IL-1 Family Members in Cancer; Two Sides to Every Story
Frontiers in Immunology, 2019 The IL-1 family of cytokines currently comprises of seven ligands with pro-inflammatory activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ) as well as two ligands with anti-inflammatory activity (IL-37, IL-38).
K. Baker, A. Houston, E. Brint
semanticscholar +1 more source
Role of IL-33 in inflammation and disease [PDF]
, 2011 Interleukin (IL)-33 is a new member of the IL-1 superfamily of cytokines that is expressed by mainly stromal cells, such as epithelial and endothelial cells, and its expression is upregulated following pro-inflammatory stimulation.
Miller, Ashley M.
core +3 more sources
A Brief History of IL-1 and IL-1 Ra in Rheumatology [PDF]
Frontiers in Pharmacology, 2017 The history of what, in 1979, was called interleukin-1 (IL-1), orchestrator of leukocyte inter-communication, began many years before then, initially by the observation of fever induction via the endogenous pyrogen (EP) (1974) and then in rheumatology on the role in tissue destruction in rheumatoid diseases via the induction of collagenase and PGE2 in ...
DAYER, JEAN-MICHEL +2 more
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Role of p38 mitogen-activated protein kinase isoforms in murine skin inflammation induced by 12-O-tetradecanoylphorbol 13-acetate [PDF]
, 2011 p38 mitogen-activated protein kinase plays a pivotal role in skin inflammation. The purpose of this study was to investigate the role of the various p38 isoforms. p38 beta/delta-knockout-C57BL/6 mice were generated, studied in a 12-O-tetradecanoylphorbol
Arthur, J. Simon C. +6 more
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IL-1 Family Cytokine Regulation of Vascular Permeability and Angiogenesis
Frontiers in Immunology, 2019 The IL-1 family of cytokines are well-known for their primary role in initiating inflammatory responses both in response to and acting as danger signals.
Erin Fahey, Sarah L. Doyle
semanticscholar +1 more source
Mechanisms of dysregulation of low-density lipoprotein receptor expression in vascular smooth muscle cells by inflammatory cytokines [PDF]
, 2006 Objective - Although inflammation is a recognized feature of atherosclerosis, the impact of inflammation on cellular cholesterol homeostasis is unclear.
Ma, KL +6 more
core +1 more source
ROLE OF IL-1 AND LIPID PEROXIDATION PRODUCTS IN PATHOGENESIS OF ACUTE PANCREATITIS
Медицинская иммунология, 2014 . The review article presents data concerning pathogenetic mechanisms of acute pancreatitis development and poly-organ insufficiency. It was shown IL-1 is among important factors that may determine a severity degree of pancreatitis.
A. N. Plekhanov +2 more
doaj +1 more source
Biomedicines, 2023 Background: it has been suggested that chronic low-grade inflammation plays an important role in the pathogenesis of polycystic ovary syndrome (PCOS).
Elena Vasyukova +8 more
doaj +1 more source
A co-ultramicronized palmitoylethanolamide/luteolin composite mitigates clinical score and disease-relevant molecular markers in a mouse model of experimental autoimmune encephalomyelitis [PDF]
, 2019 Background: Persistent and/or recurrent inflammatory processes are the main factor leading to multiple sclerosis (MS) lesions. The composite ultramicronized palmitoylethanolamide, an endogenous N-acylethanolamine, combined with the flavonoid luteolin ...
Barbierato, M. +5 more
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Type I IL-1 Receptor Mediates IL-1 and Intracellular IL-1 Receptor Antagonist Effects in Skin Inflammation [PDF]
Journal of Investigative Dermatology, 2007 The IL-1 system plays a key role in skin physiology and pathology. In this study, we used mutant mice lacking the type I IL-1 receptor (IL-1RI), lacking IL-1 receptor antagonist (IL-1Ra), or overexpressing the human intracellular (ic) IL-1Ra1 isoform, as well as combinations thereof, to dissect the role of the IL-1 system in phorbol 13-myristate 12 ...
Palmer, Gaby +3 more
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