Global and Conditional Disruption of the Igf-I Gene in Osteoblasts and/or Chondrocytes Unveils Epiphyseal and Metaphyseal Bone-Specific Effects of IGF-I in Bone [PDF]
Biology, 2023 To evaluate the relative importance of IGF-I expression in various cell types for endochondral ossification, we quantified the trabecular bone at the secondary spongiosa and epiphysis of the distal femur in 8–12-week-old male mice with a global knockout ...
Weirong Xing +3 more
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New modulators for IGF-I activity within IGF-I processing products [PDF]
Frontiers in Endocrinology, 2013 Insulin-like growth factor I (IGF-I) is a key regulator of muscle development and growth. The pre-pro-peptide produced by the Igf1 gene undergoes several post-translational processing steps to result in a secreted mature protein, which is thought to be ...
Becky Kathleen Brisson +1 more
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Brain IGF-I regulates LTP, spatial memory, and sexual dimorphic behavior [PDF]
Life Science Alliance, 2023 A lack of brain-synthesized IGF-I almost completely abrogates hippocampal long-term potentiation (LTP), alters spatial memory and sex-dependent behavior, and produces major changes in the mouse hippocampal proteome.
Raquel Herrero-Labrador +12 more
doaj +2 more sources
IGF-I concentration determines cell fate by converting signaling dynamics as a bifurcation parameter in L6 myoblasts [PDF]
Scientific ReportsInsulin-like growth factor (IGF)-I mediates long-term activities that determine cell fate, including cell proliferation and differentiation. This study aimed to characterize the mechanisms by which IGF-I determines cell fate from the aspect of IGF-I ...
Ryosuke Okino +10 more
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Muscle insulin-like growth factor-I modulates murine craniofacial bone growth [PDF]
European Cells & Materials, 2021 Insulin-like growth factor I (IGF-I) is essential for muscle and bone development and a primary mediator of growth hormone (GH) actions. While studies have elucidated the importance of IGF-I specifically in muscle or bone development, few studies to date
HJ Kok +5 more
doaj +1 more source
Deficiency of liver-derived insulin-like growth factor-I (IGF-I) does not interfere with the skin wound healing rate. [PDF]
PLoS ONE, 2018 IGF-I is a growth factor, which is expressed in virtually all tissues. The circulating IGF-I is however derived mainly from the liver. IGF-I promotes wound healing and its levels are decreased in wounds with low regenerative potential such as diabetic ...
Ileana Ruxandra Botusan +12 more
doaj +1 more source
Molecular Therapy: Nucleic Acids, 2023 Insulin-like growth factor I (IGF-I) is a growth-promoting anabolic hormone that fosters cell growth and tissue homeostasis. IGF-I deficiency is associated with several diseases, including growth disorders and neurological and musculoskeletal diseases ...
Justin S. Antony +13 more
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Reduced Insulin-Like Growth Factor-I Effects in the Basal Forebrain of Aging Mouse
Frontiers in Aging Neuroscience, 2021 It is known that aging is frequently accompanied by a decline in cognition. Furthermore, aging is associated with lower serum IGF-I levels that may contribute to this deterioration.
Jonathan A. Zegarra-Valdivia +13 more
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Biomedicines, 2020 Physical activity (PA) and insulin-like growth factor I (IGF-I) have beneficial effects for patients who have suffered an ischemic stroke (stroke). However, the relationship between the levels of PA and IGF-I after stroke has not been explored in detail.
N. David Åberg +10 more
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Interaction between IGF-IR and ER induced by E2 and IGF-I. [PDF]
PLoS ONE, 2013 Estrogen receptor (ER) is a nuclear receptor and the insulin-like growth factor-I (IGF-I) receptor (IGF-IR) is a transmembrane tyrosine kinase receptor.
Zhenghong Yu +8 more
doaj +1 more source