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IL-1 family cytokines in cardiovascular disease
Cytokine, 2019The interleukin (IL)-1 family is a group of cytokines crucially involved in regulating immune responses to infectious challenges and sterile insults. The family consists of the eponymous pair IL-1α and IL-1β, IL-18, IL-33, IL-37, IL-38, and several isoforms of IL-36.
Susanne Pfeiler +3 more
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The IL-1 family: regulators of immunity
Nature Reviews Immunology, 2010Over recent years it has become increasingly clear that innate immune responses can shape the adaptive immune response. Among the most potent molecules of the innate immune system are the interleukin-1 (IL-1) family members. These evolutionarily ancient cytokines are made by and act on innate immune cells to influence their survival and function.
John E, Sims, Dirk E, Smith
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Inflammasome-Independent Regulation of IL-1-Family Cytokines
Annual Review of Immunology, 2015Induction, production, and release of proinflammatory cytokines are essential steps to establish an effective host defense. Cytokines of the interleukin-1 (IL-1) family induce inflammation and regulate T lymphocyte responses while also displaying homeostatic and metabolic activities.
Netea, M.G. +4 more
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Intracellular interleukin (IL)-1 family cytokine processing enzyme
Archives of Pharmacal Research, 2016The interleukin (IL)-1 family is the largest family of interleukins. Eleven members of the IL-1 family of ligands are intracellular molecules, except a single isoform of an IL-1 receptor antagonist (IL-1Ra; also known as IL-1RN), which contains a signal peptide at the N-terminus for effective secretion.
Areum, Kwak +3 more
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2017
The family of IL-1 cytokines (IL-1F) encompasses eleven proteins that share similar structure and signaling mode (similar receptors, similar signaling pathways) (Dinarello 2013). IL-1F cytokines are involved in initiation as well as regulation of inflammation and are central players of innate immunity.
Boraschi, D.
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The family of IL-1 cytokines (IL-1F) encompasses eleven proteins that share similar structure and signaling mode (similar receptors, similar signaling pathways) (Dinarello 2013). IL-1F cytokines are involved in initiation as well as regulation of inflammation and are central players of innate immunity.
Boraschi, D.
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Negative regulatory receptors of the IL-1 family
Seminars in Immunology, 2013The IL-1 family of ligands and receptors has a central role in both innate and adaptive immune responses and is tightly controlled by antagonists, decoy receptors, scavengers, dominant negative molecules, miRNAs and other mechanisms, acting extracellularly or intracellularly.
C. Garlanda +3 more
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Structure-function relationship in the IL-1 family
Frontiers in Bioscience, 1996The interleukin 1 (IL-1) family is a group of related cytokines including two agonist proteins (IL-1alpha and IL-1beta), each derived by enzymatic cleavage of precursor proteins (pro-IL-1alpha and pro-IL-1beta), and three forms of an antagonist protein (IL-1ra, icIL-1raI, icIL-1raII).
D, Boraschi +4 more
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IL-1 family and Cutaneous Leishmaniasis: A poorly understood relationship
Cytokine & Growth Factor Reviews, 2021The cytokines of the interleukin (IL) -1 family act in the initiation of an effective immune response in Leishmania infection, represented mainly by the T helper 1 (Th1) profile, in addition to being associated with disease exacerbation and controversial contributions in the Th2 responses. The family also includes members who self-regulate inflammation,
Ester Alves da Silva, Amorim +3 more
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IL-1 family cytokines and receptors in IgG4-related disease
Cytokine, 2018The IgG4-related disease (IgG4-RD) is a fibroinflammatory condition that can affect almost any organ, often associated with eosinophilia and increased levels of IgE and IgG4. Overexpression in tissues of Th2-related cytokines but also of IFN-γ has been reported.
Capecchi Riccardo +6 more
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