Results 1 to 10 of about 103,912 (196)

Global and Conditional Disruption of the Igf-I Gene in Osteoblasts and/or Chondrocytes Unveils Epiphyseal and Metaphyseal Bone-Specific Effects of IGF-I in Bone [PDF]

Biology, 2023
To evaluate the relative importance of IGF-I expression in various cell types for endochondral ossification, we quantified the trabecular bone at the secondary spongiosa and epiphysis of the distal femur in 8–12-week-old male mice with a global knockout ...
Weirong Xing, Chandrasekhar Kesavan, Sheila Pourteymoor, Subburaman Mohan   +3 more
doaj   +2 more sources

New modulators for IGF-I activity within IGF-I processing products [PDF]

Frontiers in Endocrinology, 2013
Insulin-like growth factor I (IGF-I) is a key regulator of muscle development and growth. The pre-pro-peptide produced by the Igf1 gene undergoes several post-translational processing steps to result in a secreted mature protein, which is thought to be ...
Becky Kathleen Brisson, Elisabeth R Barton   +1 more
doaj   +4 more sources

IGF-I concentration determines cell fate by converting signaling dynamics as a bifurcation parameter in L6 myoblasts [PDF]

Scientific Reports
Insulin-like growth factor (IGF)-I mediates long-term activities that determine cell fate, including cell proliferation and differentiation. This study aimed to characterize the mechanisms by which IGF-I determines cell fate from the aspect of IGF-I ...
Ryosuke Okino, Kazuaki Mukai, Shunpei Oguri, Masato Masuda, Satoshi Watanabe, Yosuke Yoneyama, Sumine Nagaosa, Takafumi Miyamoto, Atsushi Mochizuki, Shin-Ichiro Takahashi, Fumihiko Hakuno   +10 more
doaj   +2 more sources

Muscle insulin-like growth factor-I modulates murine craniofacial bone growth [PDF]

European Cells & Materials, 2021
Insulin-like growth factor I (IGF-I) is essential for muscle and bone development and a primary mediator of growth hormone (GH) actions. While studies have elucidated the importance of IGF-I specifically in muscle or bone development, few studies to date
HJ Kok, CN Crowder, L Koo Min Chee, HY Choi, N Lin, ER Barton   +5 more
doaj   +1 more source

Deficiency of liver-derived insulin-like growth factor-I (IGF-I) does not interfere with the skin wound healing rate. [PDF]

PLoS ONE, 2018
IGF-I is a growth factor, which is expressed in virtually all tissues. The circulating IGF-I is however derived mainly from the liver. IGF-I promotes wound healing and its levels are decreased in wounds with low regenerative potential such as diabetic ...
Ileana Ruxandra Botusan, Xiaowei Zheng, Sampath Narayanan, Jacob Grünler, Vivekananda Gupta Sunkari, Freja S Calissendorff, Ishrath Ansurudeen, Christopher Illies, Johan Svensson, John-Olov Jansson, Claes Ohlsson, Kerstin Brismar, Sergiu-Bogdan Catrina   +12 more
doaj   +1 more source

IGF-I binding proteins, IGF-I binding protein mRNA and IGF-I receptor mRNA in rats with acute renal failure given IGF-I [PDF]

Kidney International, 1998
Recombinant human insulin-like growth factor-I (rhIGF-I) accelerates recovery from acute renal failure (ARF) in rats. IGF-I acts through the IGF-I receptor (IGF-IR) and its actions may be modified by IGF-I binding proteins (IGFBPs). It therefore would be of value to determine the effects of both ARF and rhIGF-I treatment on serum IGFBPs and mRNA for ...
Julien BohÉ, Kyungwoo Yoon, Kyungwoo Yoon, Raimund Hirschberg, Raimund Hirschberg, Joel D. Kopple, Joel D. Kopple, Hu Ding, Hu Ding, David P. Qing, David P. Qing, Grushenka H.I. Wolfgang, Grushenka H.I. Wolfgang   +12 more
openaire   +3 more sources

Indices of insulin-like growth factors family in the lung tissue of patients with non-small cell lung cancer after COVID-19 of various severity

Южно-Российский онкологический журнал, 2023
Purpose of the study. An analysis of levels of IGF and their carrying proteins in lung tissues of cancer patients depending on the severity of the previous COVID-19 infection.Patients and methods.
O. I. Kit, E. M. Frantsiyants, D. A. Kharagezov, V. A. Bandovkina, N. D. Cheryarina, Yu. A. Pogorelova, Yu. N. Lazutin, A. G. Milakin, I. A. Leyman, O. N/ Stateshny   +9 more
doaj   +1 more source

Membrane-associated insulin-like growth factor (IGF) binding structures in placental cells [PDF]

Journal of the Serbian Chemical Society, 2003
The biological activities of IGF-I and –II are mediated mainly by the type 1 IGF receptor (IGF 1R) and controlled by their interaction with soluble proteins, the IGF binding proteins (IGFBPs). Although there is a growing body of evidence that some IGFBPs
Masnikosa Romana M., Nikolić-Judith Anna, Nedić Olgica R.   +2 more
doaj   +1 more source

Interaction between IGF-IR and ER induced by E2 and IGF-I. [PDF]

PLoS ONE, 2013
Estrogen receptor (ER) is a nuclear receptor and the insulin-like growth factor-I (IGF-I) receptor (IGF-IR) is a transmembrane tyrosine kinase receptor.
Zhenghong Yu, Weimin Gao, Enze Jiang, Fang Lu, Luo Zhang, Zhaorong Shi, Xinxing Wang, Longbang Chen, Tangfeng Lv   +8 more
doaj   +1 more source

Evidence for the possible biological significance of the igf-1 gene alternative splicing in prostate cancer

Frontiers in Endocrinology, 2013
Insulin-like growth factor I (IGF-I) has been implicated in the pathogenesis of prostate cancer (PCa), since it plays a key role in cell proliferation, differentiation and apoptosis. The IGF-I actions are mediated mainly via its binding to the type I IGF
Anastassios ePhilippou, Athanasios eArmakolas, Michael ekoutsilieris   +2 more
doaj   +1 more source