Results 181 to 190 of about 6,990,253 (295)
, 2011 スギ花粉症患者の遺伝子多型による解析からORMDL3、DAF において数ヵ所にリス クアレルが存在することが判明した。ORMDL3 リスクアレル患者では、CD4 陽性細胞におけるpoly-IC 刺 激でのIL-17 産生と肥満細胞からのスフィンゴシン1 リン酸脱顆粒が高いことが判明した。DAF は、補 体C3 が活性化してC3a(アナフィラトキシン)になるのを抑制するが、スギ花粉症患者では、スギ飛散 期に健常人に比べDAF のmRNA 発現が有意に低下していた。さらに同時期スギ花粉症患者の網羅的蛋白 ...
藤枝, 重治 +4 more
core
Context-specific roles for IL-17 in tuberculosis. [PDF]
PLoS PathogMaseeme M +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Association of IL-6 and IL-17 with thyroid eye disease. [PDF]
Front Endocrinol (Lausanne)Sun X, Jiang Y, Liu Z, Zhao L.
europepmc +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Un colpo di pistola nel concerto. Il dibattito su politica e letteratura tra il '17 e il '68
, 2016 Il libro, attraverso una serie di saggi, intende ripercorrere i punti salienti del dibattito sulla politicità della letteratura, mostrando come il rapporto sia sempre stato complesso e particolarmente nei momenti di politica radicale e di letteratura ...
MUZZIOLI, Francesco
core
Could the IL-17 cytokine family be a promising target for the treatment of palmoplantar pustulosis? [PDF]
J Eur Acad Dermatol VenereolMrowietz U, Gerdes S.
europepmc +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Hidradenitis Suppurativa and IL-17 Inhibitors: A Focus on Trials and Real-Life Data. [PDF]
Medicina (Kaunas)Martora F +4 more
europepmc +1 more source