Results 91 to 100 of about 9,970,140 (285)

The role of IL-13 gene polymorphism in the exacerbation of Asthma severity

Sokoto Journal of Medical Laboratory Science, 2023
Asthma is a chronic airway inflammatory disorder characterized by persistent airway inflammation, obstruction, and hyper-responsiveness. The role of cytokines, particularly Interleukin-13 (IL-13), in the pathogenesis of asthma has been extensively ...
Kabir, I.M.1, Ibrahim, S.2, Badamasi, I. M.3, Ibrahim H.S.4, Bala J.A.1, Aliyu I.A1*.
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

IL-4/IL-13 independent goblet cell hyperplasia in experimental helminth infections-0

, 2011
Open bar) and IL-4/IL-13(gray bar) mice 7 days and 10 days PI in small intestine sections. B) Intestinal adult worm burden 7 and 10 days post infection. Data representative of two experiments are shown. Data are means of four mice per group ± SEM.
Lizette CE Fick (58853), Frank Brombacher (52142), Reece G Marillier (58850), William GC Horsnell (58855), Mosiuoa Leeto (58854), Elizabeth M Smith (58852), Chesney Michels (58851), Benjamin Dewals (40167)   +7 more
core   +1 more source

Blockade of IL-33 release and suppression of type 2 innate lymphoid cell responses by helminth secreted products in airway allergy [PDF]

, 2014
Helminth parasites such as the nematode Heligmosomoides polygyrus strongly inhibit T helper type 2 (Th2) allergy, as well as colitis and autoimmunity. Here, we show that the soluble excretory/secretory products of H.
McSorley, H. J.; id_orcid, Smith, K A, Blair, N.F., McSorley, H J, McSorley, H.J., Maizels, R M, McSorley, H. J., Smith, K. A., Smith, K.A., Maizels, R. M., Blair, N F, McKenzie, A.N.J., Blair, N. F., McKenzie, A N J, Maizels, R.M., McKenzie, A. N. J.   +15 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Recent Developments in Monoclonal-Antibody-Based Biologic Therapy for Severe Refractory Eosinophilic Asthma

Antibodies
Background: Asthma exhibits marked heterogeneity both clinically and at the molecular phenotypic level, requiring specifically targeted treatments to block the key pathways of the disease.
Garry M. Walsh
doaj   +1 more source

IL-4/IL-13 independent goblet cell hyperplasia in experimental helminth infections-4

, 2011
Open bar) and IL-4/IL-13(gray bar) mice 7 days and 10 days PI in small intestine sections. B) Intestinal adult worm burden 7 and 10 days post infection. Data representative of two experiments are shown. Data are means of four mice per group ± SEM.
Lizette CE Fick (58853), Frank Brombacher (52142), Reece G Marillier (58850), William GC Horsnell (58855), Mosiuoa Leeto (58854), Elizabeth M Smith (58852), Chesney Michels (58851), Benjamin Dewals (40167)   +7 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The role of IL-13 in the pathogenesis of idiopathic nephrotic syndrome (INS) in children [PDF]

, 2016
Background. INS pathogenesis has been still unclear. Among many factors Th2-derived IL -13 cytokine is taken into account. Objectives. Assessment of serum and urine level of IL -13 in children with INS as a pathogenic factor and a marker of the ...
Agnieszka Pukajło-Marczyk, Danuta Zwolińska   +1 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source