Results 111 to 120 of about 14,093,235 (401)

IGF-I and IGFBP-3 levels and their correlations with carcinoembryonic antigen in colorectal cancer patients

Alexandria Journal of Medicine, 2018
Background: Colorectal cancer is one of the most frequently seen cancers worldwide. Currently, CEA is the most commonly used tumor marker in colorectal cancer. The changes in IGF/IGFBP equilibrium is also known to cause carcinogenesis.
Çiğdem Yağcıoğlu Yücel, Gönül Erden, Fatma Meriç Yılmaz, Sevilay Sezer, Esin Çalcı   +4 more
doaj   +1 more source

Effect of insulin-like growth factor I on HIV type 1 long terminal repeat-driven chloramphenicol acetyltransferase expression

, 1999
In this study, we have investigated the ability of insulin-like growth factor I (IGF-I) to inhibit HIV long terminal repeat (LTR)-driven gene expression.
Adachi Y, Jorgensen JO, Laurence J, Lee MH, Newstein M, Peeters A, Spandidos DA, Wang LM, White MF, Zeichner SL, Zeichner SL   +10 more
core   +1 more source

Inhibition of insulin- and insulin-like growth factor-I-stimulated growth of human breast cancer cells by 1,25-dihydroxyvitamin D3 and the vitamin D3 analogue EB1089 [PDF]

, 1996
1, 25 Dihydroxyvitamin D3 (1,25-(OH)2D3) and a number of synthetic vitamin D3 analogues with low calcaemic activity, have been shown to inhibit breast cancer cell growth in vitro as well as in vivo.
Birkenhäger, J.C. (Jan), Buurman, C.J. (Cok), Leeuwen, J.P.T.M. (Hans) van, Pols, H.A.P. (Huib), Vink-Van Wijngaarden, T. (Trudy)   +4 more
core   +2 more sources

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

Growth hormone/insulin-like growth factor I axis in health and disease states: an update on the role of intra-portal insulin

Frontiers in Endocrinology
Growth hormone (GH) is the key regulator of insulin-like growth factor I (IGF-I) generation in healthy states. However, portal insulin delivery is also an essential co-player in the regulation of the GH/IGF-I axis by affecting and regulating hepatic GH ...
Kevin C. J. Yuen, Rikke Hjortebjerg, Rikke Hjortebjerg, Rikke Hjortebjerg, Ashok Ainkaran Ganeshalingam, Ashok Ainkaran Ganeshalingam, Ashok Ainkaran Ganeshalingam, David R. Clemmons, Jan Frystyk, Jan Frystyk   +9 more
doaj   +1 more source

Distinct organ-specific up- and down-regulation of IGF-I and IGF-II mRNA in various organs of a GH-overexpressing transgenic Nile tilapia [PDF]

, 2018
Several lines of GH-overexpressing fish have been produced and characterized concerning organ integrity, growth, fertility and health but few and contradictory data are available on IGF-I that mediates most effects of GH. Furthermore, nothing is known on
Berishvili, Giorgi, Caelers, Antje, Eppler, Elisabeth, Hwang, Gyulin, Maclean, Norman, Mazel, Peter, Reinecke, Manfred   +6 more
core  

Role of insulin-like growth factor binding protein-3 in 1, 25-dihydroxyvitamin-d 3 -induced breast cancer cell apoptosis. [PDF]

, 2013
Insulin-like growth factor I (IGF-I) is implicated in breast cancer development and 1, 25-dihydroxyvitamin D3 (1, 25-D3) has been shown to attenuate prosurvival effects of IGF-I on breast cancer cells.
Brosseau, C, Colston, KW, Pirianov, G
core   +2 more sources

“Time Is Brain” – for Cell Therapies

Advanced Science, EarlyView.
The concept that “time is brain” extends to stem cell therapy for stroke. Evidence across preclinical and clinical studies indicates that delivery timing shapes graft survival, integration, and efficacy by matching the evolving post‐stroke microenvironment.
Hao Yin, Dominikus Brian, Rebecca Z. Weber, Patrick D. Lyden, Ruslan Rust   +4 more
wiley   +1 more source

Heritability and Correlation Estimates for Serum Insulin-like Growth Factor I Concentration, Weight, Weight Gain, and Height in Angus Beef Cattle in a Long-Term Divergent Selection Study for Serum Insulin-like Growth Factor I (1989 to 2017)

Animals
This study investigated the genetic parameters for serum IGF-I concentrations and growth traits in beef cattle. A divergent selection experiment for serum IGF-I concentration was initiated in 1989. One hundred spring-calving (50 high line and 50 low line)
Michael E. Davis, Rosalia C. M. Simmen
doaj   +1 more source

DA Negatively Regulates IGF-I Actions Implicated in Cognitive Function via Interaction of PSD95 and nNOS in Minimal Hepatic Encephalopathy

Frontiers in Cellular Neuroscience, 2017
Insulin-like growth factor I (IGF-I) has been positively correlated with cognitive ability. Cognitive decline in minimal hepatic encephalopathy (MHE) was shown to be induced by elevated intracranial dopamine (DA). The beneficial effect of IGF-I signaling
Saidan Ding, Weishan Zhuge, Xuebao Wang, Jianjing Yang, Yuanshao Lin, Chengde Wang, Jiangnan Hu, Qichuan Zhuge   +7 more
doaj   +1 more source