Results 141 to 150 of about 1,564,564 (287)
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Niveles de citocinas pro Th1 en orina de pacientes con lupus eritematoso sistémico [PDF]
, 2013 72 Páginas.Los estudios han sugerido que hay un imbalance en la producción de células T helper, (Th1 y Th2) que juega un papel importante en la patogénesis del LES. Además, se ha demostrado el predominio de genes de expresión de las citocinas Th1 y MCP-1
Rosero Revelo, Ricardo Javier +1 more
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Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
EngThis paper discusses a methodology to improve the prevention processes of chronic diseases such as diabetes and strokes. The research motivation is to find a new methodological approach to design advanced Diagnostic and Therapeutic Care Pathways (PDTAs ...
Angelo Rosa, Alessandro Massaro
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Investigation of Interleukin -18 Gene Polymorphisms and Serum Level in Patients with Preeclampsia
Armaghane Danesh Bimonthly Journal, 2011 Background & Aim: Preeclampsia is one of the most important factors in fetal and maternal mortality that seems to change immunological parameters such as rate of auto antibodies and cytokines involved in the disease.
M Solimanipour, S Naeimi, N Erfani
doaj
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
AMPK Phosphorylation Modulates Pain by Activation of NLRP3 Inflammasome [PDF]
, 2016 Impairment in adenosine monophosphate-activated protein kinase (AMPK) activity and NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation are associated with several metabolic and inflammatory diseases.
Alcocer-Gómez, Elísabet +5 more
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