Results 151 to 160 of about 70,619,624 (286)

Targeting Interleukin-18 (IL-18) in malaria infection

, 2009
The potential of IL-18 as drug target during malaria infection was investigated in an experimental model. IL-18 production during the infection was modulated with IL-18 related drugs and the effects on the course of infection and the release of pro- and ...
Gam, Lay Harn, Mahmud, Roziahanim, Ismail, Sabariah, Basir, Rusliza, Kartini, Hasballah, Abdul Majid, Amin Malik   +5 more
core   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Association between IL-18/18R gene polymorphisms and coronary artery disease: influence of IL-18/18R genetic variants on cytokine expression

, 2018
Vadim Mitrokhin,1 Alexey Nikitin,2 Olga Brovkina,2 Dmitry Khodyrev,2 Alexander Zotov,2 Nikita Vachrushev,1 Dmitry Dragunov,3 Andrey Shim,1 Mitko Mladenov,1,4 Andre Kamkin1 1Department of Fundamental and Applied Physiology, Russian National Research ...
Dragunov D, Kamkin A, Nikitin A, Khodyrev D, Vakhrushev N, Zotov A, Shim A, Mitrokhin V, Brovkina O, Mladenov M   +9 more
core  

Editorial: IL-1 Family Members in Health and Disease

Frontiers in Immunology, 2019
Elizabeth Brint, Elizabeth Brint, Thomas Kamradt, Sarah L. Doyle, Sarah L. Doyle   +4 more
doaj   +1 more source

IL-18 in atherosclerosis: context-dependent biology, human evidence, and translational challenges. [PDF]

Front Cardiovasc Med
Zhang D, Wang S, Li Y, Zhang H, Wang B.
europepmc   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Microglia-targeted delivery of MCC950 suppresses NLRP3-IL-18-mediated neuroinflammation and retinal injury in retinal vein occlusion. [PDF]

Bioact Mater
Xue X, Jiang H, Zhang W, Zhou Y, Li H, Zhou C, Chen Y, Ma W, Gao Y, Ji X, Zhou C, Zhang X.   +11 more
europepmc   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Associations of the inflammasome-dependent cytokine IL-18 with risk of coronary heart disease. [PDF]

Cardiovasc Res
Björkbacka H, Gonçalves I, Engström G, Schiopu A, von Sydow A, Ryaboshapkina M, Varma V, Moss A, Shore AC, Natali A, Khan F, Nilsson J.   +11 more
europepmc   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source