Results 51 to 60 of about 150,785 (321)

GLP-1 and GIP receptors signal through distinct β-arrestin 2-dependent pathways to regulate pancreatic β cell function

Cell Reports, 2023
Summary: Glucagon-like peptide 1 (GLP-1R) and glucose-dependent insulinotropic polypeptide (GIPR) receptors are G-protein-coupled receptors involved in glucose homeostasis. Diabetogenic conditions decrease β-arrestin 2 (ARRB2) levels in human islets.
Nour Zaïmia, Joelle Obeid, Annie Varrault, Julia Sabatier, Christophe Broca, Patrick Gilon, Safia Costes, Gyslaine Bertrand, Magalie A. Ravier   +8 more
doaj  

Activation of different growth factor systems in tissues of adenocarcinoma and signet-ring cell carcinoma of the stomach

Исследования и практика в медицине, 2019
Purpose of the study. The purpose of the study was to find the difference between local levels of VEGF, EGF, IGFI and IG- FII in tumor and intact tissues in adenocarcinoma of the stomach (AC) and signet-ring cell carcinoma of the stomach (SRCC).Materials
O. I. Kit, E. M. Frantsiyants, I. A. Goroshinskaya, E. I. Surikova, V. A. Bandovkina, Yu. A. Pogorelova, L. A. Nemashkalova, D. E. Medvedeva, E. V. Shalashnaja, A. A. Maslov, Yu. S. Sidorenko   +10 more
doaj   +1 more source

The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges

Advanced Science, EarlyView.
This paper summarizes the potential of biomaterials, stem cells, and gene editing technologies in the regeneration of inner ear hair cells, spiral ganglion neurons, and inner ear organoids. Challenges and potential developments are discussed and explored.
Zhe Li, Ying Zhang, Zhenyu Xiao, Jieyu Qi   +3 more
wiley   +1 more source

Pharmacological evidence for a metabotropic glutamate receptor heterodimer in neuronal cells

eLife, 2017
Metabotropic glutamate receptors (mGluRs) are mandatory dimers playing important roles in regulating CNS function. Although assumed to form exclusive homodimers, 16 possible heterodimeric mGluRs have been proposed but their existence in native cells ...
David Moreno Delgado, Thor C Møller, Jeanne Ster, Jesús Giraldo, Damien Maurel, Xavier Rovira, Pauline Scholler, Jurriaan M Zwier, Julie Perroy, Thierry Durroux, Eric Trinquet, Laurent Prezeau, Philippe Rondard, Jean-Philippe Pin   +13 more
doaj   +1 more source

Procedures for Culturing and Genetically Manipulating Murine Hippocampal Postnatal Neurons

Frontiers in Synaptic Neuroscience, 2020
Neuronal hippocampal cultures are simple and valuable models for studying neuronal function. While embryonic cultures are widely used for different applications, mouse postnatal cultures are still challenging, lack reproducibility and/or exhibit ...
Enora Moutin, Anne-Laure Hemonnot, Anne-Laure Hemonnot, Vincent Seube, Vincent Seube, Nathalie Linck, Nathalie Linck, François Rassendren, François Rassendren, Julie Perroy, Vincent Compan, Vincent Compan   +11 more
doaj   +1 more source

3D Building Adjustment Using Planar Half-Space Regularities [PDF]

ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2014
The automatic reconstruction of 3D building models with complex roof shapes is still an active area of research. In this paper we present a novel approach for local and global regularization rules that integrate building knowledge to improve both the ...
A. Wichmann, M. Kada
doaj   +1 more source

PRMT1 Ablation in Endothelial Cells Causes Endothelial Dysfunction and Aggravates COPD Attributable to Dysregulated NF‐κB Signaling

Advanced Science, EarlyView.
This study investigates the role of protein arginine methyltransferase 1 (PRMT1) in endothelial cells (ECs) in chronic obstructive pulmonary disease (COPD). Mice with endothelial‐specific PRMT1 deletion develop pulmonary hemorrhage, inflammation, and apoptosis, driven by excessive nuclear factor kappa B activation.
Thi Thuy Vy Tran, Yideul Jeong, Suwoo Kim, Ji Eun Yeom, Jinwoo Lee, Wonhwa Lee, Gyu‐Un Bae, Jong‐Sun Kang   +7 more
wiley   +1 more source

Wiring the senses: Factors that regulate peripheral axon pathfinding in sensory systems

Developmental Dynamics, Volume 252, Issue 1, Page 81-103, January 2023., 2023
Abstract Sensory neurons of the head are the ones that transmit the information about the external world to our brain for its processing. Axons from cranial sensory neurons sense different chemoattractant and chemorepulsive molecules during the journey and in the target tissue to establish the precise innervation with brain neurons and/or receptor ...
Gemma Nomdedeu‐Sancho, Berta Alsina
wiley   +1 more source

SUB-SURFACE GROWING AND BOUNDARY GENERALIZATION FOR 3D BUILDING RECONSTRUCTION [PDF]

ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2012
The automatic reconstruction of 3D building models from airborne point cloud data is still an ongoing research topic. Especially for complex roof shapes, the identification of sub-shapes, the generation of roof boundaries and the construction to well ...
M. Kada, A. Wichmann
doaj   +1 more source

Conditional Overexpression of Serpine2 Promotes Hair Cell Regeneration from Lgr5+ Progenitors in the Neonatal Mouse Cochlea

Advanced Science, EarlyView.
This study indicates that Serpine2 plays a pivotal role in hair cell (HC) regeneration from Lgr5+ progenitors in the neonatal mouse cochlea. Conditional overexpression of Serpine2 in cochlear Lgr5+ progenitors results in a significantly increased number of ectopic HCs, particularly ectopic inner HCs, and these HCs are likely derived from Lgr5 ...
Hairong Xiao, Jiheng Wu, Lixuan Huang, Ying Ma, Leilei Wu, Yanqin Lin, Zixuan Ye, Xin Tan, Xujun Tang, Wei Tong, Mingchen Dai, Yintao Wang, Xia Sheng, Renjie Chai, Shasha Zhang   +14 more
wiley   +1 more source