Results 11 to 20 of about 14,093,235 (401)

Deficiency of liver-derived insulin-like growth factor-I (IGF-I) does not interfere with the skin wound healing rate. [PDF]

PLoS ONE, 2018
IGF-I is a growth factor, which is expressed in virtually all tissues. The circulating IGF-I is however derived mainly from the liver. IGF-I promotes wound healing and its levels are decreased in wounds with low regenerative potential such as diabetic ...
Ileana Ruxandra Botusan, Xiaowei Zheng, Sampath Narayanan, Jacob Grünler, Vivekananda Gupta Sunkari, Freja S Calissendorff, Ishrath Ansurudeen, Christopher Illies, Johan Svensson, John-Olov Jansson, Claes Ohlsson, Kerstin Brismar, Sergiu-Bogdan Catrina   +12 more
doaj   +1 more source

Local application of engineered insulin-like growth factor I mRNA demonstrates regenerative therapeutic potential in vivo

Molecular Therapy: Nucleic Acids, 2023
Insulin-like growth factor I (IGF-I) is a growth-promoting anabolic hormone that fosters cell growth and tissue homeostasis. IGF-I deficiency is associated with several diseases, including growth disorders and neurological and musculoskeletal diseases ...
Justin S. Antony, Pascale Birrer, Claudia Bohnert, Sina Zimmerli, Petra Hillmann, Hervé Schaffhauser, Christine Hoeflich, Andreas Hoeflich, Ramzi Khairallah, Andreas T. Satoh, Isabelle Kappeler, Isabel Ferreira, Klaas P. Zuideveld, Friedrich Metzger   +13 more
doaj   +1 more source

Reduced Insulin-Like Growth Factor-I Effects in the Basal Forebrain of Aging Mouse

Frontiers in Aging Neuroscience, 2021
It is known that aging is frequently accompanied by a decline in cognition. Furthermore, aging is associated with lower serum IGF-I levels that may contribute to this deterioration.
Jonathan A. Zegarra-Valdivia, Jonathan A. Zegarra-Valdivia, Jonathan A. Zegarra-Valdivia, Jonathan A. Zegarra-Valdivia, Irene Chaves-Coira, Maria Estrella Fernandez de Sevilla, Maria Estrella Fernandez de Sevilla, Laura Martinez-Rachadell, Laura Martinez-Rachadell, Julio Esparza, Ignacio Torres-Aleman, Ignacio Torres-Aleman, Ignacio Torres-Aleman, Angel Nuñez   +13 more
doaj   +1 more source

Relationship between Levels of Pre-Stroke Physical Activity and Post-Stroke Serum Insulin-Like Growth Factor I

Biomedicines, 2020
Physical activity (PA) and insulin-like growth factor I (IGF-I) have beneficial effects for patients who have suffered an ischemic stroke (stroke). However, the relationship between the levels of PA and IGF-I after stroke has not been explored in detail.
N. David Åberg, Gustaf Gadd, Daniel Åberg, Peter Hällgren, Christian Blomstrand, Katarina Jood, Michael Nilsson, Fredrick R. Walker, Johan Svensson, Christina Jern, Jörgen Isgaard   +10 more
doaj   +1 more source

Interaction between IGF-IR and ER induced by E2 and IGF-I. [PDF]

PLoS ONE, 2013
Estrogen receptor (ER) is a nuclear receptor and the insulin-like growth factor-I (IGF-I) receptor (IGF-IR) is a transmembrane tyrosine kinase receptor.
Zhenghong Yu, Weimin Gao, Enze Jiang, Fang Lu, Luo Zhang, Zhaorong Shi, Xinxing Wang, Longbang Chen, Tangfeng Lv   +8 more
doaj   +1 more source

IGF-I binding proteins, IGF-I binding protein mRNA and IGF-I receptor mRNA in rats with acute renal failure given IGF-I [PDF]

Kidney International, 1998
Recombinant human insulin-like growth factor-I (rhIGF-I) accelerates recovery from acute renal failure (ARF) in rats. IGF-I acts through the IGF-I receptor (IGF-IR) and its actions may be modified by IGF-I binding proteins (IGFBPs). It therefore would be of value to determine the effects of both ARF and rhIGF-I treatment on serum IGFBPs and mRNA for ...
BohÉ, Julien, Ding, Hu, Qing, David P., Yoon, Kyungwoo, Hirschberg, Raimund, Wolfgang, Grushenka H.I., Kopple, Joel D.   +6 more
openaire   +2 more sources

Liver-derived IGF-I regulates mean life span in mice. [PDF]

PLoS ONE, 2011
BACKGROUND: Transgenic mice with low levels of global insulin-like growth factor-I (IGF-I) throughout their life span, including pre- and postnatal development, have increased longevity.
Johan Svensson, Klara Sjögren, Jenny Fäldt, Niklas Andersson, Olle Isaksson, John-Olov Jansson, Claes Ohlsson   +6 more
doaj   +1 more source

IGF-I influences everolimus activity in medullary thyroid carcinoma [PDF]

, 2015
Context: Medullary thyroid carcinoma (MTC) is a rare tumor originating from thyroid parafollicular C cells. It has been previously demonstrated that insulin-like growth factor I (IGF-I) protects MTC from the effects of antiproliferative drugs. Everolimus,
degli Uberti, Ettore C., Di Pasquale, Carmelina, Gagliano, Teresa, GENTILIN, ERICA, MERANTE BOSCHIN, ISABELLA, Pelizzo, Mariarosa, Rossi, Martina, Rossi, Roberta, Tagliati, Federico, Zatelli, Maria Chiara   +9 more
core   +1 more source

Evidence for the possible biological significance of the igf-1 gene alternative splicing in prostate cancer

Frontiers in Endocrinology, 2013
Insulin-like growth factor I (IGF-I) has been implicated in the pathogenesis of prostate cancer (PCa), since it plays a key role in cell proliferation, differentiation and apoptosis. The IGF-I actions are mediated mainly via its binding to the type I IGF
Anastassios ePhilippou, Athanasios eArmakolas, Michael ekoutsilieris   +2 more
doaj   +1 more source

Insulin-Like Growth Factor II (IGF-II) Is More Potent Than IGF-I in Stimulating Cortisol Secretion from Cultured Bovine Adrenocortical Cells: Interaction with the IGF-I Receptor and IGF-Binding Proteins [PDF]

, 1995
Although the stimulating effect of insulin-like growth factor I (IGF-I) on adrenal steroidogenesis has been well established, the role of IGF-II in the adult adrenal gland remains unknown.
Engelhardt, Dieter, Fottner, Christian, Simmler, Pia, Weber, Matthias M.   +3 more
core   +1 more source