Results 141 to 150 of about 34,732,115 (289)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

P21. INCORPORATION OF DECELLULARIZED EXTRACELLULAR MATRIX IN 3D-PRINTED GRAPHENE-BASED SCAFFOLDS FOR TREATMENT OF VOLUMETRIC MUSCLE LOSS

Plastic and Reconstructive Surgery, Global Open, 2022
Carlos Serna, III, PhD, Rebecca Keate, BS, Sophia L. Zhang, BS, Kristen Cotton, BS, Alberto De La Isla, BS, Yasmine Bouricha, BS, Colin Franz, MD, PhD, Sumanas Jordan, MD, PhD   +7 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Come cambierà il dispositivo europeo antiriciclaggio alla luce del recentissimo Action Plan lanciato dalla Commissione?

, 2020
1. Abstract Il 7 maggio 2020, il Vice Presidente Esecutivo della Commissione Europea Valdis Dombrovskis, in occasione della presentazione del Piano di Azione contro il riciclaggio e il finanziamento del terrorismo, ha dichiarato «Dobbiamo porre fine ...
Marco Letizi
core  

44. The Effect of Acellular Dermal Matrix on Skin Growth and Collagen Deposition Induced by Tissue Expansion

Plastic and Reconstructive Surgery, Global Open, 2023
Joanna K. Ledwon, PhD, Sarah A. Applebaum, MD, Bianka Progri, MS, Tianhong Han, BS, Oveyaa Vignesh, MS, Kristof S. Gutowski, BS, Alec B. Chang, BA, Adrian B. Tepole, PhD, Arun K. Gosain, MD   +8 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Curare adeguatamente il dolore cronico significa tutelare l'inalenabile diritto alla dignità del malato

, 2009
La malignità sociale del dolore cronico: un concetto emergente ma sottovalutato Nel 2001, l’Organizzazione mondiale della sanità pubblicò l’annuale World health report che ha classificato le malattie non solo secondo il criterio di mortalità e
Evangelista, Maurizio
core  

Bladder Cancer Cells Maintain Paracrine IL-1 Signaling and IL-1Ra Sensitivity Following Chronic IL-1 Exposure. [PDF]

Cells
Gomez J, Lakew M, Wilkie H, David B, Taiwo O, Dhar R, Akula A, Thasma A, Cho J, Sharma N, Okafor O, Delk NA.   +11 more
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source