Results 111 to 120 of about 2,293,083 (280)

IL-21 signaling is essential for optimal host resistance against Mycobacterium tuberculosis infection [PDF]

, 2016
IL-21 is produced predominantly by activated CD4(+) T cells and has pleiotropic effects on immunity via the IL-21 receptor (IL-21R), a member of the common gamma chain (gamma(c)) cytokine receptor family. We show that IL-21 signaling plays a crucial role
A Bafica, A Frohlich, A Frohlich, A Kamath, A Singh, AA Chackerian, AB Kamath, AJ Zajac, AM Cooper, AM Gallegos, AO Sousa, BM Saunders, C Nunes-Alves, C Nunes-Alves, CH Ladel, CL Karp, CR Horsburgh Jr., Elizabeth J. Parks, H Elsaesser, H Kared, J Chen, J Holst, J Lim, JL Flynn, JL Flynn, JS Stumhofer, JS Woodworth, JS Yi, JS Yi, KD Mayer-Barber, KD Mayer-Barber, L Li,, LD Johnson, M Battegay, M Gonzalez-Juarrero, M Matloubian, M Parra, MD Tameris, N Pavan Kumar, NP Kumar, P Jayaraman, R Spolski, S Rahman, S Sadagopal, SM Carpenter, T Mogues, V Rigo   +46 more
core   +3 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

NRG1 functions downstream of EDS1 to regulate TIR-NLR-mediated plant immunity in Nicotiana benthamiana. [PDF]

, 2018
Effector-triggered immunity (ETI) in plants involves a large family of nucleotide-binding leucine-rich repeat (NLR) immune receptors, including Toll/IL-1 receptor-NLRs (TNLs) and coiled-coil NLRs (CNLs). Although various NLR immune receptors are known, a
Cho, Myeong-Je, Kim, Joonyoung Ryan, Pham, Julie, Qi, Tiancong, Schultink, Alex, Seo, Eunyoung, Seong, Kyungyong, Staskawicz, Brian J, Thomazella, Daniela PT   +8 more
core  

Enhanced macrophage tribbles-1 expression in murine experimental atherosclerosis. [PDF]

, 2012
Development of the atherosclerotic plaque involves a complex interplay between a number of cell types and an extensive inter-cellular communication via cell bound as well as soluble mediators.
Angyal, A., Arnold, N. D., Ernst, V., Francis, S. E., Holland, K., Kiss-Toth, E., Sung, H. Y.   +6 more
core   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Liquid Hydroxyurea (Xromi) for Children With Sickle Cell Anemia: A New Solution Compounding Existing Problems

Pediatric Blood &Cancer, EarlyView.
Alexandra Power‐Hays, Charles T. Quinn
wiley   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Alcohol Withdrawal Severity Measures for Identifying Patients Requiring High-Intensity Care

Critical Care Explorations
OBJECTIVES:. Alcohol withdrawal syndrome (AWS) may progress to require high-intensity care. Approaches to identify hospitalized patients with AWS who received higher level of care have not been previously examined. This study aimed to examine the utility
Daniel C. To, MD, Tessa L. Steel, MD, MPH, Kyle A. Carey, MPH, Cara J. Joyce, PhD, Elizabeth M. Salisbury-Afshar, MD, MPH, Dana P. Edelson, MD, Anoop Mayampurath, PhD, Matthew M. Churpek, MD, MPH, PhD, Majid Afshar, MD, MSCR   +8 more
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Erratum: IL-1 family nomenclature [PDF]

Nature Immunology, 2011
Charles Dinarello, William Arend, John Sims, Dirk Smith, Hal Blumberg, Luke O'Neill, Raphaela Goldbach-Mansky, Theresa Pizarro, H Hoffman, Philip Bufler, Marcel Nold, Pietro Ghezzi, Alberto Mantovani, Cecilia Garlanda, Diana Boraschi, Anna Rubartelli, Mihai Netea, Jos van der Meer, Leo Joosten, Tom Mandrup-Poulsen, Marc Donath, Eli Lewis, Josef Pfeilschifter, Michael Martin, Michael Kracht, H Muehl, Daniela Novick, Miodrag Lukic, Bruno Conti, Alan Solinger, Kelk Peyman, Frank van de Veerdonk, Chiristopher Gabel   +32 more
openaire   +1 more source