Results 91 to 100 of about 5,540,448 (336)

Functional variation among LPMOs revealed by the inhibitory effects of cyanide and buffer ions

FEBS Letters, Volume 599, Issue 9, Page 1317-1336, May 2025.
This study addresses the inhibition of lytic polysaccharide monooxygenases (LPMOs) by cyanide and explains how and why the magnitude of observed inhibitory effects depends on the way LPMO reactions are setup and on the type of LPMO. Enzymes known as lytic polysaccharide monooxygenases (LPMOs) are mono‐copper polysaccharide‐degrading peroxygenases that ...
Ole Golten, Lorenz Schwaiger, Zarah Forsberg, Kelsi R. Hall, Anton A. Stepnov, Tom Z. Emrich‐Mills, Iván Ayuso‐Fernández, Morten Sørlie, Roland Ludwig, Åsmund Kjendseth Røhr, Vincent G. H. Eijsink   +10 more
wiley   +1 more source

Positive and Negative Regulation of Th17 Cell Differentiation: Evaluating The Impact of RORC2 [PDF]

Cell Journal, 2014
Objective: Th17 cells are known to be involved in some types of inflammations and autoimmune disorders. RORC2 is the key transcription factor coordinating Th17 cell differentiation.
Mazdak Ganjalikhani Hakemi, Kamran Ghaedi, Vida Homayouni, Alireza Andalib, Mohsen Hosseini, Abbas Rezaei   +5 more
doaj  

IL-17 Activates the IL-6/STAT3 Signal Pathway in the Proliferation of Hepatitis B Virus-Related Hepatocellular Carcinoma

Cellular Physiology and Biochemistry, 2017
Background/Aims: We performed this study to determine the role of IL-17 in the immune microenvironment of hepatitis B virus- (HBV-) related hepatocellular carcinoma (HCC).
Zongqiang Hu, Ding Luo, Dongdong Wang, Linjie Ma, Yingpeng Zhao, Li Li   +5 more
doaj   +1 more source

Metabolic abnormalities exacerbate Sjögren’s syndrome by and is associated with increased the population of interleukin–17–producing cells in NOD/ShiLtJ mice

Journal of Translational Medicine, 2020
Background Sjögren’s syndrome (SS) is an autoimmune disease mediated by lymphocytic infiltration into exocrine glands, resulting in progressive lacrimal and salivary destruction and dysfunctional glandular secretion.
Sun-Hee Hwang, Jin-Sil Park, SeungCheon Yang, Kyung-Ah Jung, JeongWon Choi, Seung-Ki Kwok, Sung-Hwan Park, Mi-La Cho   +7 more
doaj   +1 more source

IL-17's tumor team

Journal of Experimental Medicine, 2009
In cancer, tumors may skew a cytokine tug-of-war to favor their own growth and survival, according to Wang et al. on [page 1457][1]. ![Figure][2] Without IL-17, STAT3 levels drop, slowing tumor growth and spread (arrows).
openaire   +3 more sources

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

FEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung, Mikhail G. Dozmorov, SuJeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae   +6 more
wiley   +1 more source

IL‐23R Deficiency Does Not Impact Atherosclerotic Plaque Development in Mice

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundInterleukin‐23 (IL‐23) has been implicated in inflammatory and autoimmune diseases by skewing CD4+ T helper cells towards a pathogenic Th17 phenotype. In this study we investigated the presence of IL‐23 receptor (IL‐23R)‐expressing cells in the
Daniel Engelbertsen, Marie A. C. Depuydt, Robin A. F. Verwilligen, Sara Rattik, Erik Levinsohn, Andreas Edsfeldt, Felicia Kuperwaser, Petr Jarolim, Andrew H. Lichtman   +8 more
doaj   +1 more source

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

FEBS Letters, Volume 599, Issue 8, Page 1094-1112, April 2025.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher, Paula Armina V. Buco, Jia Q. Truong, Paul A. Ramsland, Monique F. Smeets, Carl R. Walkley, Jessica K. Holien   +6 more
wiley   +1 more source

Structural and mechanistic basis for the regulation of the chloroplast signal recognition particle by (p)ppGpp

FEBS Letters, EarlyView.
LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra, Paul Weiland, Pauline Anka Plitzko, Julia Thiery, Laura Czech, Felix Willmund, Patricia Bedrunka, Gert Bange   +7 more
wiley   +1 more source

IL-17 inhibits CXCL9/10-mediated recruitment of CD8+ cytotoxic T cells and regulatory T cells to colorectal tumors

Journal of Immunotherapy for Cancer, 2019
BackgroundThe IL-17 family cytokines are potent drivers of colorectal cancer (CRC) development. We and others have shown that IL-17 mainly signals to tumor cells to promote CRC, but the underlying mechanism remains unclear.
Ju Chen, Xiaoyang Ye, Elise Pitmon, Menglong Lu, J. Wan, Evan R. Jellison, A. Adler, A. Vella, Kepeng Wang   +8 more
semanticscholar   +1 more source