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IL-17 targeted therapies for psoriasis
Expert Opinion on Investigational Drugs, 2013Psoriasis is a chronic, disabling, inflammatory skin disease whose pathogenesis still remains to be fully elucidated. Genetic and environmental factors induce an immune response mediated by several cytokines and chemokines, including IL-17A.Emerging evidence now suggests that IL-17A is central in the pathogenesis of psoriasis. Three agents neutralizing
CHIRICOZZI, ANDREA, Krueger J.G.
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IL-17 instructs lymphoid stromal cells
Nature Immunology, 2019The cytokine IL-17 augments metabolism in fibroblastic reticular cells in lymph nodes, which enhances their proliferation and survival to support B cell responses during autoimmunity.
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