Results 181 to 190 of about 1,850,686 (245)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

SP08. Uncovering the Socioeconomic Determinants of Breast Reconstruction Outcomes Across Diverse Demographics

Plastic and Reconstructive Surgery, Global Open
Bradley A. Melnick, BS, Abigail J. Uryga, MPAS, Sammer Marzouk, MA, Abbey L. Landini, BA, Tokoya L. Williams, MD, Raiven Harris, BA, Robert D. Galiano, MD   +6 more
doaj   +1 more source

Activation of the NALP3-CASP1-IL-1 β Inflammatory Pathway by Pesticide Exposure in Human Umbilical Vein Endothelial Cells. [PDF]

Int J Mol Sci
Mazzone A, Della Rocca Y, Flamminii F, Guarnieri S, Bello DG, Nanci A, Trubiani O, Diomede F, Pizzicannella J.   +8 more
europepmc   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Intrinsic immunosuppressive features of monocytes suppress CAR-T19 through IL-1 pathway modulation in mantle cell lymphoma. [PDF]

Mol Ther Oncol
Yun K, Sakemura RL, Can I, Gutierrez Ruiz O, Ogbodo EJ, Zhang S, Saleh A, Huynh TN, Manriquez Roman C, Sirpilla OL, Stewart CM, Girsch JH, Feigin JM, Mai L, Xia H, Kimball B, Kankeu Fonkoua LA, Hefazi M, Ruff MW, Rohakhtar FR, Simon V, Siegler EL, Mattie M, Nguyen-Mau SM, Filosto S, Kenderian SS.   +25 more
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

74. Comparative Analysis of Acellular Dermal Matrices as Vehicle for Stem Cell Therapy Delivery

Plastic and Reconstructive Surgery, Global Open
Margaret W. Lieb, MD, MS, Calvin A. Korba, MD, Michelle Randle, MS, Carrie E. Harrison, BS, Michael W. Neumeister, MD   +4 more
doaj   +1 more source

B cells enhance IL-1 beta driven invasiveness in triple negative breast cancer. [PDF]

Sci Rep
Toney NJ, Opdenaker LM, Frerichs L, Modarai SR, Ma A, Archinal H, Ajayi GO, Sims-Mourtada J.   +7 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

D136. Role of Anterior Scalene Muscle Block in Predicting Outcomes in Rib-sparing Vs. First Rib Resection Techniques For Thoracic Outlet Syndrome

Plastic and Reconstructive Surgery, Global Open
Iulianna Taritsa, BA, Kazimir Bagdady, BS, Rushmin Khazanchi, BA, Cristin Coquillard, MD, Rolando Casas Fuentes, BS, Timothy Burke, BA, Puja Jagasia, BA, Lindsay Janes, MD, Ashley Vavra, MD, Jason H. Ko, MD, MBA, FACS   +9 more
doaj   +1 more source