Results 11 to 20 of about 2,339,252 (343)

In Silico Identification of Natural Product-Based Inhibitors Targeting IL-1β/IL-1R Protein–Protein Interface

Molecules, 2023
IL-1β mediates inflammation and regulates immune responses, cell proliferation, and differentiation. Dysregulation of IL-1β is linked to inflammatory and autoimmune diseases.
Ting-ting Liu, Yan-kun Chen, Muhammad Adil, Mazen Almehmadi, Fahad M. Alshabrmi, Mamdouh Allahyani, Ahad Amer Alsaiari, Pei Liu, Muhammad Raheel Khan, Qinghua Peng   +9 more
doaj   +1 more source

Epithelial-derived gasdermin D mediates nonlytic IL-1β release during experimental colitis.

Journal of Clinical Investigation, 2020
Gasdermin D (GSDMD) induces pyroptosis via the pore-forming activity of its N-terminal domain, cleaved by activated caspases associated with the release of IL-1β.
K. Bulek, Junjie Zhao, Yun Liao, N. Rana, D. Corridoni, A. Antanaviciute, Xing Chen, Han Wang, Wen Qian, William A. Miller-Little, S. Swaidani, Fangqiang Tang, B. Willard, K. McCrae, Zizhen Kang, G. Dubyak, F. Cominelli, A. Simmons, T. Pizarro, Xiaoxia Li   +19 more
semanticscholar   +1 more source

Melatonin alleviates intervertebral disc degeneration by disrupting the IL-1β/NF-κB-NLRP3 inflammasome positive feedback loop

Bone Research, 2020
The inflammatory response is induced by the overexpression of inflammatory cytokines, mainly interleukin (IL)-1β, and is one of the main causes of intervertebral disc degeneration (IVDD).
Fan Chen, G. Jiang, Hui Liu, Zemin Li, Y. Pei, Hua Wang, H. Pan, Haowen Cui, Jun Long, Jianru Wang, Zhaomin Zheng   +10 more
semanticscholar   +1 more source

MOLECULAR BIOLOGY ANALYSIS OF IL -1Β, IL -4, AND IL -1Β RA GENE POLYMORPHISMS IN ETHNIC BASHKIR PATIENTS WITH RHEUMATOID ARTHRITIS, LIVING IN C HELYABINSK REGION

Медицинская иммунология, 2014
. Common polymorphisms of interleukin-1β, receptor antagonist interleukin-1, and interleukin-4 genes have been studied among the patients with rheumatoid arthritis of Bashkir origin, living in Chelyabinsk Region.
A. L. Burmistrova, D. S. Stashkevich, T. A. Susslova, I. V. Devald, A. O. Issakanova, O. N. Dimcheva   +5 more
doaj   +1 more source

Newcastle disease virus RNA-induced IL-1β expression via the NLRP3/caspase-1 inflammasome

Veterinary Research, 2020
Newcastle disease virus (NDV) infection causes severe inflammation and is a highly contagious disease in poultry. Virulent NDV strains (GM) induce large quantities of interleukin-1β (IL-1β), which is the central mediator of the inflammatory reaction ...
Pei Gao, Libin Chen, Lei Fan, Jinlian Ren, Haoyun Du, Minhua Sun, Yaling Li, Peng Xie, Qiuyan Lin, Ming Liao, Chenggang Xu, Zhangyong Ning, Chan Ding, Bin Xiang, Tao Ren   +14 more
doaj   +1 more source

D-mannose suppresses macrophage IL-1β production

Nature Communications, 2020
D-mannose is a monosaccharide approximately a hundred times less abundant than glucose in human blood. Previous studies demonstrated that supraphysiological levels of D-mannose inhibit tumour growth and stimulate regulatory T cell differentiation.
S. Torretta, A. Scagliola, L. Ricci, F. Mainini, Sabrina Di Marco, I. Cuccovillo, A. Kajaste-Rudnitski, D. Sumpton, K. Ryan, S. Cardaci   +9 more
semanticscholar   +1 more source

Betaine Inhibits Interleukin-1β Production and Release: Potential Mechanisms

Frontiers in Immunology, 2018
Betaine is a critical nutrient for mammal health, and has been found to alleviate inflammation by lowering interleukin (IL)-1β secretion; however, the underlying mechanisms by which betaine inhibits IL-1β secretion remain to be uncovered. In this review,
Yaoyao Xia, Yaoyao Xia, Yaoyao Xia, Shuai Chen, Shuai Chen, Guoqiang Zhu, Ruilin Huang, Yulong Yin, Yulong Yin, Yulong Yin, Wenkai Ren, Wenkai Ren   +11 more
doaj   +1 more source

IL-1β turnover by the UBE2L3 ubiquitin conjugating enzyme and HECT E3 ligases limits inflammation

Nature Communications, 2023
The cytokine interleukin-1β (IL-1β) has pivotal roles in antimicrobial immunity, but also incites inflammatory disease. Bioactive IL-1β is released following proteolytic maturation of the pro-IL-1β precursor by caspase-1.
Vishwas Mishra, Anna Crespo-Puig, Callum McCarthy, Tereza Masonou, Izabela Glegola-Madejska, Alice Dejoux, Gabriella Dow, Matthew J. G. Eldridge, Luciano H. Marinelli, Meihan Meng, Shijie Wang, Daniel J. Bennison, Rebecca Morrison, Avinash R. Shenoy   +13 more
doaj   +1 more source

Translocation of interleukin-1β into a vesicle intermediate in autophagy-mediated secretion

eLife, 2015
Recent evidence suggests that autophagy facilitates the unconventional secretion of the pro-inflammatory cytokine interleukin 1β (IL-1β). Here, we reconstituted an autophagy-regulated secretion of mature IL-1β (m-IL-1β) in non-macrophage cells.
Min Zhang, Samuel J Kenny, Liang Ge, Ke Xu, Randy Schekman   +4 more
doaj   +1 more source

Trimeric form of intracellular ATP synthase subunit β of Aggregatibacter actinomycetemcomitans binds human interleukin-1β. [PDF]

PLoS ONE, 2011
Bacterial biofilms resist host defenses and antibiotics partly because of their decreased metabolism. Some bacteria use proinflammatory cytokines, such as interleukin (IL)-1β, as cues to promote biofilm formation and to alter virulence.
Annamari Paino, Heidi Tuominen, Mari Jääskeläinen, Jonna Alanko, Jari Nuutila, Sirkka E Asikainen, Lauri J Pelliniemi, Marja T Pöllänen, Casey Chen, Riikka Ihalin   +9 more
doaj   +1 more source