Results 221 to 230 of about 1,534,063 (244)
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Journal of Allergy and Clinical Immunology, 2004
A new family of cytokines, IL-17, has recently been defined that reveals a distinct ligand-receptor signaling system. Functional studies have provided evidence for its importance in the regulation of immune responses. Notably, 3 members, IL-17A, IL-17E (IL-25), and IL-17F, have been best characterized both in vitro and in vivo , and have been shown to ...
Mio, Kawaguchi +4 more
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A new family of cytokines, IL-17, has recently been defined that reveals a distinct ligand-receptor signaling system. Functional studies have provided evidence for its importance in the regulation of immune responses. Notably, 3 members, IL-17A, IL-17E (IL-25), and IL-17F, have been best characterized both in vitro and in vivo , and have been shown to ...
Mio, Kawaguchi +4 more
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The Impact of IL-17 in Atherosclerosis
Current Medicinal Chemistry, 2017Atherosclerosis is a chronic vascular disease in which atherosclerotic plaques develop in the arterial wall. It is believed that inflammation plays a major role in atherosclerotic formation and progression. Thus, atherosclerosis can be considered as an inflammatory disease of the arterial vessel.
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Expression and clinical significance of IL-17 and IL-17 receptor in ulcerative colitis
Journal of Huazhong University of Science and Technology [Medical Sciences], 2016The purpose of this study was to determine the expression levels of IL-17 in serum and IL-17 receptor (IL-17R) in intestinal mucosa tissue in patients with ulcerative colitis (UC) and controls, and evaluate their relationship with disease activity and explore the role of IL-17 in the patho-genesis of UC. A total of 36 Chinese UC patients and 60 healthy
Heng, Zhang +6 more
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2006
IL-17A and its receptor are the founding members of a recently described cytokine family, with unique sequences and functions in the immune system and elsewhere. Consisting of six ligands (IL-17A-F) and five receptors (IL-17RA-IL-17RE) in mammals, these molecules have distinct primary amino acid structures with only minimal homology to other cytokine ...
Sarah L, Gaffen +3 more
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IL-17A and its receptor are the founding members of a recently described cytokine family, with unique sequences and functions in the immune system and elsewhere. Consisting of six ligands (IL-17A-F) and five receptors (IL-17RA-IL-17RE) in mammals, these molecules have distinct primary amino acid structures with only minimal homology to other cytokine ...
Sarah L, Gaffen +3 more
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IL-17/IL-17 receptor system in autoimmune disease: mechanisms and therapeutic potential
Clinical Science, 2012IL-17 (interleukin-17), a hallmark cytokine of Th17 (T-helper 17) cells, plays critical roles in host defence against bacterial and fungal infections, as well as in the pathogenesis of autoimmune diseases. The present review focuses on current knowledge of the regulation, functional mechanisms and targeting strategies of IL-17 in the context of ...
Shu, Zhu, Youcun, Qian
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The role of IL-17 and IL-17 receptor inhibitors in the management of generalized pustular psoriasis
Drugs of Today, 2019Generalized pustular psoriasis (GPP) is a severe psoriasis form that can be refractory to several systemic treatments. The role of interleukin (IL)-17/ T-helper 17 (Th17) axis inhibitors in the therapy of GPP is not fully established. The objective of this paper is to summarize the existing information on the efficacy and safety of secukinumab ...
K- M, Plachouri +2 more
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Role of IL-17 and IL-17 Family Cytokines on Tumor Development
2012Anticancer immune responses restrain tumor progression, but persistent immune activation can induce chronic inflammation that contributes to tumor development. The IL-17 family of cytokines comprises six family members (IL-17A to IL-17F) that all contribute to tissue inflammation.
Frédérique Végran +2 more
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