounds capable of inhibiting IGF-1R
Wang, Xinyu, Zhou, Pengcheng, Lin, Liangxin, Wu, Bo, Fu, Zhaoyu, Huang, Xing, Zhu, Dong   +6 more
openaire   +2 more sources

IGF-1R down regulates the sensitivity of hepatocellular carcinoma to sorafenib through the PI3K / akt and RAS / raf / ERK signaling pathways

BMC Cancer, 2023
Background Insulin-like growth factor-1 receptor (IGF-1R) promotes cell proliferation and migration and inhibitsapoptosis, all of which can contribute to the development of cancers.
Wenpeng Cai, Yongfang Ma, Li Song, Niandie Cao, Jiafeng Gao, Shuping Zhou, Xiaolong Tang   +6 more
doaj   +1 more source

High expression levels of total IGF-1R and sensitivity of NSCLC cells in vitro to an anti-IGF-1R antibody (R1507). [PDF]

PLoS ONE, 2009
The IGF receptor type 1 (IGF-1R) pathway is frequently deregulated in human tumors and has become a target of interest for anti-cancer therapy.We used a panel of 22 non-small cell lung cancer (NSCLC) cell lines to investigate predictive biomarkers of ...
Yixuan Gong, Evelyn Yao, Ronglai Shen, Aviva Goel, Maria Arcila, Julie Teruya-Feldstein, Maureen F Zakowski, Stanley Frankel, Martin Peifer, Roman K Thomas, Marc Ladanyi, William Pao   +11 more
doaj   +1 more source

IGF-1R Inhibition Activates a YES/SFK Bypass Resistance Pathway: Rational Basis for Co-Targeting IGF-1R and Yes/SFK Kinase in Rhabdomyosarcoma

Neoplasia: An International Journal for Oncology Research, 2015
The insulin-like growth factor 1 receptor (IGF-1R) has surfaced as a significant target in multiple solid cancers due to its fundamental roles in pro-survival and anti-apoptotic signaling.
Xiaolin Wan, Choh Yeung, Christine Heske, Arnulfo Mendoza, Lee J. Helman   +4 more
doaj   +1 more source