Results 141 to 150 of about 1,536,578 (286)
EngThis paper discusses a methodology to improve the prevention processes of chronic diseases such as diabetes and strokes. The research motivation is to find a new methodological approach to design advanced Diagnostic and Therapeutic Care Pathways (PDTAs ...
Angelo Rosa, Alessandro Massaro
doaj +1 more source
Pengaruh Konseling Modifikasi Gaya Hidup terhadap Asupan Lemak, Kadar Trigliserida dan Interleukin(IL)-18 pada Remaja Obesitas dengan Sindrom Metabolik [PDF]
, 2016 Latar Belakang: Sindrom metabolik merupakan kumpulan dari berbagai kelainan metabolik seperti resistensi insulin, obesitas sentral, hipertensi, dislipidemi, keadaan proinflamasi dan protrombik.
Indaryono, Cleo Syahana +1 more
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Investigation of Interleukin -18 Gene Polymorphisms and Serum Level in Patients with Preeclampsia
Armaghane Danesh Bimonthly Journal, 2011 Background & Aim: Preeclampsia is one of the most important factors in fetal and maternal mortality that seems to change immunological parameters such as rate of auto antibodies and cytokines involved in the disease.
M Solimanipour, S Naeimi, N Erfani
doaj
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2018 目的探讨NLRP3炎症小体、白细胞介素-18(IL-18)和白细胞介素-1β(IL-1β)与牙周炎的关系。方法选取2016年2月至2017年2月在我院治疗的慢性牙周炎患者58例为病例组,选取同期健康志愿者60例作为对照组,采用酶联免疫吸附试验(ELISA)法检测血清和龈沟液IL-18和IL-1β,采用RT-PCR检测血清NLRP3mRNA表达。结果病例组血清NLRP3mRNA相对表达量、IL-18和IL-1β分别为(1.472±0.331)、(57.93±15.49)pg/ml和(34.29±8.99 ...
赵西珍, 张松涛, 高黎
doaj
Inhibitory Effects of Ethanol on the NLRP3 Inflammasome [PDF]
, 2015 Immunosuppression is a major complication of alcoholism and contributes to increased rates of opportunistic infections and sepsis associated with the addiction.
Hoyt, Laura Rose
core +1 more source