Results 151 to 160 of about 111,339,475 (290)

Chronic IL-1 Exposure Attenuates IL-1 Response and Alters Gene Expression Regulation While Maintaining Therapeutic Sensitivity in BCa Cell Lines. [PDF]

Int J Mol Sci
Falah R, Dhar R, Yamauchi S, Bautista M, Kanchwala M, Yan L, Raju D, Xu L, Reliford K, Nawas A, Ali S, Fang J, Olaleye O, Tera J, Abdelaziz R, Kanakala R, Sudunagunta A, Eedarapali S, Burr E, Mansoor BS, Roos N, Diep S, Afaq H, Rajesh NP, Manohar S, Odikpo J, Jain AK, Xuan Z, Xing C, Delk NA.   +29 more
europepmc   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Long COVID shows IL-1 pathway dysregulation without a discrete circulating biomarker signature. [PDF]

Front Immunol
Muñoz-López F, Flores-Santamaría M, Santano R, Trigueros M, Riveira-Muñoz E, Cabrero de Las Heras S, Banaei G, Pradenas E, Trinité B, Marfil S, Gervassi A, Urrea V, Izquierdo-Pujol J, Loste C, Santos JR, Lladós G, Aiello TF, Chamorro A, Jiménez A, Dobaño C, Paredes R, Blanco J, Ballana E, Moncunill G, Mateu L, Nevot M, Massanella M.   +26 more
europepmc   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Serum IL-1β and IL-17 levels in patients with COPD: associations with clinical parameters

, 2017
Yong Zou,1 Xi Chen,1 Jie Liu,2 Dong bo Zhou,1 Xiao Kuang,1 Jian Xiao,1 Qiao Yu,1 Xiaoxiao Lu,1 Wei Li,1 Bin Xie,1 Qiong Chen1 1Department of Geriatrics, Respiratory Medicine, Xiangya Hospital of Central South University, 2Department of Emergency, The ...
Zhou DB, Li W, Zou Y, Liu J, Chen Q, Lu XX, Xiao J, Yu Q, Chen X, Kuang X, Xie B   +10 more
core  

FOSL1-associated condensates modulate superenhancer-mediated selected IL-1 family gene activation in psoriasis. [PDF]

Sci Adv
Qiu Y, Sun K, Yu Y, Hou H, Wu R, Lu Q, Zhao M.   +6 more
europepmc   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

IL-1-Activated Inflammatory Cardiac Fibroblasts Exacerbate Acute Coxsackievirus B3 Myocarditis. [PDF]

JACC Basic Transl Sci
Elias DS, Jo W, Talor MV, Jaime C, Daoud A, Sulkaj I, Květoň M, Wang N, Fabián O, Melenovský V, Čiháková D.   +10 more
europepmc   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

D113. Comparison of Methodologies for Craniofacial Soft-tissue Cephalometrics: The Value of Virtual Reality

Plastic and Reconstructive Surgery, Global Open, 2023
John Vandevender, BS, Akriti Choudhary, MBBS, Sobhi Kazmouz, BA, Marina A. Lentskevich, BS, Michael Edgar, DC, Christopher Juarez, BS, Julius Mendoza, Kevin Yang, MD, Kyle Bartelt, MD, Alvin Nguyen, BA, Chad A. Purnell, MD   +10 more
doaj   +1 more source