Results 91 to 100 of about 15,868,375 (334)

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Interleukin 18 (IL-18) as a target for immune intervention.

Acta Biochimica Polonica, 2016
Interleukin 18 (IL-18) is a pleiotropic cytokine involved in the regulation of innate and acquired immune response. In the milieu of IL-12 or IL-15, IL-18 is a potent inducer of IFN-gamma in natural killer (NK) cells and CD4 T helper (Th) 1 lymphocytes ...
Sebastian Wawrocki, M. Druszczyńska, M. Kowalewicz-Kulbat, W. Rudnicka   +3 more
semanticscholar   +1 more source

Role of Some Cytokines Among Infertile Women Undergoing Intracytoplasmic Sperm Injection

Medical Journal of Babylon
Background: Infertility is the incapacity to fulfill pregnancy after an appropriate time of sexual intercourse with no contraceptive measures taken. Ovulation disorders are one of the female factors that cause infertility, including polycystic ovarian ...
Dhuhaa Qasim Al-Faham, Abeer Thaher Naji Al Hasnawi, Ali Ibrahim Rahim Al-Dulaimi   +2 more
doaj   +1 more source

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

IL-1β, IL-18, and eicosanoids promote neutrophil recruitment to pore-induced intracellular traps following pyroptosis

European Journal of Immunology, 2016
Inflammasomes activate caspase‐1, initiating a lytic form of programmed cell death termed pyroptosis, which is an important innate immune defense mechanism against intracellular infections.
Ine Jorgensen, Joseph P. Lopez, Stefan Laufer, Edward A. Miao   +3 more
semanticscholar   +1 more source

Association Between Individualized Education for Kidney Replacement Therapy Modality Selection and Peritoneal Dialysis Initiation: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito, Ryuichi Yoshimura, Takaki Yamauchi, Yuta Funakoshi, Hirotaka Sonoda, Seiji Kobayashi, Hiroyuki Terawaki, Takafumi Ito   +7 more
wiley   +1 more source

Cytokine Profile in Gout: Inflammation Driven by IL-6 and IL-18?

Immunological Investigations, 2016
Introduction: Gout is considered to be an autoinflammatory disease and the presence of monosodium urate (MSU) crystals stimulates activation of NPRL3 inflammasome and subsequently caspase-1, generating production of active IL-1β and IL-18.
N. Cavalcanti, C. Marques, T. U. L. E. Lins, M. Pereira, M. J. B. de Melo Rêgo, A. Duarte, I. da Rocha Pitta, M. G. da Rocha Pitta   +7 more
semanticscholar   +1 more source

IL-1β and IL-18 secretion by PBMCs and AMs in NSCLC and SCLC relative to controls.

, 2018
Concentration of IL-1β and IL-18 levels measured in the supernatants of unstimulated cultures of PBMCs and AMs following a 2.3h period. a) IL-1β in PBMCs, b) IL-18 in PBMCs, c) IL-1β in AMs and d) IL-18 in AMs.
Irini Charalambous (5900330), Eliza Tsitoura (2575855), Katerina D. Samara (5900327), Katerina M. Antoniou (191138), Nikolaos Tzanakis (14971), Ismini Lasithiotaki (191133), Athina Trachalaki (4726929)   +6 more
core   +1 more source

The Effects of Adoptively Transferred IL-23/IL-18-Polarized Neutrophils on Tumor and Collagen-Induced Arthritis in Mice

Journal of Inflammation Research, 2021
Yifang Chen,1,* Yang Li,1,* Han Guo,1,2,* Zhaoqi Zhang,1,2 Jiayu Zhang,1,2 Xue Dong,1 Yi Liu,3 Yuan Zhuang,3 Yong Zhao1,4 1Department of State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing ...
Chen Y, Li Y, Guo H, Zhang Z, Zhang J, Dong X, Liu Y, Zhuang Y, Zhao Y   +8 more
doaj  

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source