Results 21 to 30 of about 151,710 (240)
IGF-1 Gene Polymorphism and its Association with Cashmere Fiber Trait in Changthangi Goats
Journal of Natural Fibers, 2020 The Cashmere (Pashmina) fiber attracts great demand worldwide for its fineness. To identify and determine the role of Insulin-like Growth Factor-1 (IGF-1) gene polymorphism on Pashmina fiber traits (quality and quantity), exon IV, and part of intron IV ...
Syed Shanaz +7 more
doaj +1 more source
AIMTOR, a BRET Biosensor for Live Recording of mTOR Activity in Cell Populations and Single Cells
Bio-Protocol, 2021 Mammalian target of rapamycin (mTOR) controls many crucial cellular functions, including protein synthesis, cell size, energy metabolism, lysosome and mitochondria biogenesis, and autophagy.
Nathalie Bouquier +3 more
doaj +1 more source
Translational Oncology, 2021 Progastrin is an unprocessed soluble peptide precursor with a well-described tumor-promoting role in colorectal cancer. It is expressed at small levels in the healthy intestinal mucosa, and its expression is enhanced at early stages of intestinal tumor ...
J. Giraud +15 more
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Mouse spinal cord cellular mapping of dopamine D2 receptors-containing cells
Frontiers in NeuroanatomyThe spinal cord (SC) serves as the primary relay for sensory information originating in the periphery and transmitted to the brain for processing. Sensitive primary afferent fibers project to the dorsal horn, which contains a highly diverse array of ...
Pauline Tarot +5 more
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Membranes, 2023 G-protein coupled receptors (GPCRs) are versatile signaling proteins that regulate key physiological processes in response to a wide variety of extracellular stimuli. The last decade has seen a revolution in the structural biology of clinically important
Aurélien Fouillen +4 more
doaj +1 more source
Nutritional Regulation of IGF-I and IGF Binding Proteins
Annual Review of Nutrition, 1991 "The insulin-like growth factors (IGF-I and IGF-II) are small polypeptides (Mr -7500) that control growth of multiple cell types. Cells derived from all three embryonic lineages contain IGF receptors, and almost all cell types have been shown to respond to IGFs (79).
D R, Clemmons, L E, Underwood
openaire +3 more sources
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
تأثیر دما بر ساختار فاکتور رشد شبهانسولینی (IGF-1) و مطالعهای مبتنی بر شبیهسازی با روشهای دینامیک مولکولی و محاسبات کامپیوتری [PDF]
مجله دانشگاه علوم پزشکی سبزوار, 1970 زمینه و هدف: فاکتور رشد شبهانسولینی بهطور طبیعی در سیستم عصبی مرکزی (CNS) موجود است و نقش مهمی در تکثیر و تمایز سلولی در طی رشد و بلوغ مغز دارد. این فاکتورها بههمراه پروتئینهای پیوند به آنها و گیرندههایشان در نواحی آسیب دیدهی مغز بیان میشوند که ...
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