Results 101 to 110 of about 7,505,048 (245)
, 2016 (A) IL-23p19, (B) IL-22, and (C) IL-18 mRNA levels were determined in colonic ex vivo biopsies at day (d) 8 postinfection (black circles) by Real Time PCR and expressed in Arbitrary Units (fold expression).
Ulf B. Göbel (32408) +5 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Anti-tumor effect of tumor specific replicating adenovirus expressing IL-12 and IL-18
, 2006 의과학과/석사[한글]암에 대한 면역 치료법은 부작용이 심각한 기존의 방사선 요법 , 항암화학 요법과는 달리 우리 몸의 면역 체계를 활성화시킴으로서 암 세포만을 특이적으로 제거하는데 그 목적이 있다. 하지만, 암 세포들은 여러 가지 전략을 사용하여 면역 체계를 교묘히 피해가며, 설사 면역 체계가 활성화 되었더라도 활성화된 항종양 면역 반응으로부터 도피할 수 있는 능력 또한 갖고 있기 때문에 항암 면역 치료에 많은 한계를 드러내고 있다. 따라서 이와 같이
최일규
core
Olaparib attenuates the oxLDL-mediated increase in pro-IL-1β and pro-IL-18 protein expression.
THP-1 monocytes were exposed to oxLDL, the PARP inhibitor olaparib (Olapa), or the NLRP3 inhibitor MCC950 (MCC), individually or in combination as indicated. Cell lysates were subjected to SDS-PAGE and immunoblotted with anti-pro-IL-1β (top), anti-pro-IL-
Hewang Lee (13839931) +9 more
core +1 more source
IL-18 increases paracellular permeability when applied to the apical surface.
, 2018 HT-29 cells were grown in monolayers in Transwell chambers. When confluent, IL-18 (10 ng /ml), IL-1β (10 ng/ml) or Tat (100 ng/ml) were applied to the apical surface (A) or to the Transwell bottom wells (B).
Vikram Mehraj (376026) +7 more
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
, 2011 Il capitolo presenta i risultati di un questionario rivolto agli intermediari bancari italiani che operano nel comparto del microcredito finalizzato ad indagare lo stato dell'arte di questo business (margini prodotti, modalità di valutazione del rischio,
PORRETTA, Pasqualina
core
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source