Results 11 to 20 of about 2,610,317 (379)

Relationship between IL-6, IL-1β, and vitamin D on frailty status in elderly women

Bali Medical Journal, 2021
Background: The aging process is associated with an increase in proinflammatory markers' serum levels, indicating that a chronic inflammatory process is correlated with an increase in disability, mortality, and frailty. Pro-inflammatory cytokines that increase with the incidence of frailty syndrome are IL-6, IL-1β and TNF-α.
Dwi Ngestiningsih, Jessa Kris Dayanti, Lusiana Batubara   +2 more
openaire   +1 more source

In Silico Identification of Natural Product-Based Inhibitors Targeting IL-1β/IL-1R Protein–Protein Interface

Molecules, 2023
IL-1β mediates inflammation and regulates immune responses, cell proliferation, and differentiation. Dysregulation of IL-1β is linked to inflammatory and autoimmune diseases.
Ting-ting Liu, Yan-kun Chen, Muhammad Adil, Mazen Almehmadi, Fahad M. Alshabrmi, Mamdouh Allahyani, Ahad Amer Alsaiari, Pei Liu, Muhammad Raheel Khan, Qinghua Peng   +9 more
doaj   +1 more source

N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis

Nature Communications, 2020
Gasdermin-D (GSDMD) in inflammasome-activated macrophages is cleaved by caspase-1 to generate N-GSDMD fragments. N-GSDMD then oligomerizes in the plasma membrane (PM) to form pores that increase membrane permeability, leading to pyroptosis and IL-1β ...
Mausita Karmakar, Martin S Minns, Elyse Greenberg, Jose Diaz-Aponte, K. Pestonjamasp, J. Johnson, Joseph K. Rathkey, Derek W. Abbott, Kun Wang, F. Shao, S. Catz, G. Dubyak, E. Pearlman   +12 more
semanticscholar   +1 more source

Intracellular Chloride Concentration Changes Modulate IL-1β Expression and Secretion in Human Bronchial Epithelial Cultured Cells [PDF]

, 2017
Cystic fibrosis (CF) is caused by mutations in the CFTR gene, which encodes a cAMP‐regulated chloride channel. Several cellular functions are altered in CF cells. However, it is not clear how the CFTR failure induces those alterations.
Clauzure, Mariangeles, Dugour, Andrea Vanesa, Figueroa, Juan Manuel, Massip Copiz, María Macarena, Mori, Consuelo, Santa Coloma, Tomás Antonio, Valdivieso, Ángel Gabriel   +6 more
core   +1 more source

The expression of TNF-α, IL-1β, and IL-10 in the diabetes mellitus condition induced by the combination of spirulina and chitosan

Bali Medical Journal, 2020
Background: Rapid wound healing is needed after tooth extraction treatment so that prosthodontics treatment can be done immediately. However, systemic diseases, such as diabetes mellitus, can inhibit the wound healing process. The state of hyperglycemia in people with diabetes mellitus can interfere with the function of macrophages and neutrophils ...
Nike Hendrijantini, -, Ratri Maya Sitalaksmi, -, Muhammad Dimas Aditya Ari, -, Tiffany Josephine Hidayat, -, Prisca Agustina Nurcahyani Putri, -, Daniel Sukandar, -   +5 more
openaire   +1 more source

Ursolic acid enhances macrophage autophagy and attenuates atherogenesis [PDF]

, 2016
Macrophage autophagy has been shown to be protective against atherosclerosis. We previously discovered that ursolic acid (UA) promoted cancer cell autophagy.
Fan, Daping, Iwanowycz, Stephen, Leng, Shuilong, Razani, Babak, Saaoud, Fatma, Sergin, Ismail, Wang, Junfeng, Wang, Yuzhen   +7 more
core   +2 more sources

Nox2 dependent redox-regulation of microglial response to amyloid-β stimulation and microgliosis in aging [PDF]

, 2020
Microglia express constitutively a Nox2 enzyme that is involved in neuroinflammation by the generation of reactive oxygen species (ROS). Amyloid β (Aβ) plays a crucial role in Alzheimer’s disease.
Fan, Lampson M., Geng, Li, Li, Jian-mei, Liu, Fangfei, Smith, Colin   +4 more
core   +2 more sources

Tumor Cell-Derived IL-1β Promotes Desmoplasia and Immune Suppression in Pancreatic Cancer.

Cancer Research, 2020
Pancreatic ductal adenocarcinoma (PDA) is an aggressive malignancy typified by a highly stromal and weakly immunogenic tumor microenvironment that promotes tumor evolution and contributes to therapeutic resistance.
Shipra Das, Beny Shapiro, E. Vucic, Sandra Vogt, D. Bar-Sagi   +4 more
semanticscholar   +1 more source

Newcastle disease virus RNA-induced IL-1β expression via the NLRP3/caspase-1 inflammasome

Veterinary Research, 2020
Newcastle disease virus (NDV) infection causes severe inflammation and is a highly contagious disease in poultry. Virulent NDV strains (GM) induce large quantities of interleukin-1β (IL-1β), which is the central mediator of the inflammatory reaction ...
Pei Gao, Libin Chen, Lei Fan, Jinlian Ren, Haoyun Du, Minhua Sun, Yaling Li, Peng Xie, Qiuyan Lin, Ming Liao, Chenggang Xu, Zhangyong Ning, Chan Ding, Bin Xiang, Tao Ren   +14 more
doaj   +1 more source

IL-1β turnover by the UBE2L3 ubiquitin conjugating enzyme and HECT E3 ligases limits inflammation

Nature Communications, 2023
The cytokine interleukin-1β (IL-1β) has pivotal roles in antimicrobial immunity, but also incites inflammatory disease. Bioactive IL-1β is released following proteolytic maturation of the pro-IL-1β precursor by caspase-1.
Vishwas Mishra, Anna Crespo-Puig, Callum McCarthy, Tereza Masonou, Izabela Glegola-Madejska, Alice Dejoux, Gabriella Dow, Matthew J. G. Eldridge, Luciano H. Marinelli, Meihan Meng, Shijie Wang, Daniel J. Bennison, Rebecca Morrison, Avinash R. Shenoy   +13 more
doaj   +1 more source