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Interleukin-18 in lupus nephritis: a meta-analysis of cytokine signaling dysregulation in immune-mediated nephropathy. [PDF]
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A NOVEL IL-18BP ELISA SHOWS ELEVATED SERUM IL-18BP IN SEPSIS AND EXTENSIVE DECREASE OF FREE IL-18
Cytokine, 2001IL-18 binding protein (IL-18BP) is a circulating antagonist of the proinflammatory Th1 cytokine IL-18. It effectively blocks IL-18 by forming a 1:1 high affinity (Kd=400 pM) complex, exhibiting a very low dissociation rate. We have developed a sandwich ELISA for IL-18BPa and determined its limit of detection (62 pg/ml).
Giamila Fantuzzi +2 more
exaly +3 more sources
A monoclonal antibody specific for rat IL-18BP and its application in determining serum IL-18BP
Immunology Letters, 2003IL-18 binding protein (IL-18BP) is a soluble inhibitory receptor for IL-18, a proinflammatory cytokine that plays a major role in IL-12-driven Th1 cell differentiation. IL-18BP is presumed to play a vital regulatory function in IL-18-mediated immune responses, although its precise role in immunomodulation in various diseases is not well understood.
Sin-Hyeog Im, Sara Fuchs, Mir Souroujon
exaly +3 more sources
Detection of Free Bioactive IL-18 and IL-18BP in Inflammatory Disorders
2023The interleukin (IL)-18 cytokine plays an important driver role in a range of autoimmune and inflammatory diseases, as well as cancer. IL-18 is a potent inducer of interferon gamma (IFN-γ), and the bioactivity of IL-18 is regulated by its natural soluble inhibitor, IL-18-binding protein (IL-18BP), which is present at high concentrations in the ...
Sébastien, Fauteux-Daniel +4 more
openaire +2 more sources
Up-regulation of IL-18BP, but not IL-18 mRNA in rat liver by LPS
Cytokine, 2003Interleukin (IL)-18 is a pro-inflammatory cytokine that plays a critical role in inflammation leading to liver damage, through promotion of Fas-mediated apoptosis. Inhibition of IL-18 activity protects against LPS-induced lethality in mice and against liver damage induced by LPS after sensitisation of mice with Proprionibacterium acnes.
Giamal Luheshi
exaly +4 more sources
Serum IL-18 and IL-18BP Levels in Patients with Chikungunya Virus Infection
Viral Immunology, 2010Chikungunya virus infection has recently emerged in several countries. The inflammatory response is suggested to be involved in the pathology observed in this infectious disease. Interleukin-18 (IL-18) is an inducer of interferon-gamma (IFN-gamma) production and has been shown to play a role in several inflammatory diseases.
Yong Poovorawan, Chintana Chirathaworn
exaly +3 more sources
Clinical and Experimental Medicine, 2013
Interleukin-18 (IL-18) is a powerful and important cytokine in myocarditis. IL-18-binding protein (IL-18BP), a naturally occurring antagonist of IL-18, is presumed to play a vital regulatory function in IL-18-mediated immune responses. The purpose of this study was to evaluate the alterations of IL-18 and its related protein expressions and the effect ...
Gang Li, He Chang, Haruo Hanawa
exaly +3 more sources
Interleukin-18 (IL-18) is a powerful and important cytokine in myocarditis. IL-18-binding protein (IL-18BP), a naturally occurring antagonist of IL-18, is presumed to play a vital regulatory function in IL-18-mediated immune responses. The purpose of this study was to evaluate the alterations of IL-18 and its related protein expressions and the effect ...
Gang Li, He Chang, Haruo Hanawa
exaly +3 more sources
Study on the expression of IL-18, AcPL and IL-18BP mRNA in the psoriatic lesions
Current Medical Science, 2003To investigate the role of IL-18 and IL-18 binding protein (IL-18BP) in the pathogenesis of psoriasis, PT-PCR was used to semi-quantitatively analyze the mRNA expression of IL-18, AcPL (accessory protein-like) and IL-18BP in 12 psoriatic lesions and in 6 normal skin tissues. The results showed that IL-18 and AcPL mRNA were present in all specimens from
Huang Changzheng +2 more
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[The study of IL-18 and IL-18BP balance in aplastic anemia].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 2012To investigate the role of IL-18 and IL-18BP balance in aplastic anemia (AA).A total of 29 AA patients and 22 controls were recruited in present research. The expressions of IL-18 and IL-18BP were measured by enzyme-linked immunosorbent assay (ELISA). The mRNA expressions of IL-18 and IL-18BP were measured in all subjects using real-time quantitative ...
Ning-ning, Shan +6 more
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