Results 101 to 110 of about 1,581,460 (288)

NF-κB signaling and crosstalk during carcinogenesis

4 open, 2019
Transcription factors (TFs) are proteins that control the transcription of genetic information from DNA to mRNA by binding to specific DNA sequences either on their own or with other proteins as a complex.
Brücher Björn L.D.M., Lang Florian, Jamall Ijaz S.   +2 more
doaj   +1 more source

Reduced epithelial suppressor of cytokine signalling 1 in severe eosinophilic asthma [PDF]

, 2016
Severe asthma represents a major unmet clinical need. Eosinophilic inflammation persists in the airways of many patients with uncontrolled asthma, despite high-dose inhaled corticosteroid therapy. Suppressors of cytokine signalling (SOCS) are a family of
Arron, Joseph R, Bradding, Peter, Butler, Claire A, Choy, David F, Doran, Emma, Heaney, Liam G, Johnston, James A, Kissenpfennig, Adrien, O'Rourke, Declan M, Shikotra, Aarti   +9 more
core   +2 more sources

Financial Burden Associated With Hospitalisation Among Families of Childhood Brain Tumours in Australia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Families of children with cancer experience significant financial strain, even with universal healthcare. Indirect costs, such as productivity losses and non‐medical expenses, are rarely included in economic evaluations, and little is known about how effectively financial aid programmes alleviate this burden. Childhood brain tumours
Megumi Lim, Natalie Bradford, David Brain, Sameera Senanayake, Sanjeewa Kularatna, Kate Young, Christine Cashion, Tim Hassall, Susanna Cramb   +8 more
wiley   +1 more source

T Helper 2 Cytokines Inhibit Autophagic Control of Intracellular Mycobacterium tuberculosis [PDF]

, 2007
SummaryAutophagy is a recently recognized immune effector mechanism against intracellular pathogens. The role of autophagy in innate immunity has been well established, but the extent of its regulation by the adaptive immune response is less well ...
Harris, James, De Haro, Sergio A., Master, Sharon S., Keane, Joseph, Roberts, Esteban A., Delgado, Monica, Deretic, Vojo   +6 more
core   +1 more source

The Fate (Outcome) of Clinically Apparent Single Lesion and Oligofocal Nephroblastomatosis Treated According to SIOP/GPOH Protocols for Wilms Tumor

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The management of clinically apparent single lesions or oligofocal nephroblastomatosis, a facultative precursor of nephroblastoma, remains debated. Methods We retrospectively analyzed 37 patients with clinically apparent single or oligofocal nephroblastomatosis (two to three lesions per kidney) among 2347 patients registered between
Nils Welter, Jens‐Peter Schenk, Jenny Wegert, Manfred Gessler, Leo Kager, Stefan Wagenpfeil, Marina Müller, Jean‐Michel Wolff, Joerg Fuchs, Steven W. Warmann, Clemens‐Magnus Meier, Jochen Hubertus, Christian Rübe, Christian Vokuhl, Patrick Melchior, Lena Tschirner, Norbert Graf, Rhoikos Furtwängler   +17 more
wiley   +1 more source

Improvement of Oxazolone-Induced Ulcerative Colitis in Rats Using Andrographolide

Molecules, 2019
Ulcerative colitis (UC) is usually accompanied with symptoms of abdominal pain, diarrhea, and bloody stool, which impair the quality of life of patients.
Liuhong Zhang, Ning Cao, Yuwen Wang, Youxu Wang, Chao Wu, Xuemei Cheng, Changhong Wang   +6 more
doaj   +1 more source

Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis. [PDF]

, 2017
Group 2 innate lymphoid cells (ILC2s) are involved in human diseases, such as allergy, atopic dermatitis and nasal polyposis, but their function in human cancer remains unclear.
Akdis, C.A., Baerlocher, G.M., Basso, G., Bohner, P., Bruni, E., Carlo-Stella, C., Chevalier, M.F., Ciceri, F., Coukos, G., Curti, A., Derré, L., Falvo, P., Gfeller, D., Giarin, E., Girotra, M., Gomez-Cadena, A., Grandclément, C., Jandus, C., Lecciso, M., Leibundgut, E.O., Marcenaro, E., Martinez-Usatorre, A., Mavilio, D., Mazzarella, L., McKenzie, ANJ, Minucci, S., Morita, H., Pallavi, R., Papayannidis, C., Pelicci, P.G., Pizzitola, I., Racle, J., Rambaldi, A., Salomé, B., Salvestrini, V., Santoro, A., Spinelli, O., Taurino, D., Trabanelli, S., Tresoldi, C., Vanhecke, D., Verdeil, G.   +41 more
core   +8 more sources

Inpatient Food Insecurity and Pediatric Hematology Oncology Hospitalization Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Children with cancer and blood disorders are at risk for food insecurity (FI). We aimed to describe the association of inpatient food insecurity (IFI) and hospitalization outcomes among patients admitted to the pediatric hematology oncology service. Of 325 caregivers screened for IFI, 60 (18.6%) screened positive.
Joanna M. Robles, Greg Russell, Leila H. DeWitt, Kimberly Montez, Callie L. Brown   +4 more
wiley   +1 more source

Germline TP53 Mutations Causing Diamond–Blackfan Anemia: A French Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Diamond–Blackfan anemia is a rare congenital erythroblastopenia typically caused by mutations in ribosomal protein genes. Recently, gain‐of‐function mutations in TP53 have been identified as a novel cause of Diamond–Blackfan anemia. We report two French patients who both harbored a heterozygous TP53 deletion (NM_000546.5: c.1077delA; p ...
Rafael Moisan, Lydie Da Costa, Ludivine David Nguyen, Heloise Chosseler, Audrey Riquet, Benedicte Bruno, Melissa Barbati   +6 more
wiley   +1 more source

Genetic Variants in Cytokines IL-10 and IL-17A Are Associated with the Risk and Severity of Sporadic Parkinson’s Disease in Mexican Patients

Life
Background/Objective: Parkinson’s disease (PD) is the most common neurodegenerative movement disorder, in which the inflammatory hypothesis posits that dysregulation of the immune system is an important factor in its etiology.
Nancy Monroy-Jaramillo, Alberto Ortega-Vázquez, Marisol López-López, Laura Virginia Adalid-Peralta   +3 more
doaj   +1 more source