Results 11 to 20 of about 151,710 (240)

FTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell

Nature Communications, 2021
The demethylase FTO was shown to remove on N6-methyladenosine (m6A) and N6, 2’-O-dimethyladenosine (m6Am) modifications on RNAs. Here the authors show that FTO impedes cancer stem cell-like abilities in colorectal cancer cells through its m6Am ...
Sébastien Relier, Julie Ripoll, Hélène Guillorit, Amandine Amalric, Cyrinne Achour, Florence Boissière, Jérôme Vialaret, Aurore Attina, Françoise Debart, Armelle Choquet, Françoise Macari, Virginie Marchand, Yuri Motorin, Emmanuelle Samalin, Jean-Jacques Vasseur, Julie Pannequin, Francesca Aguilo, Evelyne Lopez-Crapez, Christophe Hirtz, Eric Rivals, Amandine Bastide, Alexandre David   +21 more
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Insulin-like growth factors and their carrier proteins in kidneys of rats with experimental diabetes, malignant tumor, and their combination

Бюллетень сибирской медицины, 2022
Persistent hyperglycemia resulting from diabetes mellitus causes microvascular lesions and long-term diabetic complications, such as nephropathy.The aim of the study was to analyze the levels of insulin-like growth factors (IGFs), their carrier proteins (
E. M. Frantsiyants, V. A. Bandovkina, I. V. Kaplieva, E. I. Surikova, I. V. Neskubina, Yu. A. Pogorelova, L. K. Trepitaki, N. D. Cheryarina, I. M. Kotieva, M. I. Morozova   +9 more
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The mGlu7 receptor provides protective effects against epileptogenesis and epileptic seizures

Neurobiology of Disease, 2019
Finding new targets to control or reduce seizure activity is essential to improve the management of epileptic patients. We hypothesized that activation of the pre-synaptic and inhibitory metabotropic glutamate receptor type 7 (mGlu7) reduces spontaneous ...
Benoit Girard, Pola Tuduri, Maria Paula Moreno, Sophie Sakkaki, Cedric Barboux, Tristan Bouschet, Annie Varrault, Jihane Vitre, Isabelle McCort-Tranchepain, Julien Dairou, Francine Acher, Laurent Fagni, Nicola Marchi, Julie Perroy, Federica Bertaso   +14 more
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Disorders of IGFs and IGF-1R signaling pathways

Molecular and Cellular Endocrinology, 2020
The insulin-like growth factor (IGF) system comprises two ligands, IGF-I and IGF-II, that regulate multiple physiological processes, including mammalian development, metabolism and growth, through the type 1 IGF receptor (IGF-1R). The growth hormone (GH)-IGF-I axis is the major regulator of longitudinal growth.
Forbes, B.E., Blyth, A.J., Wit, J.M.
openaire   +3 more sources

The effect of powder peppermint on GH and IGF gene expression and hematology in Caspian roach (Rutilus caspicus) [PDF]

بوم‌شناسی آبزیان, 2019
In recent years, the administration of medicinal herbs as growth and innate immune stimulator has been increasing in fish. In this study, the effect of peppermint powder on GH and IGF gene expression and hematology was studied In Caspian roach (Rutilus ...
Hamed Paknejad, Abdolmajid Hajimoradloo, Soheila Rastgari, Marjan Hosseini, Hamed Azadi   +4 more
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GLP-1 and GIP receptors signal through distinct β-arrestin 2-dependent pathways to regulate pancreatic β cell function

Cell Reports, 2023
Summary: Glucagon-like peptide 1 (GLP-1R) and glucose-dependent insulinotropic polypeptide (GIPR) receptors are G-protein-coupled receptors involved in glucose homeostasis. Diabetogenic conditions decrease β-arrestin 2 (ARRB2) levels in human islets.
Nour Zaïmia, Joelle Obeid, Annie Varrault, Julia Sabatier, Christophe Broca, Patrick Gilon, Safia Costes, Gyslaine Bertrand, Magalie A. Ravier   +8 more
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Activation of different growth factor systems in tissues of adenocarcinoma and signet-ring cell carcinoma of the stomach

Исследования и практика в медицине, 2019
Purpose of the study. The purpose of the study was to find the difference between local levels of VEGF, EGF, IGFI and IG- FII in tumor and intact tissues in adenocarcinoma of the stomach (AC) and signet-ring cell carcinoma of the stomach (SRCC).Materials
O. I. Kit, E. M. Frantsiyants, I. A. Goroshinskaya, E. I. Surikova, V. A. Bandovkina, Yu. A. Pogorelova, L. A. Nemashkalova, D. E. Medvedeva, E. V. Shalashnaja, A. A. Maslov, Yu. S. Sidorenko   +10 more
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Structure of a human intramembrane ceramidase explains enzymatic dysfunction found in leukodystrophy

Nature Communications, 2018
Alkaline ceramidases (ACERs) are a class of poorly understood transmembrane enzymes controlling the homeostasis of ceramides. Here authors solve the Xray structure of human ACER3 and uncover a Ca2+ binding site providing an explanation for the known ...
Ieva Vasiliauskaité-Brooks, Robert D. Healey, Pascal Rochaix, Julie Saint-Paul, Rémy Sounier, Claire Grison, Thierry Waltrich-Augusto, Mathieu Fortier, François Hoh, Essa M. Saied, Christoph Arenz, Shibom Basu, Cédric Leyrat, Sébastien Granier   +13 more
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PPARβ/δ priming enhances the anti-apoptotic and therapeutic properties of mesenchymal stromal cells in myocardial ischemia–reperfusion injury

Stem Cell Research & Therapy, 2022
Background Mesenchymal Stromal Cells (MSC) have been widely used for their therapeutic properties in many clinical applications including myocardial infarction.
Charlotte Sarre, Rafael Contreras-Lopez, Nitirut Nernpermpisooth, Christian Barrere, Sarah Bahraoui, Claudia Terraza, Gautier Tejedor, Anne Vincent, Patricia Luz-Crawford, Kantapich Kongpol, Sarawut Kumphune, Christophe Piot, Joel Nargeot, Christian Jorgensen, Farida Djouad, Stéphanie Barrere-Lemaire   +15 more
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Modeling and separate exclusion of disturbances in terrestrial observations

Геофизический журнал, 2013
The technique of a separate deletion of linear and anomalous nonlinear drift of earth tides observations for diurnal and semidiurnal waves are presented.
A.M. Kutnyi, V. Pavlik, T. Babich
doaj   +1 more source