Results 171 to 180 of about 1,850,686 (245)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

32. The Value of the Independent Program Training Pathway

Plastic and Reconstructive Surgery, Global Open
Ariel E. Figueroa, MD, Umer Qureshi, MEd, Taylor Hallman, Jason Zhang, MD, Arun K. Gosain, MD   +4 more
doaj   +1 more source

IL-1 protects from fatal systemic candidiasis in mice by inhibiting oxidative phosphorylation and hypoxia. [PDF]

Nat Commun
Horn S, Schmid M, Berest I, Piattini F, Zhang J, de Bock K, Devuyst O, Nlandu Khodo S, Kisielow J, Kopf M.   +9 more
europepmc   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

22. Enhancing The Accuracy Of Planned Surgery With Computer Controlled Osteotomies

Plastic and Reconstructive Surgery, Global Open
Naji Bou Zeid, MD, Devansh Saini, PhD, George R. Nahass, BS, Weiqiao Zeng, PhD, He Tong-Chuan, PhD, Russel R. Reid, MD, PhD, Pravin K. Patel, MD, Lee Alkureishi, MD   +7 more
doaj   +1 more source

Pilot Study of IL-1 Antagonist Anakinra for Treatment of Endometriosis. [PDF]

Int J Womens Health
Sullender RT, Agarwal RK, Jacobs MB, Wessels JM, Foster WG, Agarwal SK.   +5 more
europepmc   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

SO27. First Rib-Sparing Vs. Rib Resection in Thoracic Outlet Syndrome: Functional Outcomes in 105 Patients

Plastic and Reconstructive Surgery, Global Open
Iulianna Taritsa, BA, Kazimir Bagdady, BS, Cristin Coquillard, MD, Hannah Soltani, BS, Rolando Casas Fuentes, BS, Timothy Burke, BA, Rushmin Khazanchi, BA, Puja Jagasia, BA, Lindsay Janes, MD, Ashley Vavra, MD, Jason H. Ko, MD, MBA, FACS   +10 more
doaj   +1 more source

IL-1 modulation preserves biomolecular, structural and functional integrity of the somatosensory cortex after fetal inflammation

Galinsky R, Kelly S, Cho S, Zahra V, Menyen M, Hunt R, Nold-Petry C, Gunn A, Polglase G, Hooper S, Nold M.   +10 more
europepmc   +1 more source

BET bromodomain inhibitors attenuate transcription of a subset of IL-1-induced NF-κB targets that promote inflammation in β-cells. [PDF]

J Biol Chem
Nord JA, Makowski SJ, Sidlowski PFW, Bursch KL, Corbett JA, Smith BC.   +5 more
europepmc   +1 more source