Results 131 to 140 of about 15,868,375 (334)
Anti-tumor effect of tumor specific replicating adenovirus expressing IL-12 and IL-18
, 2006 의과학과/석사[한글]암에 대한 면역 치료법은 부작용이 심각한 기존의 방사선 요법 , 항암화학 요법과는 달리 우리 몸의 면역 체계를 활성화시킴으로서 암 세포만을 특이적으로 제거하는데 그 목적이 있다. 하지만, 암 세포들은 여러 가지 전략을 사용하여 면역 체계를 교묘히 피해가며, 설사 면역 체계가 활성화 되었더라도 활성화된 항종양 면역 반응으로부터 도피할 수 있는 능력 또한 갖고 있기 때문에 항암 면역 치료에 많은 한계를 드러내고 있다. 따라서 이와 같이
최일규
core
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Olaparib attenuates the oxLDL-mediated increase in pro-IL-1β and pro-IL-18 protein expression.
THP-1 monocytes were exposed to oxLDL, the PARP inhibitor olaparib (Olapa), or the NLRP3 inhibitor MCC950 (MCC), individually or in combination as indicated. Cell lysates were subjected to SDS-PAGE and immunoblotted with anti-pro-IL-1β (top), anti-pro-IL-
Hewang Lee (13839931) +9 more
core +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
, 2011 Il capitolo presenta i risultati di un questionario rivolto agli intermediari bancari italiani che operano nel comparto del microcredito finalizzato ad indagare lo stato dell'arte di questo business (margini prodotti, modalità di valutazione del rischio,
PORRETTA, Pasqualina
core
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
IL-18 increases paracellular permeability when applied to the apical surface.
, 2018 HT-29 cells were grown in monolayers in Transwell chambers. When confluent, IL-18 (10 ng /ml), IL-1β (10 ng/ml) or Tat (100 ng/ml) were applied to the apical surface (A) or to the Transwell bottom wells (B).
Vikram Mehraj (376026) +7 more
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Frontiers in Oral HealthObjectiveTo evaluate the combined effects of azithromycin and varying concentrations of cyclosporin on peripheral blood mononuclear cells (PBMCs) under lipopolysaccharide (LPS) stimulation.Materials and methodsPBMCs were isolated from four healthy donors
Norah Alotaibi +7 more
doaj +1 more source