Results 181 to 190 of about 1,896,687 (246)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IL-1 Superfamily Across 400+ Species: Therapeutic Targets and Disease Implications. [PDF]

Biology (Basel)
Wang W, Li D, Luo K, Chen B, Hao T, Li X, Guo D, Dong Y, Ning Y.   +8 more
europepmc   +1 more source

SO27. First Rib-Sparing Vs. Rib Resection in Thoracic Outlet Syndrome: Functional Outcomes in 105 Patients

Plastic and Reconstructive Surgery, Global Open
Iulianna Taritsa, BA, Kazimir Bagdady, BS, Cristin Coquillard, MD, Hannah Soltani, BS, Rolando Casas Fuentes, BS, Timothy Burke, BA, Rushmin Khazanchi, BA, Puja Jagasia, BA, Lindsay Janes, MD, Ashley Vavra, MD, Jason H. Ko, MD, MBA, FACS   +10 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

SP08. Uncovering the Socioeconomic Determinants of Breast Reconstruction Outcomes Across Diverse Demographics

Plastic and Reconstructive Surgery, Global Open
Bradley A. Melnick, BS, Abigail J. Uryga, MPAS, Sammer Marzouk, MA, Abbey L. Landini, BA, Tokoya L. Williams, MD, Raiven Harris, BA, Robert D. Galiano, MD   +6 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Pregnancy outcomes after maternal and paternal anti-IL-1 treatment exposure in cryopyrin-associated periodic syndromes (CAPS). [PDF]

Rheumatology (Oxford)
Satirer Ö, Henes J, Henes M, Benseler SM, Kuemmerle-Deschner JB.   +4 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Systematic Review of Adverse Events of IL-1 and IL-6 Inhibitor Use in Pediatrics. [PDF]

J Pediatr Pharmacol Ther
Perera A, Chugh N, Garcia-Bournissen F.
europepmc   +1 more source

74. Comparative Analysis of Acellular Dermal Matrices as Vehicle for Stem Cell Therapy Delivery

Plastic and Reconstructive Surgery, Global Open
Margaret W. Lieb, MD, MS, Calvin A. Korba, MD, Michelle Randle, MS, Carrie E. Harrison, BS, Michael W. Neumeister, MD   +4 more
doaj   +1 more source