Results 41 to 50 of about 2,339,252 (343)

ATP-Induced IL-1β Specific Secretion: True Under Stringent Conditions [PDF]

Frontiers in Immunology, 2015
Interleukin-1β is a potent proinflammatory cytokine, of which processing and secretion are tightly regulated. After exposure to various stimuli, mononuclear phagocytes synthesize the inactive precursor (pro-IL-1β), which is then cleaved intracellularly by caspase-1 and secreted.
Monique eStoffels, Monique eStoffels, Ruben eZaal, Ruben eZaal, Nina eKok, Nina eKok, Jos W.M. van der Meer, Jos W.M. van der Meer, Charles A. Dinarello, Charles A. Dinarello, Anna eSimon, Anna eSimon   +11 more
openaire   +6 more sources

Blocking IL-1β reverses the immunosuppression in mouse breast cancer and synergizes with anti–PD-1 for tumor abrogation

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Inflammation and immunosuppression are dominant features of cancer progression. In the tumor microenvironment, macrophages produce interleukin-1β (IL-1β), which subsequently recruits myeloid cells from the bone marrow.
Irena Kaplanov, Yaron Carmi, R. Kornetsky, A. Shemesh, G. Shurin, M. Shurin, C. Dinarello, E. Voronov, R. Apte   +8 more
semanticscholar   +1 more source

IL-1β neutralization prevents diastolic dysfunction development, but lacks hepatoprotective effect in an aged mouse model of NASH

Scientific Reports, 2023
Interleukin-1β (IL-1β) is a key mediator of non-alcoholic steatohepatitis (NASH), a chronic liver disease, and of systemic inflammation-driven aging.
Dániel Kucsera, Viktória E. Tóth, Nabil V. Sayour, Tamás Kovács, Tamás G. Gergely, Mihály Ruppert, Tamás Radovits, Alexandra Fábián, Attila Kovács, Béla Merkely, Péter Ferdinandy, Zoltán V. Varga   +11 more
doaj   +1 more source

Additional file 2: Table S1. of IL-1β mediates lung neutrophilia and IL-33 expression in a mouse model of viral-induced asthma exacerbation

, 2018
Commercially available primer sequences for genes analysed with RT-qPCR. (DOCX 13 kb)
Persson, Irma Mahmutovic, Menzel, Mandy, Sangeetha Ramu, Cerps, Samuel, Akbarshahi, Hamid, Uller, Lena   +5 more
openaire   +1 more source

Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1β in the aged hippocampus [PDF]

Proceedings of the National Academy of Sciences, 2015
Significance There is a growing understanding that inflammation impairs synaptic plasticity and cognition and that the aged brain has an elevated sensitivity to cognitive impairment by the proinflammatory cytokine interleukin 1β (IL-1β). IL-1β activates different pathways via AcP (proinflammatory) or AcPb (prosurvival) IL-1 receptor subunits.
David Baglietto-Vargas, Nicole C. Berchtold, Shikha Snigdha, Liqi Tong, G. Aleph Prieto, Erica D. Smith, Dariush Ajami, Carl W. Cotman, Julius Rebek, Julius Rebek, Frank M. LaFerla   +10 more
openaire   +6 more sources

Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance The molecular clock provides an anticipatory mechanism, allowing organisms to prepare and respond to daily changes in the external environment.
James O. Early, Deepthi Menon, C. Wyse, Mariana P. Cervantes-Silva, Z. Zaslona, R. Carroll, E. Palsson-McDermott, Stefano Angiari, D. Ryan, Sarah E. Corcoran, George A. Timmons, S. Geiger, Darren J. Fitzpatrick, Daniel J. O'Connell, R. Xavier, K. Hokamp, L. O’Neill, Annie M. Curtis   +17 more
semanticscholar   +1 more source

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

A balanced IL-1β activity is required for host response to Citrobacter rodentium infection. [PDF]

PLoS ONE, 2013
Microbial sensing plays essential roles in the innate immune response to pathogens. In particular, NLRP3 forms a multiprotein inflammasome complex responsible for the maturation of interleukin (IL)-1β.
Misagh Alipour, Yuefei Lou, Daniel Zimmerman, Michael W Bording-Jorgensen, Consolato Sergi, Julia J Liu, Eytan Wine   +6 more
doaj   +1 more source

Additional file 1: Figure S1. of E2 regulates MMP-13 via targeting miR-140 in IL-1β-induced extracellular matrix degradation in human chondrocytes

, 2016
The expression of MMP-13 mRNA level increased in five OA patientsâ articular cartilage tissues. Quantitative reverse transcription-polymerase chain reaction analysis of the matrix metalloproteinase 13 (MMP-13) in articular cartilage tissues from five patients with OA. Figure S2.
Yujie Liang, Duan, Li, Jianyi Xiong, Weiming Zhu, Qisong Liu, Daming Wang, Liu, Wei, Zigang Li, Daping Wang   +8 more
openaire   +1 more source

Diphthamide synthesis is linked to the eEF2‐client chaperone machinery

FEBS Letters, EarlyView.
The diphthamide modification of eukaryotic translation elongation factor 2 (eEF2) is important for accurate protein synthesis. We addressed the potential coordination of de novo eEF2 synthesis with simultaneous or subsequent diphthamide modification. Our work reveals that the co‐chaperones Hgh1 and Cpr7, which are known to support folding of nascent ...
Lars Kaduhr, Klaus Mayer, Raffael Schaffrath, Johannes Buchner, Ulrich Brinkmann   +4 more
wiley   +1 more source