Plasma Distribution and Signaling Activities of IGF-II Precursors
Endocrinology, 2011 IGF-II is thought to function through activation of the IGF-I receptor (IGF-IR) and the A isoform of the IR, with the IGF-IR being relevant to tumorigenesis and the IR to both tumorigenesis and metabolic control. In the paraneoplastic syndrome of nonislet cell tumor hypoglycemia, tumor-derived IGF-II has been proposed to exert both proliferative and ...
Alicia G, Marks +3 more
openaire +3 more sources
Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy [PDF]
, 2009 Mammalian target of rapamycin (mTOR) is a key regulator of cell growth that associates with raptor and rictor to form the mTOR complex 1 (mTORC1) and mTORC2, respectively.
Baas, Dominique +27 more
core +5 more sources
Radioimmunoassay for Insulin-Like Growth Factor II(IGF-II).
Endocrinologia Japonica, 1990 Insulin-like growth factor II (IGF-II) levels in human plasma were measured in physiological and pathological conditions by radioimmunoassay (RIA) with biosynthetic IGF-II. This RIA was specific for IGF-II and cross-reactivity with IGF-I was 1%. The sensitivity was 15 pg/tube with 50% displacement at 50 pg/tube.
K, Asakawa +6 more
openaire +3 more sources
Estrogen receptor-beta is a potential target for triple negative breast cancer treatment. [PDF]
, 2018 Triple Negative breast cancer (TNBC) is a subtype of breast cancer that lacks the expression of estrogen receptor (ER), progesterone receptor, and human epidermal growth factor receptor 2.
Austin, David +5 more
core +1 more source
Refractory hypoglycemia induced by a duodenal wall gastrointestinal stromal tumor: A case report
Caspian Journal of Internal Medicine, 2021 Background: Tumor-associated hypoglycemia can be caused by non-islet cell tumors including gastrointestinal stromal tumor (GIST) which is a rare paraneoplastic syndrome that leads to the release of insulin-like growth factor-2 (IGF-2). Case Presentation:
Foolad Eghbali, Reza Karami
doaj
The Role of SOX9 in IGF-II-Mediated Pulmonary Fibrosis. [PDF]
Int J Mol Sci, 2023 Waldrep KM +4 more
europepmc +1 more source
Expression of Insulinlike Growth Factor (IGF) and IGF-Binding Protein Genes in Human Lung Tumor Cell Lines [PDF]
, 2017 Background: The presence of multiple, low-molecular-weight, insulinlike growth factor (IGF)-binding proteins in lung tumor cell-conditioned medium and lung cancer patient serum has been recently reported.
Bleehen, N. M. +5 more
core
A daganatos és stroma sejtek közötti interakciók vizsgálata a gyomorrák kialakulásában és progressziójában. Klinikai és kísérletes vizsgálatok. = The role of tumor-stroma interactions in the initiation and progression of gastric cancer. Clinical and experimental studies. [PDF]
, 2013 Kísérleteink azt mutatták, hogy a humán gyomor miofibroblaszt sejtek (HGM) száma a rákos szövetben nagy mértékben megnövekedett, továbbá morfológiai és szerkezeti károsodást szenvedtek a normál szöveti sejtekhez képest.
Czepán, Mátyás +12 more
core
Dysglycemia With Impaired Insulin Secretion After Resection of a High-Molecular-Weight IGF-II-Producing Tumor. [PDF]
JCEM Case Rep, 2023 Shimada Y +3 more
europepmc +1 more source
RAB family gene expression in breast cancer cells under influence of paclitaxel [PDF]
, 2011 The aim of this study was to investigate the role of paclitaxel on RAB family of genes in primary breast cancer cell lines. The cancer breast cells obtained from 40 women during mastectomy were used to address this issue. The group included patients with
Andrzej Wilkolaski +3 more
core +1 more source