Results 191 to 200 of about 67,041,806 (280)

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Comparative Effects of IL-17 and IL-23 Inhibitors on Lipid Profiles and Lipid-Derived Atherogenic Indices in Patients with Psoriasis. [PDF]

Pharmaceuticals (Basel)
Celik C, Çelik MS, Cepik N.
europepmc   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Cutaneous Adverse Reactions to IL-17 and IL-23 Inhibitors: A Clinical Review of Reaction Patterns. [PDF]

Dermatol Pract Concept
Park I, Bayrouti A, MacIntyre D, Le V, Nguyen KB.   +4 more
europepmc   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

NMI promotes the secretion of IL-17 and exacerbates psoriasis. [PDF]

Proc Natl Acad Sci U S A
Gao Y, Wang J, Qin Z, Xu N, Wang X, Liu T, Wang S, Chen Z, Xu Y, Yao Y, Wu Y, Weng Z, Geng Y, Yin Z, Qin J, Xu T, Liu Y, Liang H.   +17 more
europepmc   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

XuanBi Mitigates Rheumatoid Arthritis via Regulation of ECM-Receptor Interactions and IL-17 Signaling: Insights From Integrated Proteomic and Pharmacological Analyses. [PDF]

Food Sci Nutr
Zhu H, Pan Z, Lu Y, Xia P, He W, Zeng J, Wang F, Liu X, Wei M.   +8 more
europepmc   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

An IL-17-DUOX2 axis controls gastrointestinal colonization by Candida albicans. [PDF]

Nat Commun
Kakade P, Burgueno JF, Sircaik S, Ponde NO, Li J, Ene IV, Kim J, Liang SH, Yunker R, Dey I, Akiba Y, Vaishnava S, Kaunitz JD, Way SS, Koh AY, Gaffen SL, Abreu MT, Bennett RJ.   +17 more
europepmc   +1 more source