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IL-18 signaling is regulated by caspase 6/8 and IL-18BP in turbot (Scophthalmus maximus)

International Journal of Biological Macromolecules
Interleukin (IL)-18 is synthesized as a precursor that requires intracellular processing to become functionally active. In human, IL-18 is processed by caspase 1 (CASP1). In teleost, the maturation and signal transduction mechanisms of IL-18 are unknown. We identified two IL-18 variants, IL-18a and IL-18b, in turbot.
Chao, Yu, Hang, Xu, Shuai, Jiang, Li, Sun +3 more
openaire +2 more sources

[Role of IL-18/IL-18BP balance in spleen of patients with primary immune thrombocytopenia].

Zhonghua yi xue za zhi, 2011
To investigate the role of IL-18 and IL-18BP balance in the spleens of patients with primary immune thrombocytopenia (ITP).A total of 12 active ITP patients and 10 normal controls were recruited. Their expressions of IL-18 and IL-18BP were measured by immunohistochemistry (IHC) and immunofluorescence.
Ning-ning, Shan +4 more
openaire +1 more source

[Effect of IL-18BP on Fractalkine chemokine expression in the kidney tissue of rats with renal fibrosis].

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2014
To study the expression of Fractalkine (FKN) in the kidney tissue of rats with renal fibrosis and the effect of IL-18BP on FKN.Male Wister rats were randomly assigned to sham-operation (n=24), unilatral ureteral obstruction (UUO, n=22), and IL-18 binding protein (IL-18BP) treatment groups (n=23).
Li-Min, Wang +6 more
openaire +1 more source

Functional characterization of IL-18 receptor subunits, IL-18Rα and IL-18Rβ, and its natural inhibitor, IL-18 binding protein (IL-18BP) in rainbow trout

Developmental and Comparative Immunology, 2023
Shan Nan Chen, Pin Nie, Nan Li
exaly

Anti-inflammatory and antiapoptotic effects of IL-18bp in an autologous kidney transplant model