Results 91 to 100 of about 1,546,418 (287)

IL-13 GENE TRANSLATION IS ARRESTED BY A NOVEL OLIGONUCLEOTIDE IN CULTURED HUMAN B- LYMPHOCYTES

Iranian Journal of Allergy, Asthma and Immunology, 2003
Antisense oligodeoxynucleotides (oligos) are the tools that bind to complemen¬tary sequence of targeted mRNA and block specifically protein translation. In the present study, a novel 20 mer oligo as an antisense for human IL-13 is introduced.
Tahere Mousavi, Bruce Mazer   +1 more
doaj  

Cholesterol-sensing liver X receptors stimulate Th2-driven allergic eosinophilic asthma in mice [PDF]

, 2016
Introduction: Liver X receptors (LXRs) are nuclear receptors that function as cholesterol sensors and regulate cholesterol homeostasis. High cholesterol has been recognized as a risk factor in asthma; however, the mechanism of this linkage is not known.
De Beuckelaer, Ans, Grooten, Johan, Gustafsson, Jan-Ake, Lambrecht, Bart, Naessens, Thomas, Smet, Muriel, Steffensen, Knut R, Van Hoecke, Lien, Vander Beken, Seppe, Vergote, Karl, Willart, Monique   +10 more
core   +1 more source

Pathogenic Germline PALB2 and RAD50 Variants in Patients With Relapsed Ewing Sarcoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Approximately 10% of patients with Ewing sarcoma (EwS) have pathogenic germline variants. Here, we report two cases: first, a novel germline pathogenic variant in partner and localizer of BRCA2 (PALB2) in a patient with a late EwS relapse. Its impact on homologous recombination is demonstrated, and breast cancer risk is discussed.
Molly Mack, A. Carolina Tufino, Mohd Azrin Jamalruddin, Sreya Dey, Yinghong Pan, Elina Mukherjee, Jessica D. Daley, Julia Meade, Mahmoud Aarabi, Lisa Maurer, James Cooper, Kara A. Bernstein, Kelly M. Bailey   +12 more
wiley   +1 more source

Anticancer and bioactivity effect of the AraA-IL13 fusion protein on the glioblastoma cell line

Research in Pharmaceutical Sciences
Background and purpose: Glioblastoma (GBM) is an aggressive and malignant brain cancer with the highest mortality and low survival rates. To discover a more specific and efficient treatment for GBM, we synthesized and examined the cytotoxic effect of ...
Rezvan Mehrab, Hamid Sedighian, Fattah Sotoodehnejadnematalahi, Raheleh Halabian, Abbas Ali Imanifooladi   +4 more
doaj   +1 more source

Improved Outcomes for Older Children, Adolescents, and Young Adults With Neuroblastoma in the Post‐Immunotherapy Era: An Updated Report From the International Neuroblastoma Risk Group

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background We describe clinical and biologic characteristics of neuroblastoma in older children, adolescents, and young adults (OCAYA); describe survival outcomes in the post‐immunotherapy era; and identify if there is an age cut‐off that best discriminates outcomes.
Rebecca J. Deyell, Kavitha Srivatsa, Paola Angelini, Pei‐Chi Kao, Brady Payne, Arlene Naranjo, Sveva Castelli, Miho Kato, Miki Ohira, Ulriche Pöetschger, Yaël Mossé, Lucas Moreno, Meredith S. Irwin, Ramya Ramanujachar, Wendy B. London   +14 more
wiley   +1 more source

Incidence of conjunctivitis adverse event in patients treated with biologics for atopic dermatitis: A systematic review and meta-analysis

JAAD International, 2023
Rose Alraddadi, MD, Abdulrahman H. Alsamadani, MD, Mulham A. Kalantan, MD, Yara E. Aljefri, MD, Hadeel A. Maaddawi, MD, Athoub N. Kadasa, MD, Rahaf F. Alturkistani, MD, Abdulhadi H. Jfri, MD, MSc   +7 more
doaj   +1 more source

Exploring the effects of omega-3 and omega-6 fatty acids on allergy using a HEK-blue cell line.

, 2016
BACKGROUND: Allergic reactions can result in life-threatening situations resulting in high economic costs and morbidity. Therefore, more effective reagents are needed for allergy treatment.
Ahmed, Nayyar, Barrow, Colin, Suphioglu, Cenk   +2 more
core   +2 more sources

T Helper 2 Cytokines Inhibit Autophagic Control of Intracellular Mycobacterium tuberculosis [PDF]

, 2007
SummaryAutophagy is a recently recognized immune effector mechanism against intracellular pathogens. The role of autophagy in innate immunity has been well established, but the extent of its regulation by the adaptive immune response is less well ...
Harris, James, De Haro, Sergio A., Master, Sharon S., Keane, Joseph, Roberts, Esteban A., Delgado, Monica, Deretic, Vojo   +6 more
core   +1 more source

Patient‐Level Barriers and Facilitators to Inpatient Physical Therapy in Adolescents and Young Adults With a Hematological Malignancy: A Qualitative Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Despite their increased risk for functional impairment resulting from cancer and its treatments, few adolescents and young adults (AYAs) with a hematological malignancy receive the recommended or therapeutic dose of exercise per week during inpatient hospitalizations.
Jennifer A. Kelleher, Jennifer L. Bernstein, Katia M. Crisler, Julia K. Herriott, Kimberly L. Klages, Robin E. Norris, Mariann L. Strenk, Sarah E. Bills, Meghan E. McGrady   +8 more
wiley   +1 more source

CD4(+)IL-13(+) cells in peripheral blood well correlates with the severity of atopic dermatitis in children [PDF]

, 2005
In atopic dermatitis (AD) a Th1/Th2 imbalance has been reported, and interleukin (IL)-13 seems to play a pivotal role in the inflammatory network. We tried to assess the correlation between the immunological marker CD4(+)IL-13(+) and the clinical phase ...
CITARRELLA, Roberto, GIORDANO, Carla, LA GRUTTA, Stefania, MATTINA, Antonina, Pajno, G., PASSALACQUA, Girolamo, PIZZOLANTI, Giuseppe, RICHIUSA, Pierina   +7 more
core   +1 more source