Results 51 to 60 of about 14,093,235 (401)

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

PEGylated insulin-like growth factor-I affords protection and facilitates recovery of lost functions post-focal ischemia

Scientific Reports, 2017
Insulin-like growth factor-I (IGF-I) is involved in the maturation and maintenance of neurons, and impaired IGF-I signaling has been shown to play a role in various neurological diseases including stroke.
Kim Parker, Antonio Berretta, Stefanie Saenger, Manaswini Sivaramakrishnan, Simon A. Shirley, Friedrich Metzger, Andrew N. Clarkson   +6 more
doaj   +1 more source

Do IGF-I concentrations better reflect growth hormone (GH) action in children with short stature than the results of GH stimulating tests? Evidence from the simultaneous assessment of thyroid function

Thyroid Research, 2011
Background The diagnosis of growth hormone (GH) deficiency (GHD) in short children seems unquestionable when both GH peak in stimulating tests (GHST) and IGF-I concentration are decreased.
Smyczyńska Joanna, Stawerska Renata, Lewiński Andrzej, Hilczer Maciej   +3 more
doaj   +1 more source

The Association Between IGF-I and Insulin Resistance

Diabetes Care, 2012
OBJECTIVE IGF-I has an almost 50% amino acid sequence homology with insulin and elicits nearly the same hypoglycemic response. Studies showed that low and high IGF-I levels are related to impaired glucose tolerance and to a higher risk of type 2 diabetes.
N. Friedrich, B. Thuesen, T. Jørgensen, A. Juul, C. Spielhagen, Henri Wallaschofksi, A. Linneberg   +6 more
semanticscholar   +1 more source

Kidney growth in normal and diabetic mice is not affected by human insulin-like growth factor binding protein-1 administration [PDF]

, 2005
Insulin-like growth factor I (IGF-I) accumulates in the kidney following the onset of diabetes, initiating diabetic renal hypertrophy. Increased renal IGF-I protein content, which is not reflected in messenger RNA (mRNA) levels ...
Cingel-Ristic, V., Drop, S.L.S. (Stenvert), Flyvbjerg, A. (Allan), Han, V.K., Rasch, R., Schrijvers, B.F., Vliet, A.K. (Arlène) van   +6 more
core   +2 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Human conditions of insulin-like growth factor-I (IGF-I) deficiency

Journal of Translational Medicine, 2012
Insulin-like growth factor I (IGF-I) is a polypeptide hormone produced mainly by the liver in response to the endocrine GH stimulus, but it is also secreted by multiple tissues for autocrine/paracrine purposes. IGF-I is partly responsible for systemic GH
J. Puche, I. Castilla-Cortázar
semanticscholar   +1 more source

Insulin-Like Growth Factor-I and Epidermal Growth Factor Regulate Insulin-Like Growth Factor Binding Protein-3 (IGFBP-3) in the Human Keratinocyte Cell Line HaCaT [PDF]

, 1995
The human keratinocyte cell line HaCaT has a basal phenotype and secretes an insulin-like growth factor (IGF) binding protein, IGFBP-3, which modulates its IGF-I response.
Werther, George A., Wraight, Christopher J.   +1 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Insulin-like Growth Factor-I Reduces Collagen Production by Hepatic Stellate Cells Through Stimulation of Collagen Degradation System via mTOR-Dependent Signaling Pathway

Biomedicines
Aim: The liver is the major source of circulating insulin-like growth factor (IGF)-I. Serum IGF-I levels are decreased in cirrhotic patients depending on severity.
Takako Nishikawa, Natsuko Ohtomo, Yukiko Inoue, Mami Takahashi, Hitoshi Ikeda, Kazuhiko Koike, Nobutake Yamamichi, Mitsuhiro Fujishiro, Tomoaki Tomiya   +8 more
doaj   +1 more source