IL-13 decreases susceptibility to airway epithelial SARS-CoV-2 infection but increases disease severity in vivo via eicosanoid signalling. [PDF]
EBioMedicineGhimire S +12 more
europepmc +1 more source
Validation of <i>S100A16</i> as an asthma biomarker and its role in IL-13-induced bronchial epithelial cell injury. [PDF]
J Thorac DisZhang H +10 more
europepmc +1 more source
Differential regulation of 5-lipoxygenase and leukotriene-C4-synthase expression by IFNγ, IL-4 and IL-13 in human monocytes and macrophages from patients with atopic dermatitis. [PDF]
Inflamm ResLietzau S +4 more
europepmc +1 more source
IL-13 inhibition in the treatment of atopic dermatitis - new and emerging biologic agents. [PDF]
J Int Med ResTeixeira C +3 more
europepmc +1 more source
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Opposing roles for IL‐13 and IL‐13 receptor α2 in health and disease
Immunological Reviews, 2004Summary: Interleukin (IL)‐13 is a key inducer of several type‐2 cytokine‐dependent pathologies. It regulates inflammation, mucus production, tissue remodeling, and fibrosis. Consequently, it has become an important therapeutic target for a number of debilitating illnesses, including asthma, idiopathic pulmonary fibrosis, ulcerative colitis, as well as
Margaret M, Mentink-Kane, Thomas A, Wynn
openaire +2 more sources
Asthma markedly diminishes quality of life due to limited activity, absences from work or school and hospitalizations. Patients with severe asthma which are not controlled despite taking effective therapy are most in need of new treatment approaches.
Swati, Agrawal, Robert G, Townley
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Polymorphisms of IL–13 and IL–4–IL–13–SNPs in patients with penicillins allergy
European Journal of Clinical Pharmacology, 2005Although IL-4 and IL-13 share many biologic activities, some are unique to IL-13. We genotype the IL-13 and IL-4-IL-13-SNPs genes for polymorphisms that could then be used to determine associations with IgE regulation as well as levels of IL-4 and IL-13.Eight kinds of IgE specific to penicillins were determined with radioallergosorbent test (RAST) in ...
Jing, Yang +2 more
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Genetics of IL-13 and functional relevance of IL-13 variants
Current Opinion in Allergy and Clinical Immunology, 2002Studies in both humans and mice clearly show that interleukin (IL)-13 is a central regulator of allergic inflammation. Numerous single nucleotide polymorphisms have been recently identified in the IL-13 gene and have been found to be associated with allergic and/or asthmatic phenotypes in different populations throughout the world.
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Effect of IL-13 receptor α2 levels on the biological activity of IL-13 variant R110Q
Journal of Allergy and Clinical Immunology, 2007IL-13 is a key cytokine associated with the asthmatic phenotype. IL-13 signals via its cognate receptor, a complex of IL-13 receptor (IL-13R) alpha 1 chain with IL-4 receptor alpha; however, a second protein, IL-13Ralpha2, also binds IL-13. Recently a polymorphic variant of IL-13 (R110Q) has been shown to be associated with atopy.To investigate the ...
Andrews, Allison-Lynn +6 more
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IL-13 was first recognized for its effects on B cells and monocytes, where it upregulated class II expression, promoted IgE class switching and inhibited inflammatory cytokine production. It was also thought to be functionally redundant with IL-4. However, studies conducted with knockout mice, neutralizing antibodies, and novel antagonists demonstrate ...
openaire +2 more sources