Results 81 to 90 of about 1,536,578 (286)

Role of Some Cytokines Among Infertile Women Undergoing Intracytoplasmic Sperm Injection

Medical Journal of Babylon
Background: Infertility is the incapacity to fulfill pregnancy after an appropriate time of sexual intercourse with no contraceptive measures taken. Ovulation disorders are one of the female factors that cause infertility, including polycystic ovarian ...
Dhuhaa Qasim Al-Faham, Abeer Thaher Naji Al Hasnawi, Ali Ibrahim Rahim Al-Dulaimi   +2 more
doaj   +1 more source

Interleukin-18 produced by bone marrow- derived stromal cells supports T-cell acute leukaemia progression [PDF]

, 2014
International audienceDevelopment of novel therapies is critical for T-cell acute leukae-mia (T-ALL). Here, we investigated the effect of inhibiting the MAPK/MEK/ERK pathway on T-ALL cell growth. Unexpectedly, MEK inhibitors (MEKi) enhanced growth of 70%
André Baruchel, Bastien Gerby, Benjamin Uzan, Caroline Deswarte, Ching‐Lien Wu, Corinne Besnard‐Guérin, Diana Passaro, Florence Armstrong, Florent Dumont, Francoise Pflumio, Francoise Porteu, Frédéric Baleydier, Jacques Ghysdael, Judith Landman‐Parker, Julia Gross, Julien Calvo, Paola Ballerini, Park S, Sandrine Poglio, Thierry Leblanc, Véronique Baud, Wadman IA, Xavier Cahu   +22 more
core   +5 more sources

Predicting Chronicity in Children and Adolescents With Newly Diagnosed Immune Thrombocytopenia at the Timepoint of Diagnosis Using Machine Learning‐Based Approaches

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objectives To identify predictors of chronic ITP (cITP) and to develop a model based on several machine learning (ML) methods to estimate the individual risk of chronicity at the timepoint of diagnosis. Methods We analyzed a longitudinal cohort of 944 children enrolled in the Intercontinental Cooperative immune thrombocytopenia (ITP) Study ...
Severin Kasser, Alice Bizeul, Meera Chitlur, Hugo Donato, Jelena Roganovic, Julia E. Vogt, Thomas Kühne   +6 more
wiley   +1 more source

A Systematic Review of Evidence on the Clinical Effectiveness of Surveillance Imaging in Children With Medulloblastoma and Ependymoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Surveillance imaging aims to detect tumour relapse before symptoms develop, but it's unclear whether earlier detection of relapse leads to better outcomes in children and young people (CYP) with medulloblastoma and ependymoma. This systematic review aims to identify relevant literature to determine the efficacy of surveillance magnetic ...
Lucy Shepherd, Melissa Taylor, Helen Fulbright, Bob Phillips   +3 more
wiley   +1 more source

The Effects of Adoptively Transferred IL-23/IL-18-Polarized Neutrophils on Tumor and Collagen-Induced Arthritis in Mice

Journal of Inflammation Research, 2021
Yifang Chen,1,* Yang Li,1,* Han Guo,1,2,* Zhaoqi Zhang,1,2 Jiayu Zhang,1,2 Xue Dong,1 Yi Liu,3 Yuan Zhuang,3 Yong Zhao1,4 1Department of State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing ...
Chen Y, Li Y, Guo H, Zhang Z, Zhang J, Dong X, Liu Y, Zhuang Y, Zhao Y   +8 more
doaj  

Prognostic Impact of Treatment Modalities, Including Targeted Compartmental Radio‐Immunotherapy, in a Cohort of Neuroblastoma Patients With CNS Metastases at Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neuroblastoma (NB) with central nervous system (CNS) metastases is rare at diagnosis, but occurs more often during relapse/progression. Patients with CNS metastases face a dismal prognosis, with no standardized curative treatment available.
Vicente Santa‐Maria Lopez, Anna Felip‐Badia, Marina Caballero‐Bellon, Nazaret Sanchez‐Sierra, Alicia Castañeda, Moira Garraus, Maite Gorostegui, Margarida Simão‐Rafael, Juan Pablo Muñoz, Marta Perez‐Somarriba, Salvador Mañe, Mariana Cecilia Planells, Sara Perez‐Jaume, Jaume Mora   +13 more
wiley   +1 more source

Development of diagnostic and prognostic biomarker models for knee osteoarthritis based on NLRP3 inflammasome activation [PDF]

Journal of Medical Biochemistry
Background: This study aimed to characterize the expression profiles of the NOD-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome and its downstream effectors [Interleukin (IL)-1b, IL-18, and Gasdermin-D (GSDMD)] in degenerative knee ...
Xiong Shui, Zhou Junxin, Dong Yuying, Long Ling, Deng Gaorong   +4 more
doaj   +1 more source

The effect of swimming training and detraining on interleukin-17 and interleukin-18 of rats [PDF]

, 2017
Background and aims: Interleukin-17 (IL-17) and interleukin-18 (IL-18) are proinflammatory cytokines. The aim of the present study was to investigate the effect of swimming trainings and detraining on IL-17 and IL-18 of rats.
araiesh, Ameneh., Hassanpour, Qobad., Hosseini, Ali., Hosseini, Zahrasadat., Kheirdeh, Maryam., Noura, Mahdi.   +5 more
core  

Evaluating the levels of interleukin-1 family cytokines in sporadic amyotrophic lateral sclerosis [PDF]

, 2014
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease leading to the death of affected individuals within years. The involvement of inflammation in the pathogenesis of neurodegenerative diseases, including ALS, is ...
Barbara Borroni, Cecilia Carlesi, Diana Boraschi, Gabriele Siciliano, Ilaria Puxeddu, Paola Bossù, Paola Giungato, Paola Italiani, Paola Migliorini   +8 more
core   +1 more source

Improved Outcomes for Older Children, Adolescents, and Young Adults With Neuroblastoma in the Post‐Immunotherapy Era: An Updated Report From the International Neuroblastoma Risk Group

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background We describe clinical and biologic characteristics of neuroblastoma in older children, adolescents, and young adults (OCAYA); describe survival outcomes in the post‐immunotherapy era; and identify if there is an age cut‐off that best discriminates outcomes.
Rebecca J. Deyell, Kavitha Srivatsa, Paola Angelini, Pei‐Chi Kao, Brady Payne, Arlene Naranjo, Sveva Castelli, Miho Kato, Miki Ohira, Ulriche Pöetschger, Yaël Mossé, Lucas Moreno, Meredith S. Irwin, Ramya Ramanujachar, Wendy B. London   +14 more
wiley   +1 more source