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Effect of IL-13 receptor α2 levels on the biological activity of IL-13 variant R110Q
Journal of Allergy and Clinical Immunology, 2007IL-13 is a key cytokine associated with the asthmatic phenotype. IL-13 signals via its cognate receptor, a complex of IL-13 receptor (IL-13R) alpha 1 chain with IL-4 receptor alpha; however, a second protein, IL-13Ralpha2, also binds IL-13. Recently a polymorphic variant of IL-13 (R110Q) has been shown to be associated with atopy.To investigate the ...
Andrews, Allison-Lynn +6 more
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Role of IL-13 in systemic sclerosis
Cytokine, 2011Systemic sclerosis (SSc) has the highest fatality rate among connective tissue diseases and is characterized by vascular damage, inflammation and fibrosis. Currently, no therapy has proven effective in modifying the course of SSc, a reflection of its complex pathogenesis. T cell-derived cytokines have been implicated in the induction of fibrosis.
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IL-13 in allergy: home at last
Current Opinion in Immunology, 1999The immune response to allergic challenge is thought to include important effects mediated by cytokines. Of considerable interest to immunologists and parasitologists is the distinction between two closely related cytokines, IL-4 and IL-13. Although overlapping functions are inevitable, studies over the past year reveal a distinct role for IL-13 in ...
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Science, 2020
Immunometabolism Interleukin-13 (IL-13) is a cytokine secreted by T cells, innate lymphoid cells (ILC2s), and granulocytes. It acts as a central mediator in allergy and antihelminth defense with various effects. Knudsen et al. report a distinct role for IL-13 in exercise and metabolism (see the Perspective by Correia and Ruas).
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Immunometabolism Interleukin-13 (IL-13) is a cytokine secreted by T cells, innate lymphoid cells (ILC2s), and granulocytes. It acts as a central mediator in allergy and antihelminth defense with various effects. Knudsen et al. report a distinct role for IL-13 in exercise and metabolism (see the Perspective by Correia and Ruas).
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IL-13 and the IL-13 receptor as therapeutic targets for asthma and allergic disease.
Current opinion in investigational drugs (London, England : 2000), 2010It is widely accepted that T-helper 2 cell (Th2) cytokines play an important role in the maintenance of asthma and allergy. Emerging evidence has highlighted the role of IL-13 in the pathogenesis of these diseases. In particular, IL-13 is involved in the regulation of IgE synthesis, mucus hypersecretion, subepithelial fibrosis and eosinophil ...
Jesse, Mitchell +2 more
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1995
Abstract The mouse IL-13 cDNA (GenBank accession number M23504) encodes a protein of 131 amino acids (Brown eta/. 1989). The human IL-13 (hlL-13) cDNA (GenBank accession No L06801) encodes a protein of 132 amino acids (McKenzie et al. 1993a; Minty eta/. 1993).
A N J McKenzie, G Zurawski
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Abstract The mouse IL-13 cDNA (GenBank accession number M23504) encodes a protein of 131 amino acids (Brown eta/. 1989). The human IL-13 (hlL-13) cDNA (GenBank accession No L06801) encodes a protein of 132 amino acids (McKenzie et al. 1993a; Minty eta/. 1993).
A N J McKenzie, G Zurawski
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IL-13 and Double IL-4/IL-13 Knockout Mice
2003Duncan R. Hewett, Andrew N. J. McKenzie
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