Results 171 to 180 of about 34,732,115 (289)

Evaluation of the Effect of IL-1 Antagonists on Pituitary Function. [PDF]

Int J Endocrinol
Aktas Koc F, Sariakcali B, Sahin A.
europepmc   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

QS75. Bone Bending: Developing an Animal Model For Mechanical Properties of Human Infant Calvarium

Plastic and Reconstructive Surgery, Global Open, 2022
Devansh Saini, PhDc, Lee Alkureishi, MD, Russell Reid, MD, PhD, Pravin Patel, MD, Linping Zhao, PhD, Roberto Leonardo Diaz, PhD, Farid Amirouche, PhD   +6 more
doaj   +1 more source

Nanomaterial-Based Strategies Targeting IL-1 Signalling in Inflammatory Bowel Disease: Therapeutic Applications and Mechanistic Insights. [PDF]

J Inflamm Res
Wang K, Chen S, Zhang J, Du J, Liu Y, Li D, Sun X, Song Y.   +7 more
europepmc   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Molecular cytokine-dependent mechanisms of periodontitis pathogenesis and the potential for pharmacological IL-1 modulation in disease treatment. [PDF]

Front Dent Med
Belenichev I, Popazova O, Dmytriieva O, Chertov S, Bukhtiyarova N, Ryzhenko V, Oliynyk S, Lee S, Yi KH.   +8 more
europepmc   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

TNFα and Endothelial IL-1 Receptor Signaling Drive Peritubular Capillary Regression and Collagen Remodeling in Obstructive Kidney Injury. [PDF]

Am J Physiol Renal Physiol
Johnson CF, Wheeler K, Xie J, Chan J, Davis GE, Griffin CT.   +5 more
europepmc   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Case Report: From idiopathic recurrent pericarditis to systemic Behçet's Disease: unmasking a unified IL-1-driven autoinflammatory phenotype. [PDF]

Front Immunol
Emanuele B, Angela M, Germinario C, Francesca C, Silvia B, Stefano M, Antonio G, Giuseppina M, Maria MA, Sara R, Elisabetta G, Stella M, Francesco P, Martina S, Sarah D, Giulia A, Caterina G, Patrizia RQ, Antonio B.   +18 more
europepmc   +1 more source