Results 101 to 110 of about 15,868,375 (334)

Targeting IL-17A attenuates neonatal sepsis mortality induced by IL-18

Proceedings of the National Academy of Sciences of the United States of America, 2016
Significance Infants born prematurely suffer the greatest incidence of and impact from sepsis among all age groups. Therapeutic interventions aimed at reducing morbidity and mortality in this vulnerable population have been unsuccessful. Interleukin (IL)-
J. L. Wynn, C. S. Wilson, J. Hawiger, Philip O. Scumpia, A. F. Marshall, Jin-hua Liu, I. Zharkikh, H. Wong, P. Lahni, J. Benjamin, E. Plosa, Jörn-Hendrik Weitkamp, E. Sherwood, L. Moldawer, R. Ungaro, H. Baker, M. C. López, Steven J. Mcelroy, Natacha Colliou, M. Mohamadzadeh, D. Moore   +20 more
semanticscholar   +1 more source

Serum levels of interleukin-17, -18, -22, and -25 in patients with bullous pemphigoid before and after treatment

Frontiers in Medicine
ObjectiveThis study aimed to explore the relationship between serum levels of interleukin-17 (IL-17), interleukin-18 (IL-18), interleukin-22 (IL-22), interleukin-25 (IL-25), anti-BP180 antibodies, anti-BP230 antibodies, and immunoglobulin E (IgE) and the
Xinyi Hong, Xinyi Hong, Xinyi Hong, Xinyi Hong, Xiuqin Wang, Xiuqin Wang, Xiuqin Wang, Xiuqin Wang, Yin Cheng, Yin Cheng, Yin Cheng, Yin Cheng, Hanqing Song, Hanqing Song, Hanqing Song, Hanqing Song, Congcong Xu, Congcong Xu, Congcong Xu, Congcong Xu, Peiguang Wang, Peiguang Wang, Peiguang Wang, Peiguang Wang   +23 more
doaj   +1 more source

Impact of BMI on IL-6 and IL-18 levels in children and adolescents with asthma [PDF]

Exploration of Medicine
Aim: To study the effect of body mass index (BMI) on interleukin (IL)-6 and IL-18 levels in children and adolescents with bronchial asthma (BA), taking into account the presence or absence of bronchial obstruction.
Regina N. Khramova, Elena V. Tush, Tatyana I. Eliseeva, Dmitriy Yu. Ovsyannikov, Svetlana V. Krasilnikova, Maxim A. Karpenko, Natalia A. Geppe, Nailya I. Kubysheva, Olga V. Khaletskaya   +8 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

IL-18 induces death in HT-29 cells.

, 2018
Light microscope images (x100) of the cells taken on day 5 after treatment with 100 ng per ml of IL-18 (A). Note that prior neutralization of the cytokine with an IL-18 neutralizing monoclonal antibody (10 ug per ml) inhibited the deleterious effects of ...
Vikram Mehraj (376026), Ossama Allam (5043434), Devendra Amre (356664), Mohammad-Ali Jenabian (49586), Jean-Pierre Routy (118465), Cecile Tremblay (5043428), Ali Ahmad (4805907), Suzanne Samarani (5043431)   +7 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis

Cell, 2015
SUMMARY The intestinal mucosal barrier controlling the resident microbiome is dependent on a protective mucus layer generated by goblet cells, impairment of which is a hallmark of the inflammatory bowel disease Ulcerative Colitis. Here we show that IL-18
Roni Nowarski, Ruaidhri Jackson, N. Gagliani, M. D. de Zoete, Noah W. Palm, Will Bailis, J. Low, Christian C. D. Harman, Morven M. Graham, E. Elinav, R. Flavell   +10 more
semanticscholar   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Plasma levels of IL-6, IL-10, IL-18, TNFα under the conditions of tobacco intoxication and after treatment with aminophthalhydrazide

Медицинская иммунология
In response to damaging factors, a cascade of cytokines is released, triggering the processes of inflammation and fibrogenesis. The purpose of our study was to evaluate the levels of cytokines (IL-6, IL-10, IL-18, TNFα) in blood plasma under conditions ...
O. V. Alpidovskaya
doaj   +1 more source

Epithelial-derived IL-18 regulates Th17 cell differentiation and Foxp3+ Treg cell function in the intestine

Mucosal Immunology, 2015
Elevated levels of interleukin-18 (IL-18) are found in many chronic inflammatory disorders, including inflammatory bowel disease (IBD), and polymorphisms in the IL18R1–IL18RAP locus are associated with IBD susceptibility. IL-18 is an IL-1 family cytokine
O. Harrison, N. Srinivasan, J. Pott, Chris Schiering, Thomas Krausgruber, N. Ilott, K. Maloy   +6 more
semanticscholar   +1 more source