Interleukin-18 interacts with NKCC1 to mediate brain injury after intracerebral hemorrhage. [PDF]
Xu B +7 more
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Advancing Precision Medicine in Adult-Onset Still's Disease: Insights into Biomarkers, Therapies, and COVID-19 Impacts. [PDF]
Sahoo DP.
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IL-1 family cytokines in inflammation and immunity. [PDF]
Garlanda C, Di Ceglie I, Jaillon S.
europepmc +1 more source
<i>Proteus mirabilis</i> exacerbates ulcerative colitis by inhibiting mucin production. [PDF]
Jiang Z +9 more
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Proteomic Analyses in COVID-19-Associated Secondary Hemophagocytic Lymphohistiocytosis. [PDF]
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Detection of Free Bioactive IL-18 and IL-18BP in Inflammatory Disorders
2023The interleukin (IL)-18 cytokine plays an important driver role in a range of autoimmune and inflammatory diseases, as well as cancer. IL-18 is a potent inducer of interferon gamma (IFN-γ), and the bioactivity of IL-18 is regulated by its natural soluble inhibitor, IL-18-binding protein (IL-18BP), which is present at high concentrations in the ...
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A monoclonal antibody specific for rat IL-18BP and its application in determining serum IL-18BP
Immunology Letters, 2003IL-18 binding protein (IL-18BP) is a soluble inhibitory receptor for IL-18, a proinflammatory cytokine that plays a major role in IL-12-driven Th1 cell differentiation. IL-18BP is presumed to play a vital regulatory function in IL-18-mediated immune responses, although its precise role in immunomodulation in various diseases is not well understood.
Prasanta K, Maiti +3 more
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A NOVEL IL-18BP ELISA SHOWS ELEVATED SERUM IL-18BP IN SEPSIS AND EXTENSIVE DECREASE OF FREE IL-18
Cytokine, 2001IL-18 binding protein (IL-18BP) is a circulating antagonist of the proinflammatory Th1 cytokine IL-18. It effectively blocks IL-18 by forming a 1:1 high affinity (Kd=400 pM) complex, exhibiting a very low dissociation rate. We have developed a sandwich ELISA for IL-18BPa and determined its limit of detection (62 pg/ml).
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Serum IL-18 and IL-18BP Levels in Patients with Chikungunya Virus Infection
Viral Immunology, 2010Chikungunya virus infection has recently emerged in several countries. The inflammatory response is suggested to be involved in the pathology observed in this infectious disease. Interleukin-18 (IL-18) is an inducer of interferon-gamma (IFN-gamma) production and has been shown to play a role in several inflammatory diseases.
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