Results 151 to 160 of about 34,732,115 (289)

IL-16 regulation of humanmast cells/basophils and their susceptibility to HIV-1

, 2002
AIDS patients often contain HIV-1-infected mast cells (MCs)/basophils in their peripheral blood, and in vivo-differentiated MCs/basophils have been isolated from the blood of asthma patients that are HIV-1 susceptible ex vivo due to their surface ...
Roufogalis, B (15570794), Krilis, SA (15570797), Wanigasek, Y (15570791), Naif, HM (15570779), Nasr, N (15570782), Katsoulotos, G (15570788), Cooley, MA (15533384), Qi, JC (15502772), Wadley, R (15570776), Cunningham, A (15570785), Collins, A (15507884), Stevens, RL (15570773)   +11 more
core  

IL-1 Blockade to Resolve Persistent Inflammation After STEMI. [PDF]

JACC Basic Transl Sci
Del Buono MG, Golino M, Abbate A.
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Cardioimmunology of Myocarditis: Targeting the IL-1 Pathway. [PDF]

Curr Cardiol Rep
Chiara E, Pieroni M, Obeid M, Emmi G, Malandrino D.   +4 more
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Chronic IL-1 Exposure Attenuates IL-1 Response and Alters Gene Expression Regulation While Maintaining Therapeutic Sensitivity in BCa Cell Lines. [PDF]

Int J Mol Sci
Falah R, Dhar R, Yamauchi S, Bautista M, Kanchwala M, Yan L, Raju D, Xu L, Reliford K, Nawas A, Ali S, Fang J, Olaleye O, Tera J, Abdelaziz R, Kanakala R, Sudunagunta A, Eedarapali S, Burr E, Mansoor BS, Roos N, Diep S, Afaq H, Rajesh NP, Manohar S, Odikpo J, Jain AK, Xuan Z, Xing C, Delk NA.   +29 more
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

IL-1-Activated Inflammatory Cardiac Fibroblasts Exacerbate Acute Coxsackievirus B3 Myocarditis. [PDF]

JACC Basic Transl Sci
Elias DS, Jo W, Talor MV, Jaime C, Daoud A, Sulkaj I, Květoň M, Wang N, Fabián O, Melenovský V, Čiháková D.   +10 more
europepmc   +1 more source

Editorial: IL-1 Inhibition [PDF]

Frontiers in Pharmacology, 2019
Oliviero, Francesca, Sfriso, Paolo, Punzi, Leonardo, Dayer, Jean-Michel   +3 more
openaire   +5 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source