Results 111 to 120 of about 70,619,624 (286)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Agree to disagree: The contradiction between IL-18 and IL-37 reveals shared targets in cancer
Pharmacological ResearchIL-37 is a newly discovered member of the IL-1 cytokine family which plays an important role in regulating inflammation and maintaining physiological homeostasis.
Dongjie Wang +5 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
IL-18 increases paracellular permeability when applied to the apical surface.
, 2018 HT-29 cells were grown in monolayers in Transwell chambers. When confluent, IL-18 (10 ng /ml), IL-1β (10 ng/ml) or Tat (100 ng/ml) were applied to the apical surface (A) or to the Transwell bottom wells (B).
Vikram Mehraj (376026) +7 more
core +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
, 2015 Contains fulltext : 153520.pdf (Publisher’s version ) (Open Access)Activated monocytes/macrophages and T lymphocytes that produce a cytokine storm are assumed to play a pivotal role in the pathogenesis of dengue.
Mast, Q. de +9 more
core +1 more source
Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
Anti-tumor effect of tumor specific replicating adenovirus expressing IL-12 and IL-18
, 2006 의과학과/석사[한글]암에 대한 면역 치료법은 부작용이 심각한 기존의 방사선 요법 , 항암화학 요법과는 달리 우리 몸의 면역 체계를 활성화시킴으로서 암 세포만을 특이적으로 제거하는데 그 목적이 있다. 하지만, 암 세포들은 여러 가지 전략을 사용하여 면역 체계를 교묘히 피해가며, 설사 면역 체계가 활성화 되었더라도 활성화된 항종양 면역 반응으로부터 도피할 수 있는 능력 또한 갖고 있기 때문에 항암 면역 치료에 많은 한계를 드러내고 있다. 따라서 이와 같이
최일규
core
, 2015 PURPOSE. The inflammatory process plays a major role in the pathogenesis of AMD, and recent data indicate the involvement of inflammasomes. Inflammasomes are intracellular structures that trigger inflammation by producing mature interleukin-(IL)-1b and ...
Osato Ogbeifun +8 more
core