Results 151 to 160 of about 2,293,083 (280)

Induced Ramsey-type results and binary predicates for point sets

, 2017
Let $k$ and $p$ be positive integers and let $Q$ be a finite point set in general position in the plane. We say that $Q$ is $(k,p)$-Ramsey if there is a finite point set $P$ such that for every $k$-coloring $c$ of $\binom{P}{p}$ there is a subset $Q'$ of
Balko, Martin, Kynčl, Jan, Langerman, Stefan, Pilz, Alexander   +3 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Surgical hexing can curse outcomes

Arthroplasty Today, 2018
Brian J. McGrory, MD, MS, Jessica Taylor, FNP-C   +1 more
doaj   +1 more source

Outcome Predictions at Two Time Points among Surrogates and Physicians of Mechanically Ventilated Patients

Critical Care Explorations
OBJECTIVES:. The decisions surrogates and physicians make for incapacitated critically ill patients depend in part on their expectations for patient recovery. We sought to determine whether the accuracy of surrogate and physician outcome predictions made
Benjamin Dufour, BA, Hannah M. Duehren, MD, Ashley Eaton England, MA, Kevin Keuper, MD, Thomas V. Quinn, MD, Raj C. Shah, MD, Quyen M. Diep, MS, James Gerhart, PhD, Jared A. Greenberg, MD, MSc   +8 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Interleujin 13: a new cytokin with properties similar to those of interleukin 4 Interleuquina 13: una nueva citoquina con propiedades similares a la interleuquina 4

Iatreia, 1995
<p class="MsoNormal"><span style="font-size: 9pt; font-family: Arial">Interleukln 13 (IL-13) is a recently discovered cytokine produced by TH2 Iymphocytes. Its most important physiological activity relates with suppression of Inflammatory and
Leonardo Vargas
doaj  

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

L'interleukine-33, un nouvel acteur de la réponse anti-tumorale dans un modèle murin de cancer du côlon [PDF]

, 2014
L'interleukine-33 (IL-33) est une cytokine nucléaire de la famille des interleukines-1. L'IL-33 est exprimée par de nombreux épithéliums en contact avec l'environnement et peut être libérée sous sa forme pleine taille lors de nécrose.
Mirey, Emilie
core  

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Genetic Regulation of NKT Cell Function [PDF]

, 2017
NKT cells are specialized T cells that play important roles in the host immune response to bacteria and viruses. NKT cells produce a wide variety of cytokines and chemokines after being activated by glycolipids such as α-galactosylceramide (αGalCer ...
Malagic, Murisa
core   +1 more source