Results 81 to 90 of about 7,505,048 (245)

IL-18/IL-37/IP-10 signalling complex as a potential biomarker for discriminating active and latent TB [PDF]

, 2019
BackgroundCurrently, there are serious limitations in the direct diagnosis of active tuberculosis (ATB). We evaluated the levels of the IL-18/IL-37/IP-10 signalling complex proteins in Mycobacterium tuberculosis (M.tb)-specific antigen-stimulated ...
Wlodarczyk, Marcin, Michal Seweryn (791451), Wawrocki, Sebastian, Sebastian Wawrocki (4720968), Magdalena Druszczynska (629666), Sebastian Wawrocki, Wieslawa Rudnicka (629662), Grzegorz Kielnierowski, Druszczynska, Magdalena, Michal Seweryn, Magdalena Druszczynska, Seweryn, Michał, Grzegorz Kielnierowski (629664), Kielnierowski, Grzegorz, Wieslawa Rudnicka, Marcin Wlodarczyk, Marcin Wlodarczyk (629661), Rudnicka, Wieslawa   +17 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Bursa İl Müftülüğü ve Uludağ Üniversitesi İlahiyat Fakültesi Dekanlığı Tarafından Düzenlenen Muhammed Hamidullah Sempozyumu -18-19 Kasım 2005

, 2005
Bursa İl Müftülüğü ve Uludağ Üniversitesi İlahiyat Fakültesi Dekanlığı Tarafından Düzenlenen Muhammed Hamidullah Sempozyumu -18-19 Kasım ...

core  

Plasma levels of IL-6, IL-10, IL-18, TNFα under the conditions of tobacco intoxication and after treatment with aminophthalhydrazide

Медицинская иммунология
In response to damaging factors, a cascade of cytokines is released, triggering the processes of inflammation and fibrogenesis. The purpose of our study was to evaluate the levels of cytokines (IL-6, IL-10, IL-18, TNFα) in blood plasma under conditions ...
O. V. Alpidovskaya
doaj   +1 more source

Potential of IL-1, IL-18 and Inflammasome Inhibition for the Treatment of Inflammatory Skin Diseases

Frontiers in Pharmacology, 2017
In 2002, intracellular protein complexes known as the inflammasomes were discovered and were shown to have a crucial role in the sensing of intracellular pathogen- and danger-associated molecular patterns (PAMPs and DAMPs).
Gabriele Fenini, Emmanuel Contassot, Lars E. French   +2 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Interleukin-18 and IL-18 Binding Protein

, 2013
Interleukin-18 (IL-18) is a member of the IL-1 family of cytokines. Similar to IL-1beta, IL-18 is synthesized as an inactive precursor requiring processing by caspase-1 into an active cytokine but unlike IL-1beta, the IL-18 precursor is constitutively ...
Charles A. Dinarello, Dinarello, C.A., Kaplanski, G., Novick, D., Soohyun Kim, Gilles Kaplanski, Kim, S., Daniela Novick   +7 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source