Results 1 to 10 of about 14,093,235 (401)

New modulators for IGF-I activity within IGF-I processing products [PDF]

Frontiers in Endocrinology, 2013
Insulin-like growth factor I (IGF-I) is a key regulator of muscle development and growth. The pre-pro-peptide produced by the Igf1 gene undergoes several post-translational processing steps to result in a secreted mature protein, which is thought to be ...
Becky Kathleen Brisson, Elisabeth R Barton   +1 more
doaj   +4 more sources

Global and Conditional Disruption of the Igf-I Gene in Osteoblasts and/or Chondrocytes Unveils Epiphyseal and Metaphyseal Bone-Specific Effects of IGF-I in Bone [PDF]

Biology, 2023
To evaluate the relative importance of IGF-I expression in various cell types for endochondral ossification, we quantified the trabecular bone at the secondary spongiosa and epiphysis of the distal femur in 8–12-week-old male mice with a global knockout ...
Weirong Xing, Chandrasekhar Kesavan, Sheila Pourteymoor, Subburaman Mohan   +3 more
doaj   +2 more sources

IGF-I: A Key Growth Factor that Regulates Neurogenesis and Synaptogenesis from Embryonic to Adult Stages of the Brain

Frontiers in Neuroscience, 2016
The generation of neurons in the adult mammalian brain requires the activation of quiescent neural stem cells (NSCs). This activation and the sequential steps of neuron formation from NSCs are regulated by a number of stimuli, which include growth ...
Vanesa Nieto-Estévez, Çağla Defterali, Carlos Vicario-Abejón   +2 more
exaly   +2 more sources

Liver-spleen axis, insulin-like growth factor-(IGF)-I axis and fat mass in overweight/obese females [PDF]

Journal of Translational Medicine, 2011
Background Fat mass (FM) in overweight/obese subjects has a primary role in determining low-grade chronic inflammation and, in turn, insulin resistance (IR) and ectopic lipid storage within the liver.
Lombardi Gaetano, Orio Francesco, Rossi Annalisa, Nedi Valeria, De Rosa Annalba, Di Somma Carolina, Pizza Genoveffa, Savastano Silvia, Colao Annamaria, Tarantino Giovanni   +9 more
doaj   +2 more sources

Reference Values for IGF-I Serum Concentrations: Comparison of Six Immunoassays

Journal of Clinical Endocrinology and Metabolism, 2016
Context: Measurement of IGF-I is essential for diagnosis and management of patients with disorders affecting the somatotropic axis. However, even when IGF-I kit manufacturers follow recent consensus guidelines, different kits can give very different ...
Philippe Chanson, Armelle Arnoux-Guenegou, Jacques Young   +2 more
exaly   +2 more sources

IGF-I induces senescence of hepatic stellate cells and limits fibrosis in a p53-dependent manner

Scientific Reports, 2016
Hepatic fibrosis in nonalcoholic steatohepatitis (NASH) and cirrhosis determines patient prognosis; however, effective treatment for fibrosis has not been established.
Hidenori Fukuoka, Kentaro Suda, Hironori Bando   +2 more
exaly   +2 more sources

IGF-I concentration determines cell fate by converting signaling dynamics as a bifurcation parameter in L6 myoblasts [PDF]

Scientific Reports
Insulin-like growth factor (IGF)-I mediates long-term activities that determine cell fate, including cell proliferation and differentiation. This study aimed to characterize the mechanisms by which IGF-I determines cell fate from the aspect of IGF-I ...
Ryosuke Okino, Kazuaki Mukai, Shunpei Oguri, Masato Masuda, Satoshi Watanabe, Yosuke Yoneyama, Sumine Nagaosa, Takafumi Miyamoto, Atsushi Mochizuki, Shin-Ichiro Takahashi, Fumihiko Hakuno   +10 more
doaj   +2 more sources

Differences in the Distribution of IGF-I Concentrations Between European and US Populations. [PDF]

J Endocr Soc, 2022
Bidlingmaier M, Valcour A, Schilbach K, Kuehnle T, Diederich S, Rogge T, Cavalier E, Katayev A.   +7 more
europepmc   +3 more sources

Reference Intervals for Insulin-like Growth Factor-1 (IGF-I) From Birth to Senescence: Results From a Multicenter Study Using a New Automated Chemiluminescence IGF-I Immunoassay Conforming to Recent International Recommendations

Journal of Clinical Endocrinology and Metabolism, 2014
Martin Bidlingmaier, Rebecca T Emeny, Antje Körner   +2 more
exaly   +2 more sources

Muscle insulin-like growth factor-I modulates murine craniofacial bone growth [PDF]

European Cells & Materials, 2021
Insulin-like growth factor I (IGF-I) is essential for muscle and bone development and a primary mediator of growth hormone (GH) actions. While studies have elucidated the importance of IGF-I specifically in muscle or bone development, few studies to date
HJ Kok, CN Crowder, L Koo Min Chee, HY Choi, N Lin, ER Barton   +5 more
doaj   +1 more source