Results 131 to 140 of about 111,339,475 (290)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Development of IL-17A-associated autoimmunity [PDF]

, 2010
Autoimmunity results from a breakdown in tolerance to self-antigens. Interleukin-17A (IL-17A) is a cytokine that has been implicated in the development of certain autoimmune disorders, notably multiple sclerosis and its mouse model experimental ...
Hornsby, E.
core  

D46. US Insurance Coverage of Lymphatic Microsurgical Preventing Healing Approach: A Critical Review

Plastic and Reconstructive Surgery, Global Open, 2023
Okensama M. LaAnyane, BS, Kelly A. Harmon, BS, Jocelyn To, BS, Brandon Alba, MPH, MD, Harry Siotos, MD PhD, David Kurlander, MD, Deana Shenaq, MD, Rosalinda Alvarado, MD, Andrea Madrigrano, MD, Cristina O’Donoghue, MD, MPH, Claudia B. Perez, DO, Amir Dorafshar, MD, George Kokosis, MD   +12 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

La recensione / 1 – Il testo in traduzione? Solo una tessera di un mosaico [Recensione a Traduzione e paratesto]

, 2015
La recensione si occupa del libro di Chiara Elefante sul Paratesto, in particolare sull'uso delle note apposte dal traduttore nelle edizioni italine di romanzi francesi degli ultimi anni.
NASI, Franco
core  

P21. INCORPORATION OF DECELLULARIZED EXTRACELLULAR MATRIX IN 3D-PRINTED GRAPHENE-BASED SCAFFOLDS FOR TREATMENT OF VOLUMETRIC MUSCLE LOSS

Plastic and Reconstructive Surgery, Global Open, 2022
Carlos Serna, III, PhD, Rebecca Keate, BS, Sophia L. Zhang, BS, Kristen Cotton, BS, Alberto De La Isla, BS, Yasmine Bouricha, BS, Colin Franz, MD, PhD, Sumanas Jordan, MD, PhD   +7 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

44. The Effect of Acellular Dermal Matrix on Skin Growth and Collagen Deposition Induced by Tissue Expansion

Plastic and Reconstructive Surgery, Global Open, 2023
Joanna K. Ledwon, PhD, Sarah A. Applebaum, MD, Bianka Progri, MS, Tianhong Han, BS, Oveyaa Vignesh, MS, Kristof S. Gutowski, BS, Alec B. Chang, BA, Adrian B. Tepole, PhD, Arun K. Gosain, MD   +8 more
doaj   +1 more source