Results 171 to 180 of about 7,408,636 (290)

IL-18 suppresses retinoblastoma growth while concomitantly inducing an inflammation-/stress-associated and immune-remodeling response. [PDF]

Cancer Cell Int
Chen Z, Luo W, Wei D, Wang Q, Gou Q, Cao J, Mai Q, Chen X, Cai X, Chen X, Zhang J.   +10 more
europepmc   +1 more source

IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome.

Cell Metabolism, 2016
A. Murphy, M. Kraakman, H. Kammoun, D. Dragoljevic, Man Kit Sam Lee, K. Lawlor, J. Wentworth, Ajithkumar Vasanthakumar, M. Gerlic, L. Whitehead, Ladina DiRago, Louise H. Cengia, Rachael M. Lane, D. Metcalf, J. Vince, L. Harrison, A. Kallies, B. Kile, B. Croker, M. Febbraio, S. Masters   +20 more
semanticscholar   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

IL-18-armed oncolytic vaccinia virus remodels the suppressive microenvironment via macrophage and Treg modulation in lymphoma. [PDF]

Cancer Immunol Immunother
Wu H, Zhang J, Xu L, Xie Y, Pan L, Zhang X, Xia Y, Yang F, Kang X, Tong X, Wang S.   +10 more
europepmc   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

IL-18 and MIG increase one year after transition to dolutegravir-based dual therapy despite sustained viral suppression. [PDF]

Front Immunol
Pérez-González A, Alonso-Domínguez J, Martínez-Barros I, López-López A, Labajo-Leal L, Ocampo A, Poveda E.   +6 more
europepmc   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Epithelial NLRP3 drives silica-induced lung injury and fibrosis through IL-18 and pro-fibrotic neutrophil recruitment. [PDF]

Part Fibre Toxicol
Lam M, Barry KT, Hodges CJ, West AC, Harpur CM, Mansell A, Tate MD.   +6 more
europepmc   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Intestinal resident effector-memory CD4 T cells on the adaptive-innate spectrum comprise IL-18 reactivity and adaptive CMV specificity. [PDF]

Sci Adv
Kammann T, Voigt I, Wild N, Kokkinou E, Cai C, Sekine T, Nilsén V, Weigel W, Tibbitt C, Stamper C, Marchalot A, Bassett J, Kaushal J, Ferreira S, Mouchtaridi E, Raineri EJM, Müller TR, Ballesteros OR, Gao Y, Mily A, Adamo S, Constantz C, Rødahl I, Brownlie D, Michaelsson J, Mjösberg J, Birk M, Buggert M, Marquardt N, Jorns C, Sandberg JK.   +30 more
europepmc   +1 more source