Results 51 to 60 of about 1,896,687 (246)
Type I IL-1 Receptor Mediates IL-1 and Intracellular IL-1 Receptor Antagonist Effects in Skin Inflammation [PDF]
Journal of Investigative Dermatology, 2007 The IL-1 system plays a key role in skin physiology and pathology. In this study, we used mutant mice lacking the type I IL-1 receptor (IL-1RI), lacking IL-1 receptor antagonist (IL-1Ra), or overexpressing the human intracellular (ic) IL-1Ra1 isoform, as well as combinations thereof, to dissect the role of the IL-1 system in phorbol 13-myristate 12 ...
Palmer G +3 more
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Iatreia, 2010 La sepsis se define como un síndrome de respuesta sistémica en presencia, confirmada o sospechada de infección. Se manifiesta con uno o varios marcadores de enfermedad general, inflamación, anormalidad hemodinámica, disfunción orgánica o falla de ...
Carolina Montoya Ruiz +3 more
doaj
Pediatric Blood &Cancer, EarlyView.ABSTRACT Hemophilic arthropathy remains the leading morbidity in hemophilia despite modern prophylaxis, and early joint damage may be missed by routine exams. This study explored T2* MRI as a noninvasive biomarker of hemosiderin deposition in pediatric hemophilia.
Jessica Garcia +6 more
wiley +1 more source
CYTOKINE GENE POLYMORPHISMS AS PREDICTORS OF CHRONIC PAIN SYNDROME IN ONCOLOGY
Сибирский онкологический журнал, 2017 The literature review on the role of cytokine gene polymorphisms in the development of chronic pain in cancer patients was presented using MedLine, PubMed, NEB elibrary.ru, WileyOnlineLibrary, WebofScience, OxfordUniversityPress and SAGEPremier databases
O. P. Bobrova +4 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Purpose Despite 5‐year survival rates of over 90% among children and adolescents/young adults (CAYAs) with classic Hodgkin lymphoma (cHL), 15%–20% relapse after frontline therapy. Prior analysis of frontline Children's Oncology Group (COG) clinical trials demonstrated that, despite similar rates of relapse, non‐Hispanic Black (NHB) and ...
Mallorie B. Heneghan +14 more
wiley +1 more source
Effects of Hemiscorpius lepturus scorpion venom fractions on cytokine release in male rats [PDF]
مجله علوم پزشکی فیض (پیوسته)Background and Aim: The secretion and activation of cytokines play a significant role in the pathogenesis of scorpion venom. This study aimed to investigate the effects of Hemiscorpius lepturus scorpion venom fractions on the release of IL-1, IL-6, and ...
Daniel Shaebannia +4 more
doaj
Modulation of the IL-1 cytokine network in keratinocytes by intracellular IL-1α and IL-1 receptor antagonist [PDF]
Clinical and Experimental Immunology, 1995 SUMMARYThe IL-1 cytokine network in epidermal cells was studied in vitro, using the spontaneously transformed HaCAT human keratinocyte line. Intracellular (ic) IL-1α and IL-1 receptor antagonist protein (IL-1Ra) following cell lysis were readily identified assayed using a capture ELISA; whereas in culture supernatants IL-1Ra was not detected, and IL-1α
Phillips, W +3 more
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OP0006 Distinct mechanisms of il-1 inhibition revealed by in vitro modelling of il-1 receptor accessory protein interactions with il-1/il-1 receptor complex [PDF]
Annals of the Rheumatic Diseases, 2001 Background IL-1 stimulates cellular responses by interacting with a heterodimeric receptor complex comprised of IL-1 receptor type I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 first binds IL-1RI then IL-1RAcP is recruited to this complex.
BC Varnum, A Witte, C Vezina, X Qian
openaire +1 more source
IL-1 signalling in atherosclerosis [PDF]
Nature Reviews Cardiology, 2019 New research shows that IL-1α and IL-1β have differential effects on atherosclerosis, which is important to consider when selecting anti-inflammatory therapies for patients with cardiovascular disease.
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Impact of Metastatic Patterns on Survival and Response to Therapy in Neuroblastoma
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background While the presence of metastases in neuroblastoma (NB) is a well‐established prognostic factor, the clinical significance of dissemination patterns and tumour burden and their impact on response and survival remains poorly understood.
Mariona Morell‐Daniel +15 more
wiley +1 more source