Results 301 to 310 of about 5,540,448 (336)
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Annual Review of Immunology, 2009
CD4+ T cells, upon activation and expansion, develop into different T helper cell subsets with different cytokine profiles and distinct effector functions.
T. Korn +3 more
semanticscholar +4 more sources
CD4+ T cells, upon activation and expansion, develop into different T helper cell subsets with different cytokine profiles and distinct effector functions.
T. Korn +3 more
semanticscholar +4 more sources
IL-17 controls central nervous system autoimmunity through the intestinal microbiome
Science immunology, 2021IL-17 is a key safeguard of intestinal homeostasis, indirectly modulating the autoimmune response against CNS antigens. Gut reaction to IL-17 Whether IL-17A/F or TH17 cells are necessary for the immunopathogenesis of human multiple sclerosis (MS) has ...
Tommy Regen +25 more
semanticscholar +1 more source
Journal of Dermatological Science, 2017
The cytokine IL-17 is now a target for an array of therapeutic monoclonal antibodies supposed to treat a variety of inflammatory diseases. The forerunner Secukinumab, an IL-17A neutralizing antibody, is meanwhile approved as first-line treatments for moderate-to-severe plaque psoriasis, and as second-line treatment for psoriatic arthritis and ...
Florian C. Kurschus, Sonja Moos
openaire +3 more sources
The cytokine IL-17 is now a target for an array of therapeutic monoclonal antibodies supposed to treat a variety of inflammatory diseases. The forerunner Secukinumab, an IL-17A neutralizing antibody, is meanwhile approved as first-line treatments for moderate-to-severe plaque psoriasis, and as second-line treatment for psoriatic arthritis and ...
Florian C. Kurschus, Sonja Moos
openaire +3 more sources
Expert Review of Respiratory Medicine, 2012
Asthma is perceived as a heterogeneous disease with several clinical phenotypes and triggering factors. In general, cytokines from T-helper 2 cells are believed to be critical contributors of asthma. In recent years, IL-17, another T-helper lymphocyte-associated cytokine, has been put forward as another potentially important mediator of asthma ...
Elin Silverpil, Anders Lindén
openaire +2 more sources
Asthma is perceived as a heterogeneous disease with several clinical phenotypes and triggering factors. In general, cytokines from T-helper 2 cells are believed to be critical contributors of asthma. In recent years, IL-17, another T-helper lymphocyte-associated cytokine, has been put forward as another potentially important mediator of asthma ...
Elin Silverpil, Anders Lindén
openaire +2 more sources
IL-17 family cytokines and the expanding diversity of effector T cell lineages.
Annual Review of Immunology, 2007Since its conception two decades ago, the Th1-Th2 paradigm has provided a framework for understanding T cell biology and the interplay of innate and adaptive immunity.
C. Weaver +3 more
semanticscholar +1 more source
Expert Review of Clinical Immunology, 2019
Introduction: Psoriasis is a chronic, immune-mediated disease with significant associated comorbidities. Its pathogenesis is likely multifactorial, however, the interleukin-23/T helper 17 pathway has been identified as a critical axis in its pathogenesis.
Karen Ly +5 more
openaire +3 more sources
Introduction: Psoriasis is a chronic, immune-mediated disease with significant associated comorbidities. Its pathogenesis is likely multifactorial, however, the interleukin-23/T helper 17 pathway has been identified as a critical axis in its pathogenesis.
Karen Ly +5 more
openaire +3 more sources
Expression and clinical significance of IL-17 and IL-17 receptor in ulcerative colitis
Journal of Huazhong University of Science and Technology [Medical Sciences], 2016The purpose of this study was to determine the expression levels of IL-17 in serum and IL-17 receptor (IL-17R) in intestinal mucosa tissue in patients with ulcerative colitis (UC) and controls, and evaluate their relationship with disease activity and explore the role of IL-17 in the patho-genesis of UC. A total of 36 Chinese UC patients and 60 healthy
Heng Zhang +6 more
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Nature Reviews Immunology, 2019
IL-17-producing γδ T cells in the meningeal spaces support short-term spatial memory formation.
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IL-17-producing γδ T cells in the meningeal spaces support short-term spatial memory formation.
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IL-17 targeted therapies for psoriasis
Expert Opinion on Investigational Drugs, 2013Psoriasis is a chronic, disabling, inflammatory skin disease whose pathogenesis still remains to be fully elucidated. Genetic and environmental factors induce an immune response mediated by several cytokines and chemokines, including IL-17A.Emerging evidence now suggests that IL-17A is central in the pathogenesis of psoriasis. Three agents neutralizing
CHIRICOZZI, ANDREA, Krueger J.G.
openaire +4 more sources