Results 291 to 300 of about 5,540,448 (336)

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

Human MAIT cell response profiles biased toward IL-17 or IL-10 are distinct effector states directed by the cytokine milieu. [PDF]

Proc Natl Acad Sci U S A
Boulouis C, Mouchtaridi E, Müller TR, Mak JYW, Fairlie DP, Bergman P, Michaëlsson J, Halfvarson J, Mjösberg J, Buggert M, Sandberg JK.   +10 more
europepmc   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Distinct therapeutic effects of auraptene and umbelliprenin on TNF-α and IL-17 levels in a murine model of chronic inflammation. [PDF]

Heliyon
Joveini S, Yarmohammadi F, Iranshahi M, Nikpoor AR, Askari VR, Attaranzadeh A, Etemad L, Taherzadeh Z.   +7 more
europepmc   +1 more source

The role of IL-17 in the pathogenesis and treatment of glioblastoma-an update on the state of the art and future perspectives. [PDF]

Med Oncol
Łaszczych D, Czernicka A, Gostomczyk K, Szylberg Ł, Borowczak J.   +4 more
europepmc   +1 more source

Expression Levels of lncRNA NEAT1, miRNA-21, and IL-17 in a Group of Egyptian Patients with Behçet's Disease: Relation to Disease Manifestations and Activity. [PDF]

Biologics
Hussein WH, Ramadan H, Labib S, Hegazy GA, Shaker OG, Yusuf SM, Hassanien MA, Haroon MM.   +7 more
europepmc   +1 more source

IL-17: a novel player in the pathogenesis of vulvar lichen sclerosus. [PDF]

Postepy Dermatol Alergol
Baran W, Woźniak Z, Batycka-Baran A.
europepmc   +1 more source

IL-17 signaling in primary sclerosing cholangitis patient-derived organoids. [PDF]

Hepatol Commun
Garcia Moreno AS, Guicciardi ME, Wixom AQ, Jessen E, Yang J, Ilyas SI, Bianchi JK, Pinto E Vairo F, Lazaridis KN, Lazaridis KN, Gores GJ, Gores GJ.   +11 more
europepmc   +1 more source

SPHK2 Knockdown Inhibits the Proliferation and Migration of Fibroblast-Like Synoviocytes Through the IL-17 Signaling Pathway in Osteoarthritis. [PDF]

J Inflamm Res
Zheng J, Xiong X, Li K, Wang G, Cao H, Huang H.   +5 more
europepmc   +1 more source