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IL-1 Family Members in Bone Sarcomas [PDF]
CellsIL-1 family members have multiple pleiotropic functions affecting various tissues and cells, including the regulation of the immune response, hematopoietic homeostasis, bone remodeling, neuronal physiology, and synaptic plasticity.
Lorena Landuzzi +5 more
doaj +4 more sources
Role for IL-1 Family Cytokines in Fungal Infections [PDF]
Frontiers in Microbiology, 2021 Fungal pathogens kill approximately 1.5 million individuals per year and represent a severe disease burden worldwide. It is estimated over 150 million people have serious fungal disease such as recurrent mucosal infections or life-threatening systemic ...
James S. Griffiths +5 more
doaj +5 more sources
Autophagy and IL-1 family cytokines [PDF]
Frontiers in Immunology, 2013 Autophagy is an important intracellular homeostatic mechanism for the targeting of cytosolic constituents, including organelles, for lysosomal degradation.
James eHarris
doaj +5 more sources
Structural Basis of IL-1 Family Cytokine Signaling [PDF]
Frontiers in Immunology, 2019 Interleukin-1 (IL-1) family cytokines are key signaling molecules in both the innate and adaptive immune systems, mediating inflammation in response to a wide range of stimuli.
James K. Fields +6 more
doaj +6 more sources
IL-1 Family Antagonists in Mouse and Human Skin Inflammation [PDF]
Frontiers in Immunology, 2021 Interleukin (IL)-1 family cytokines initiate inflammatory responses, and shape innate and adaptive immunity. They play important roles in host defense, but excessive immune activation can also lead to the development of chronic inflammatory diseases ...
Praxedis Martin +9 more
doaj +6 more sources
IL-1 Family Members in Cancer; Two Sides to Every Story [PDF]
Frontiers in Immunology, 2019 The IL-1 family of cytokines currently comprises of seven ligands with pro-inflammatory activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ) as well as two ligands with anti-inflammatory activity (IL-37, IL-38).
Kevin J. Baker +6 more
doaj +6 more sources
Cause or consequence? The role of IL-1 family cytokines and receptors in neuroinflammatory and neurodegenerative diseases [PDF]
Frontiers in Immunology, 2023 Cytokines and receptors of the IL-1 family are key mediators in innate immune and inflammatory reactions in physiological defensive conditions, but are also significantly involved in immune-mediated inflammatory diseases.
Diana Boraschi +8 more
doaj +2 more sources
The Immunological Impact of IL-1 Family Cytokines on the Epidermal Barrier [PDF]
Frontiers in Immunology, 2021 The skin barrier would not function without IL-1 family members, but their physiological role in the immunological aspects of skin barrier function are often overlooked.
Tom Macleod +8 more
doaj +2 more sources
Mendelian randomization study of interleukin (IL)-1 family and lung cancer [PDF]
Scientific Reports, 2021 The role of interleukin (IL)-1 family members/receptors in lung cancer remains uncertain due to the susceptibility of observed associations to confounding.
Zhao Yang +2 more
doaj +2 more sources
IL-1 family cytokines and soluble receptors in systemic lupus erythematosus [PDF]
Arthritis Research & Therapy, 2018 Background Dysregulated production of cytokines has a critical role in systemic lupus. The aim of this work is to identify, by a comprehensive analysis of IL-1 family cytokines and receptors in serum, correlation between cytokines/receptors’ levels and ...
Paola Italiani +7 more
doaj +2 more sources