Results 101 to 110 of about 1,067,036 (373)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Estimating daily semantic segmentation maps of classified ocean eddies using sea level anomaly data from along-track altimetry

Frontiers in Artificial Intelligence
Mesoscale eddies, which are fast-moving rotating water bodies in the ocean with horizontal scales ranging from 10 km to 100 km and above, are considered to be the weather of the oceans.
Eike Bolmer, Adili Abulaitijiang, Jürgen Kusche, Ribana Roscher, Ribana Roscher   +4 more
doaj   +1 more source

IgG Adhesion on Hydrophobic Surfaces: Theory, Modelling, and Application to ELISA [PDF]

arXiv, 2016
Enzyme-Linked ImmunoSorbent Assays (ELISA) are a range of widely used analytical methods whose implementation requires to build antibodies (IgG) thin films onto surfaces predominantly made of polystyrene. The high hydrophobicity of polystyrene ensures a spontaneous and strong adhesion of proteins allowing to easily build IgG monolayers. Since the ELISA
arxiv  

Beyond Vaccination Rates: A Synthetic Random Proxy Metric of Total SARS-CoV-2 Immunity Seroprevalence in the Community [PDF]

arXiv, 2022
Explicit knowledge of total community-level immune seroprevalence is critical to developing policies to mitigate the social and clinical impact of SARS-CoV-2. Publicly available vaccination data are frequently cited as a proxy for population immunity, but this metric ignores the effects of naturally-acquired immunity, which varies broadly throughout ...
arxiv  

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Modulating IgG effector function by Fc glycan engineering

Proceedings of the National Academy of Sciences of the United States of America, 2017
Significance The N-glycan composition of the constant (Fc) domain of IgG can modulate antibody effector functions by affecting the ability of the Fc to bind various Fc receptors (FcγRs).
Tiezheng Li, D. DiLillo, S. Bournazos, John P. Giddens, J. Ravetch, Lai-Xi Wang   +5 more
semanticscholar   +1 more source

Lymphocyte membrane IgG and secreted IgG are structurally and allotypically distinct. [PDF]

The Journal of experimental medicine, 1980
We have demonstrated that there are structurally distinct membrane and secreted IgG2a immunoglobulin molecules. The membrane heavy chain is both larger and more acidic than the secreted molecule. This difference is not a result of different N-glycosidic-linked oligosaccharide chains.
V T, Oi, V M, Bryan, L A, Herzenberg, L A, Herzenberg   +3 more
openaire   +3 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

The Imperative of Co-existence

Technophany
In this article I examine the problem of technique in Georges Bataille's social ontology by means of a counterpoint with Bernard Stiegler's philosophy. I will defend the following theses: 1.
Tomás Ramos Mejía
doaj   +1 more source

Bernardo Mançano Fernandes y el territorio como proceso espacial de construcción política.

Finisterra - Revista Portuguesa de Geografia, 2021
El territorio es un concepto de origen geográfico con más de un siglo de historia y desde hace varias décadas ha cobrado una notoria visibilidad en las Ciencias Sociales de Europa, Norteamérica y América Latina.
Guillermo Castillo Ramírez
doaj