Results 11 to 20 of about 150,785 (321)

Early 5‐HT6 receptor blockade prevents symptom onset in a model of adolescent cannabis abuse

EMBO Molecular Medicine, 2020
Cannabis abuse during adolescence confers an increased risk for developing later in life cognitive deficits reminiscent of those observed in schizophrenia, suggesting common pathological mechanisms that remain poorly characterized.
Coralie Berthoux, Al Mahdy Hamieh, Angelina Rogliardo, Emilie L Doucet, Camille Coudert, Fabrice Ango, Katarzyna Grychowska, Séverine Chaumont‐Dubel, Pawel Zajdel, Rafael Maldonado, Joël Bockaert, Philippe Marin, Carine Bécamel   +12 more
doaj   +1 more source

Hif-1α and IGF Expression in Endometrial Hyperplasia

Journal of Education, Health and Sport, 2020
The objective: to assess the effect of insulin resistance and hypoxia on the risk of endometrial hyperplasia development. The research was conducted on the base of Municipal Maternity House №5 (Odessa, Ukraine).
Z. V. Chumak, M. V. Shapoval, O. G. Andrievskiy   +2 more
doaj   +1 more source

Cell Type-Specific mRNA Dysregulation in Hippocampal CA1 Pyramidal Neurons of the Fragile X Syndrome Mouse Model

Frontiers in Molecular Neuroscience, 2017
Fragile X syndrome (FXS) is a genetic disorder due to the silencing of the Fmr1 gene, causing intellectual disability, seizures, hyperactivity, and social anxiety. All these symptoms result from the loss of expression of the RNA binding protein fragile X
Laura Ceolin, Nathalie Bouquier, Jihane Vitre-Boubaker, Stéphanie Rialle, Dany Severac, Emmanuel Valjent, Julie Perroy, Emma Puighermanal   +7 more
doaj   +1 more source

Advances in the pathogenesis of Rett syndrome using cell models

Animal Models and Experimental Medicine, Volume 5, Issue 6, Page 532-541, December 2022., 2022
Most Rett syndrome (RTT) patients are affected by the MECP2 gene mutations. And the mutations of MECP2 have wide effects on different cell types of nervous system, including neurons, astrocytes, oligodendrocytes and microglia, which always combined together to lead to abnormalities in the whole neural network.
Sijia Lu, Yongchang Chen, Zhengbo Wang
wiley   +1 more source

PPARβ/δ priming enhances the anti-apoptotic and therapeutic properties of mesenchymal stromal cells in myocardial ischemia–reperfusion injury

Stem Cell Research & Therapy, 2022
Background Mesenchymal Stromal Cells (MSC) have been widely used for their therapeutic properties in many clinical applications including myocardial infarction.
Charlotte Sarre, Rafael Contreras-Lopez, Nitirut Nernpermpisooth, Christian Barrere, Sarah Bahraoui, Claudia Terraza, Gautier Tejedor, Anne Vincent, Patricia Luz-Crawford, Kantapich Kongpol, Sarawut Kumphune, Christophe Piot, Joel Nargeot, Christian Jorgensen, Farida Djouad, Stéphanie Barrere-Lemaire   +15 more
doaj   +1 more source

Systematic review of antitumour efficacy and mechanism of metformin activity in prostate cancer models

BJUI Compass, Volume 4, Issue 1, Page 44-58, January 2023., 2023
Abstract Metformin, the first line pharmacotherapy for type 2 diabetes has demonstrated favourable effects in prostate cancer (PCa) across a range of studies evaluating PCa patient outcomes amongst metformin users. However, a lack of rigorously conducted prospective studies has stalled clinical use in this setting.
Nan Fang Wang, Toni Rose Jue, Jeff Holst, Jennifer H. Gunter   +3 more
wiley   +1 more source

Functioning of the dimeric GABA(B) receptor extracellular domain revealed by glycan wedge scanning [PDF]

The EMBO Journal 27, 9 (2008) 1321-1332, 2008
The G-protein-coupled receptor (GPCR) activated by the neurotransmitter GABA is made up of two subunits, GABA(B1) and GABA(B2). GABA(B1) binds agonists, whereas GABA(B2) is required for trafficking GABA(B1) to the cell surface, increasing agonist affinity to GABA(B1), and activating associated G proteins.
arxiv   +1 more source

Molecular determinants involved in the allosteric control of agonist affinity in the GABAB receptor by the GABAB2 subunit [PDF]

The Journal of Biological Chemistry 279, 16 (2004) 15824-30, 2008
The gamma-aminobutyric acid type B (GABAB) receptor is an allosteric complex made of two subunits, GABAB1 (GB1) and GABAB2 (GB2). Both subunits are composed of an extracellular Venus flytrap domain (VFT) and a heptahelical domain (HD). GB1 binds GABA, and GB2 plays a major role in G-protein activation as well as in the high agonist affinity state of ...
arxiv   +1 more source

Comparison of mechanistic and hybrid modeling approaches for characterization of a CHO cultivation process: Requirements, pitfalls and solution paths

Biotechnology Journal, Volume 18, Issue 1, January 2023., 2023
Graphical Abstract and Lay Summary Successful bioprocess modeling starts with experimental planning and accordingly can fail at this early stage. Based on an antibody‐producing CHO fed‐batch process, requirements and pitfalls were investigated, exemplifying their impact on model performance and process characterization.
Benjamin Bayer, Mark Duerkop, Ralf Pörtner, Johannes Möller   +3 more
wiley   +1 more source

The IGF axis and hepatocarcinogenesis

Molecular Pathology, 2001
Deregulation of the insulin-like growth factor (IGF) axis, including the autocrine production of IGFs, IGF binding proteins (IGFBPs), IGFBP proteases, and the expression of the IGF receptors, has been identified in the development of hepatocellular carcinoma (HCC).
Scharf, Jens-Gerd, Dombrowski, F., Ramadori, Giuliano   +2 more
openaire   +5 more sources